Results 21 to 30 of about 357,073 (249)

Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Children with Henoch-Schönlein Purpura

Journal of International Medical Research, 2011
The balance between interleukin-18 (IL-18) and its endogenous antagonist, IL-18 binding protein (IL-18BP), was evaluated in children with Henoch-Schönlein purpura (HSP). Plasma IL-18 and IL-18BP levels and peripheral blood mononuclear cell IL-18 mRNA expression were significantly higher in patients with active HSP ( n = 30) than in healthy controls ( n
Y B, Wang, N N, Shan, O, Chen, Y, Gao, X, Zou, D E, Wei, C X, Wang, Y, Zhang   +7 more
exaly   +3 more sources

Identification of residues in an orthopoxvirus interleukin-18 binding protein involved in ligand binding and species specificity

Virology, 2004
Interleukin-18 (IL-18) is a critical cytokine in inflammation and adaptive immune responses. The IL-18 binding proteins (IL-18BP) are a family of proteins that bind to, and inhibit the activity of, IL-18. Using point mutagenesis, we analyzed the ectromelia virus IL-18BP to identify residues involved in binding.
R Mark L Buller
exaly   +3 more sources

A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers

Computational and Structural Biotechnology Journal, 2023
Interleukin 18 (IL18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. IL18 activity is tightly controlled by the constitutively secreted IL18 binding protein (IL18BP).
Yılmaz Yücehan Yazıcı, Serkan Belkaya, Emel Timucin   +2 more
doaj   +1 more source

Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2002
To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment.Serum samples were obtained before and after methotrexate treatment from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA ...
B, Bresnihan, P, Roux-Lombard, E, Murphy, D, Kane, O, FitzGerald, J-M, Dayer   +5 more
openaire   +3 more sources

IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.

PLoS ONE, 2021
Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow.
Yu Nakanishi, Yasushi Horimasu, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori   +11 more
doaj   +1 more source

Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases

Cytokine, 2022
Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and potent pro-inflammatory activities that are tightly controlled at the level of production and in the extracellular space. Indeed, IL-18 is translated as a leaderless biologically inert pro-peptide that is cleaved by caspase-1 in its N-terminus domain to become active ...
Mathilde Harel, Sébastien Fauteux-Daniel, Charlotte Girard-Guyonvarc'h, Cem Gabay   +3 more
openaire   +2 more sources

Interleukin‐18, IL‐18 binding protein and IL‐18 receptor expression in asthma: a hypothesis showing IL‐18 promotes epithelial cell differentiation

Clinical & Translational Immunology, 2021
Objective In asthma, genome‐wide association studies have shown that interleukin‐18 (IL‐18) receptor 1 gene (IL‐18R1) and sputum IL‐18 are increased during exacerbations. However, the role of the IL‐18 axis in bronchial epithelial function is unclear. To
Davinder Kaur, Latifa Chachi, Edith Gomez, Nicolas Sylvius, Christopher E Brightling   +4 more
doaj   +1 more source

Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis. [PDF]

PLoS ONE, 2010
BACKGROUND: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8+ T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation
Claudia A Nold-Petry, Thomas Lehrnbecher, Andrea Jarisch, Dirk Schwabe, Josef M Pfeilschifter, Heiko Muhl, Marcel F Nold, Marcel F Nold   +7 more
doaj   +1 more source

Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein [PDF]

Proceedings of the National Academy of Sciences, 2008
Human interleukin-18 (hIL-18) is a cytokine that plays an important role in inflammation and host defense against microbes. Its activity is regulated in vivo by a naturally occurring antagonist, the human IL-18-binding protein (IL-18BP). Functional homologs of human IL-18BP are encoded by all orthopoxviruses, including variola virus, the causative ...
Brian, Krumm, Xiangzhi, Meng, Yongchao, Li, Yan, Xiang, Junpeng, Deng   +4 more
openaire   +2 more sources

Targeting interleukin 18 with interleukin 18 binding protein [PDF]

Annals of the Rheumatic Diseases, 2000
A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of ...
openaire   +2 more sources