Results 21 to 30 of about 65,808,146 (287)

Targeting interleukin 18 with interleukin 18 binding protein [PDF]

Annals of the Rheumatic Diseases, 2000
A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of ...
openaire   +2 more sources

Interleukin-18 [PDF]

, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B., Robertson, S.E., Gracie, J.A.   +2 more
core   +1 more source

Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia

Journal of Neuroinflammation, 2012
Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria, Salani Francesca, Ciaramella Antonio, Rubino Ivo, Caltagirone Carlo, Fagioli Sabrina, Spalletta Gianfranco, Bossù Paola   +7 more
doaj   +1 more source

Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis

Pathogens, 2020
A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem.
Sebastian Wawrocki, Grzegorz Kielnierowski, Wieslawa Rudnicka, Michal Seweryn, Magdalena Druszczynska   +4 more
doaj   +1 more source

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Baeuerle, Patrick A., Kaspers, Bernd, Kirsten Schneider, Schneider, Kirsten, Baeuerle, Daniela, Daniela Baeuerle, Kirsten C. Weining, Puehler, Florian, Elvers, Sandra, Weining, Kirsten C., Florian Puehler, Sandra Elvers, Bernd Kaspers   +15 more
core   +1 more source

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells [PDF]

, 2012
Background: Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Anderson, G., Anderson George, Ojala, J.O., Sutinen, E.M., Pirttilä Tuula, Antero Salminen, Salminen Antero, Johanna O Ojala, Salminen, A., Elina M Sutinen, George Anderson, Tuula Pirttilä, Pirttilä, T., Sutinen Elina M, Ojala Johanna O   +14 more
core   +2 more sources

IL-27 regulates IL-18 binding protein in skin resident cells [PDF]

, 2012
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Wittmann, M, Miriam Wittmann, Werfel, Thomas, Bachmann, M, Doble, Rosella, Muehl, H, Thomas Werfel, Doble Rosella, Pfeilschifter, Josef (Prof. Dr.), Doble, R, Heiko Mühl, Mühl Heiko, Malte Bachmann, Wittmann Miriam, Pfeilschifter, J, Wittmann, Miriam, Bachmann Malte, Werfel, T, Josef Pfeilschifter, Werfel Thomas, Bachmann, Malte, Mühl, Heiko, Rosella Doble, Pfeilschifter Josef   +23 more
core   +2 more sources

Contribution of Mitochondrial Dysfunction Combined with NLRP3 Inflammasome Activation in Selected Neurodegenerative Diseases

Pharmaceuticals, 2021
Alzheimer’s disease and Parkinson’s disease are the most common forms of neurodegenerative illnesses. It has been widely accepted that neuroinflammation is the key pathogenic mechanism in neurodegeneration.
Anna Litwiniuk, Agnieszka Baranowska-Bik, Anita Domańska, Małgorzata Kalisz, Wojciech Bik   +4 more
doaj   +1 more source

Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]

, 2008
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat, Heiko Mühl, Malte Bachmann, Josef Pfeilschifter, Pfeilschifter, Josef, Bachmann, Malte, Mühl, Heiko, Paulukat, Jens   +7 more
core   +1 more source

Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Balkan Medical Journal, 2018
Background: Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in ...
Berk Arapi, Burcu Bayoğlu, Müjgan Cengiz, Ahmet Dirican, Serkan Burç Deser, Yerik Junusbekov, Caner Arslan   +6 more
doaj   +1 more source