Results 41 to 50 of about 357,073 (249)

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18

Frontiers in Immunology, 2017
The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP).
Robert Z. Harms, Austin J. Creer, Kristina M. Lorenzo-Arteaga, Katie R. Ostlund, Nora E. Sarvetnick, Nora E. Sarvetnick   +5 more
doaj   +1 more source

Effects of Astragalus injection and Salvia Miltiorrhiza injection on serum inflammatory markers in patients with stable coronary heart disease: a randomized controlled trial protocol

Trials, 2020
Background Coronary heart disease (CHD) is a clinical syndrome caused by coronary atherosclerosis (AS) or functional changes in coronary arteries.
Zhihao Luo, Yuntao Liu, Zhen Zhao, Xia Yan, Dawei Wang, Qing Liu   +5 more
doaj   +1 more source

IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

Journal of Translational Medicine, 2021
Background Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in ...
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim   +5 more
doaj   +1 more source

TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells

Frontiers in Cellular Neuroscience, 2020
Neuroinflammation related to microglial activation plays an important role in neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive gliosis, its ligands can reduce neuroinflammation and can be used to treat ...
Hao Feng, Yongxin Liu, Rui Zhang, Yingxia Liang, Lina Sun, Nannan Lan, Baoyu Ma   +6 more
doaj   +1 more source

IL–18 AND IMMUNITY

Медицинская иммунология, 2014
. Interleukin–18 is one of the main cytokines, inducing production of IFNg. It is the important factor of anti–infectious and anti–tumor immunity. The review represent molecular–genetic and biochemical characteristics of IL–18.
E. V. Yakushenko, J. A. Lopatnikova, S. V. Sennikov   +2 more
doaj   +1 more source

Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein

Frontiers in Pharmacology, 2022
Pharmacokinetic/pharmacodynamic (PK/PD) modeling was performed to quantitatively integrate preclinical pharmacology and toxicology data for determining the therapeutic index (TI) of an interleukin-10 (IL-10) fragment crystallizable (Fc) fusion protein ...
Zheng Yang, James Loy, Brian Poirson, Yanshan Dai, Surendran Rajendran, Shihua Xu, Vanessa Spires, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Krishna Vasudevan, Thomas Spires, Ruslan Novosiadly, Shodeinde Coker, Raymond Perez, Kelly Covello, Paul Morin, Robert Graziano, Miranda Broz, Lois Lehman-McKeeman   +23 more
doaj   +1 more source

Urinary neutrophil gelatinase-associated lipocalin: a useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients. [PDF]

PLoS ONE, 2014
Tacrolimus is widely used as an immunosuppressant in liver transplantation, and tacrolimus-induced acute kidney injury (AKI) is a serious complication of liver transplantation.
Ayami Tsuchimoto, Haruka Shinke, Miwa Uesugi, Mio Kikuchi, Emina Hashimoto, Tomoko Sato, Yasuhiro Ogura, Koichiro Hata, Yasuhiro Fujimoto, Toshimi Kaido, Junji Kishimoto, Motoko Yanagita, Kazuo Matsubara, Shinji Uemoto, Satohiro Masuda   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Targeting NLRP3 Inflammasome in Translational Treatment of Nervous System Diseases: An Update

Frontiers in Pharmacology, 2021
Neuroinflammatory response is the immune response mechanism of the innate immune system of the central nervous system. Both primary and secondary injury can activate neuroinflammatory response.
Qingying Yu, Tingting Zhao, Molin Liu, Duo Cao, Jiaxin Li, Yanling Li, Mengyao Xia, Xiaoyu Wang, Tingting Zheng, Chuanguo Liu, Xiangyu Mu, Peng Sun   +11 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source