Results 61 to 70 of about 65,808,146 (287)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Interleukin-18 and IL-18BP in inflammatory dermatological diseases
Frontiers in Immunology, 2023 Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
طب جانباز, 2014 Aims: Exposure to mustard gas leads to acute and chronic toxic effects on the skin. Results from several studies have been suggested the role of immune mediators, including Interleukin-18, in the pathogenesis of diseases associated with the urticaria ...
N. Askari +4 more
doaj
Role of Cytokines in Stressful Condition as a Trigger for a Depression
Jurnal Penyakit Dalam Indonesia, 2019 Stress disorder is one of factor which triggered depression. Stress can induced the inflammation response in human which causes depression. There is a significant role between stress and mediatory inflammasome like nucleotide-binding oligomerization ...
Febyan +3 more
doaj +1 more source
Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis
Cells, 2022 Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres +3 more
doaj +1 more source
Associations of proinflammatory cytokines with the risk of recurrent stroke [PDF]
, 2008 <p><b>Background and Purpose:</b> There are few reports on proinflammatory cytokines and risk of primary or recurrent stroke. We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-α (TNF-α) with recurrent ...
Welsh, P. +7 more
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
High-Mobility-Group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus Type 1 proviral promoter [PDF]
, 2000 HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner and with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces.
Henderson, A. +4 more
core
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity [PDF]
, 2011 The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex.
Ordureau, Alban +23 more
core +1 more source