Results 1 to 10 of about 119,018 (305)
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Nature Reviews Immunology, 2019 NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants, resulting in the formation and activation of the NLRP3 inflammasome.
Jenny Ting, Meng Deng, Karen V Swanson
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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
International Journal of Molecular Sciences, 2019 The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.
Yuan He, Nathan Kelley
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Mechanism and Regulation of NLRP3 Inflammasome Activation
Trends in Biochemical Sciences, 2016 Members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family and the pyrin and HIN-domain (PYHIN) family can form multiprotein complexes termed “inflammasomes”.
Hideki Hara, Gabriel Nunez, Yuan He
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PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
Nature, 2018 The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown.
Jueqi Chen +2 more
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
Nature, 2018 Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which underlies many chronic diseases. Although mitochondrial damage is needed for the assembly and activation of the NLRP3 inflammasome, it is unclear how macrophages are ...
Shuang Liang +2 more
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High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor [PDF]
MedCommPyroptosis is a special form of cell death that often occurs during excessive inflammation and injury, leading to tissue damage, disease progression, and other related issues. The Nod‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome is
Sen‐Lin Ji +11 more
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NLRP3 inflammasome activation and cell death
Cellular and Molecular Immunology, 2021 Rongbin Zhou, Yi Huang, Zhou Rongbin
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Molecular mechanisms regulating NLRP3 inflammasome activation
Cellular and Molecular Immunology, 2015 Jo Eun-Kyeong +2 more
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Nature Reviews Drug Discovery, 2023 Mohamed Lamkanfi
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eLife, 2022 Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induced ...
Tadayoshi Karasawa +8 more
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