Results 21 to 30 of about 119,018 (305)

Targeting the NLRP3 Inflammasome in Glaucoma [PDF]

Biomolecules, 2021
Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one or both eyes. Increased intraocular pressure (IOP) is one of the major aetiological risk factors in glaucoma, and is currently the only modifiable risk factor. However, 30–40%
Sophie Coyle, Mohammed Naeem Khan, Melody Chemaly, Breedge Callaghan, Chelsey Doyle, Colin E. Willoughby, Sarah D. Atkinson, Meredith Gregory-Ksander, Victoria McGilligan   +8 more
openaire   +3 more sources

NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features

Frontiers in Immunology, 2020
The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view has
Tabassum Rahman, Abhinit Nagar, Ellen B. Duffy, Kendi Okuda, Neal Silverman, Jonathan A. Harton   +5 more
doaj   +1 more source

NLRP3 Inflammasome and Pathobiology in AMD [PDF]

Journal of Clinical Medicine, 2015
Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of ...
Celkova, Lucia, Doyle, Sarah L., Campbell, Matthew   +2 more
openaire   +3 more sources

An update on the regulatory mechanisms of NLRP3 inflammasome activation

Cellular & Molecular Immunology, 2021
The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and triggering of pyroptosis, which is of paramount importance in a variety of physiological and ...
Seungwha Paik, J. K. Kim, Prashanta Silwal, C. Sasakawa, E. Jo   +4 more
semanticscholar   +1 more source

Sensing damage by the NLRP3 inflammasome [PDF]

Immunological Reviews, 2011
Summary:  The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase‐1, which leads to the processing and secretion of the ...
Jaklien C, Leemans, Suzanne L, Cassel, Fayyaz S, Sutterwala   +2 more
openaire   +2 more sources

FEN1-generated oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Immunity, 2022
Summary Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via cGAS-STING pathway activation and when oxidized (Ox-mtDNA), it binds cytosolic NLRP3, thereby triggering inflammasome activation. However, it is unknown how and in
Hongxu Xian, Kosuke Watari, E. Sanchez-Lopez, Joseph Offenberger, Janset Onyuru, H. Sampath, Wei Ying, H. Hoffman, G. Shadel, Michael Karin   +9 more
semanticscholar   +1 more source

Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj   +1 more source

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Cell Death and Disease, 2021
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS.
Yahui Zhang, Baohua Hou, Peiyu Liang, Xin Lu, Yifan Wu, Xinyi Zhang, Yuanteng Fan, Yumin Liu, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Song Han, Xiaohua He   +13 more
doaj   +1 more source

NLRP3 Inflammasome in Cancer and Metabolic Diseases

Nature Immunology, 2021
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in response to cellular perturbations. This assembly leads to the activation of caspase-1, which promotes maturation and release of the inflammatory cytokines interleukin-1β (
B. Sharma, T. Kanneganti
semanticscholar   +1 more source

NLRP3 inflammasome in endothelial dysfunction [PDF]

Cell Death & Disease, 2020
AbstractInflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate immune signal receptors to sense pathogens and initiate inflammatory responses under physiological and pathological conditions. The NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex.
Baochen Bai, Yanyan Yang, Qi Wang, Min Li, Chao Tian, Yan Liu, Lynn Htet Htet Aung, Pei-feng Li, Tao Yu, Xian-ming Chu   +9 more
openaire   +2 more sources