Results 41 to 50 of about 108,275 (303)
What makes gouty inflammation so variable? [PDF]
, 2017 Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core +2 more sources
Regulation of NLRP3 Inflammasome by Phosphorylation [PDF]
Frontiers in Immunology, 2018 The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Upon activation, NLRP3 triggers the assembly of inflammasome via the self-oligomerization and the recruitment of apoptosis ...
Nan Song, Nan Song, Tao Li, Tao Li
openaire +3 more sources
Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation
PLoS ONE, 2021 Background The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions.
Diane Heiser +8 more
doaj +3 more sources
A novel mechanism for NLRP3 inflammasome activation
Metabolism Open, 2022 The NLRP3 inflammasome, as an important component of the innate immune system, plays vital roles in various metabolic disorders. It has been reported that the NLRP3 inflammasome can be activated by a broad range of distinct stimuli, such as K+ efflux ...
Tan Zhang +6 more
doaj +1 more source
Deficiency of the purinergic receptor 2X7 attenuates nonalcoholic steatohepatitis induced by high-fat diet. possible role of the NLRP3 Inflammasome [PDF]
, 2017 Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the
Blasetti Fantauzzi, Claudia +6 more
core +3 more sources
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination
Frontiers in Immunology, 2019 The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the inflammatory response by promoting the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.
Zebing Rao +18 more
doaj +1 more source
Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation
Frontiers in Immunology, 2021 Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease.
Hsin-Chung Lin +13 more
doaj +1 more source
The Role of the NLRP3 Inflammasome in Fibrosis [PDF]
The Open Rheumatology Journal, 2012 Fibrosis leads to the deposition of collagens in organs and tissues. The resulting pathology induces a loss of function in the organ it is manifested in and this loss of function modulates the morbidity and mortality in that individual. Indeed, approximately 45% of all deaths in the Western world can be attributed to fibrosis and there are no FDA ...
openaire +2 more sources
Pharmacological Inhibitors of the NLRP3 Inflammasome [PDF]
Frontiers in Immunology, 2019 Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which consists of NLRP3 (nucleotide-binding domain leucine-rich repeat (NLR)
Ayesha Zahid +8 more
openaire +3 more sources
Scientific Reports, 2017 The ATPase activity of NLRP3 has pivotal role in inflammasome activation and is recognized as a good target for the development of the NLRP3 inflammasome-specific inhibitor.
Do-Wan Shim +8 more
doaj +1 more source