Results 41 to 50 of about 109,765 (163)

AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

Virulence, 2022
NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang, Zhen Luo, Jianguo Wu   +14 more
doaj   +1 more source

Nrf2 promotes NLRP3 inflammasome assembly and activation by Klf9-TXNIP axis

Cell Death Discovery
NLRP3 inflammasome activation shows a crucial role in the innate immune response that triggers inflammation. Activation is controlled by two sequential steps: a priming step, followed by an assembly step. Nrf2 has been shown to promote NLRP3 inflammasome
You Zhou, Hui You, Xin-Yu Xia, Ke Zhang, Hui Jiang, Liang-Hua Liu, Hong-Ping Liu, Ming-Cai Zhao, Su-Yu He   +8 more
doaj   +1 more source

The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

ASN Neuro, 2021
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage.
Rongrong Bai, Yue Lang, Jie Shao, Yu Deng, Reyisha Refuhati, Li Cui   +5 more
doaj   +1 more source

NLRP3 Inflammasome Promotes the Progression of Acute Myeloid Leukemia via IL-1β Pathway

Frontiers in Immunology, 2021
NLRP3 inflammasome has been reported to be associated with the pathogenesis of multiple solid tumors. However, the role of NLRP3 inflammasome in acute myeloid leukemia (AML) remains unclear.
Chaoqin Zhong, Chaoqin Zhong, Ruiqing Wang, Mingqiang Hua, Mingqiang Hua, Chen Zhang, Fengjiao Han, Miao Xu, Xinyu Yang, Guosheng Li, Xiang Hu, Tao Sun, Chunyan Ji, Daoxin Ma   +13 more
doaj   +1 more source

NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2017
Background NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CSCs) of squamous cell carcinoma of ...
Cong-Fa Huang, Lei Chen, Yi-Cun Li, Lei Wu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun   +6 more
doaj   +1 more source

Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy

Biomedical Journal, 2023
Background: The role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in the pathogenesis of hepatic encephalopathy (HE) is unclear. Mitochondrial reactive oxygen species (mtROS) is a signal for NLRP3 inflammasome
So Yeong Cheon, Min-Yu Kim, Jeongmin Kim, Eun Jung Kim, Eun Hee Kam, Inja Cho, Bon-Nyeo Koo, So Yeon Kim   +7 more
doaj   +1 more source

NLRP3, un inflammasome sous contrôle

, 2018
International audienceThe innate immunity constitutes an efficient barrier by rapidly detecting pathogens and tissue damages through pattern recognition receptors including NLRP3.
Bénédicte F. Py, Py, Bénédicte, Groslambert, Marine, Marine Groslambert   +3 more
core   +1 more source

Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice

Diabetes & Vascular Disease Research, 2020
Background: NLR family pyrin domain containing 3 (NLRP3) inflammasome has been implicated in the development of atherosclerosis and several studies have suggested that inhibiting NLRP3 inflammasome could be a potential therapeutic approach to treat ...
Jingfei Zhao, Zhengtang Wang, Zhilu Yuan, Shuzhen Lv, Qingbo Su   +4 more
doaj   +1 more source

THE ROLE OF INFLAMMASOME AND CASPASE-1 IN REGULATING ADAPTIVE RESPONSE TO OXIDATIVE STRESS IN MOUSE HEPATOCYTES [PDF]

, 2013
In myeloid cells, oxidative stress can induce the activation of caspase-1 through canonical inflammasome signaling, which leads to the release of proinflammatory cytokines IL-1β/IL-18 and a potentially damaging inflammatory response.
Sun, Qian
core  

NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation

, 2021
In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state ...
Mahbuba Akther, Kwang-Ho Lee, Md Ezazul Haque, Tae-Bong Kang, Jooho Park   +4 more
core   +1 more source