Results 41 to 50 of about 119,018 (305)

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome During Apoptosis

Immunity, 2012
SUMMARY We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β).
K. Shimada, T. Crother, J. Karlin, J. Dagvadorj, N. Chiba, Shuang Chen, V. K. Ramanujan, Andrea J. Wolf, L. Vergnes, D. Ojcius, A. Rentsendorj, M. Vargas, Candace R. Guerrero, Yinsheng Wang, K. Fitzgerald, D. Underhill, T. Town, M. Arditi   +17 more
semanticscholar   +1 more source

Cardiolipin and the Nlrp3 Inflammasome [PDF]

Cell Metabolism, 2013
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting ...
openaire   +3 more sources

Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Aberrant activation of the NLRP3 (nucleotide‐binding oligomerization domain, leucine‐rich repeat–containing receptor family pyrin domain‐containing 3) inflammasome is thought to play a causative role in atherosclerosis.
Suwen Chen, Yadong Wang, Yamu Pan, Yao Liu, Shuang Zheng, Ke Ding, Kaiyu Mu, Ye Yuan, Zhaoyang Li, Hongxian Song, Ying Jin, Jian Fu   +11 more
doaj   +1 more source

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
doaj   +1 more source

Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice

Molecules, 2023
The Nod-like receptor family PYRIN domain containing 3 (NLRP3) inflammasome is a multiprotein signaling complex that plays a pivotal role in innate immunity, and the dysregulated NLRP3 inflammasome activation is implicated in various diseases. Tiliroside
Chao Zhong, Jing Yang, Keke Deng, Xiaoya Lang, Jiangtao Zhang, Min Li, Liang Qiu, Guoyue Zhong, Jun Yu   +8 more
doaj   +1 more source

A novel mechanism for NLRP3 inflammasome activation

Metabolism Open, 2022
The NLRP3 inflammasome, as an important component of the innate immune system, plays vital roles in various metabolic disorders. It has been reported that the NLRP3 inflammasome can be activated by a broad range of distinct stimuli, such as K+ efflux ...
Tan Zhang, Jingyao Zhao, Tiemin Liu, Wei Cheng, Yibing Wang, Shuzhe Ding, Ru Wang   +6 more
doaj   +1 more source

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

Frontiers in Aging Neuroscience, 2022
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing ...
Hallie Blevins, Yiming Xu, Savannah Biby, Shijun Zhang   +3 more
semanticscholar   +1 more source

Cell Swelling and the NLRP3 Inflammasome [PDF]

Immunity, 2013
Multiple chemically and biologically diverse stimuli activate the NLRP3 inflammasome, but the precise mechanism for activation remains to be determined (Davis et al., 2011xDavis, B.K., Wen, H., and Ting, J.P.-Y. Annu. Rev. Immunol. 2011; 29: 707–735Crossref | PubMed | Scopus (433)See all ReferencesDavis et al., 2011).
Boyle, Joseph P., Bryant, Clare E., Monie, Tom P.   +2 more
openaire   +2 more sources

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

Acta Pharmaceutica Sinica B, 2019
Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic ...
Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao, Zhaofang Bai   +11 more
doaj   +1 more source

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease.
Hsin-Chung Lin, Hsin-Chung Lin, Yu-Jen Chen, Yu-Jen Chen, Yu-Jen Chen, Yau-Huei Wei, Hsin-An Lin, Chien-Chou Chen, Tze-Fan Liu, Yi-Lin Hsieh, Kuo-Yang Huang, Kuan-Hung Lin, Hsueh-Hsiao Wang, Lih-Chyang Chen   +13 more
doaj   +1 more source