Results 51 to 60 of about 109,765 (163)

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science
The aberrant activation of the NOD‐like receptor protein 3 (NLRP3) inflammasome has been implicated in the pathogenesis of various human inflammatory diseases.
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
doaj   +1 more source

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2020
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu, Zi-mo Chen, Xiaoyan Wu, Linjie Zhang, Ying Cao, Pingzheng Zhou   +5 more
doaj   +1 more source

Spotlight on the NLRP3 inflammasome pathway

, 2018
Marine Groslambert,1–5 Bénédicte F Py1–5 1Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Lyon, France; 2INSERM, U1111, Lyon, France; 3Ecole Normale Supérieure de Lyon, Lyon, France ...
Py BF, Groslambert M
core   +2 more sources

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

EMBO Molecular Medicine, 2018
The dysregulation of NLRP3 inflammasome can cause uncontrolled inflammation and drive the development of a wide variety of human diseases, but the medications targeting NLRP3 inflammasome are not available in clinic. Here, we show that tranilast (TR), an
Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang, Rongbin Zhou   +10 more
doaj   +1 more source

RORy regulates the NLRP3 inflammasome [PDF]

, 2019
RAR-related orphan receptor (ROR) is a nuclear receptor that plays an essential role in the development of T helper 17 (Th17) cells of the adaptive immune system.
Murray, Meghan H., Avdagic, Amer, Billon, Cyrielle, Burris, Thomas P.   +3 more
core   +1 more source

Methylglyoxal-modification of NLRP3 interrupts NLRP3-NEK7 interaction diminishing inflammasome activation and neuroinflammation

Journal of Neuroinflammation
Background The NLRP3 inflammasome is a supramolecular complex that mediates pyroptosis and the production of inflammatory cytokines. Aberrant activation of the NLRP3 inflammasome has been implicated in the pathogenesis of various diseases, including ...
Xin Shi, Jing Dong, Ying Yang, Yi-Lin He, Heng Li, Tong Du, Bing Yang, Chun-Lin Yang, Peng Zhang, Tao Xin   +9 more
doaj   +1 more source

Etude des différents signaux d'activation de l'inflammasome dans les monocytes/macrophages : implication dans la réponse inflammatoire vis-à-vis des nanotubes de carbone et de Leishmania infantum [PDF]

, 2012
La vision de l'immunité en tant qu'entité discriminant les éléments du soi à protéger et du non soi à combattre a évolué ces dernières années avec la découverte des signaux de dangers endogènes et certains de leurs récepteurs associés.
Meunier, Etienne
core  

Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS

, 2022
Leptin and ROS are implicated in the regulation of inflammatory pathways including NLRP3-inflammasome. We investigated the functional link between leptin, ROS and NLRP3-inflammasome formation/activation in osteoarthritis (OA), an age-related disease.
Mourmoura E., Papathanasiou I., Trachana V., Konteles V., Tsoumpou A., Goutas A., Papageorgiou A.-A., Stefanou N., Tsezou A.
core   +1 more source

UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation

Advanced Science
NLRP3 (NOD, LRR and pyrin domain‐containing protein 3) inflammasome is important for host defense against infections and maintaining homeostasis. Aberrant activation of NLRP3 inflammasome is closely related to various inflammatory diseases.
Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen   +14 more
doaj   +1 more source

Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

eLife, 2020
NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis ...
Jakob Malsy, Andrea C Alvarado, Joseph O Lamontagne, Karin Strittmatter, Alexander G Marneros   +4 more
doaj   +1 more source