Results 51 to 60 of about 108,275 (303)
Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC
Frontiers in Oncology, 2019 Background: NLRP3 inflammasome is an inflammatory mediator. The expression of NLRP3 inflammasome is associated with the development of various tumors and is closely related to the prognosis of tumors.
Yi Xue +11 more
doaj +1 more source
IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]
, 2016 Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias +9 more
core +1 more source
NLRP3 inflammasome pathways in atherosclerosis [PDF]
Atherosclerosis, 2017 Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (
Baldrighi, Marta, Mallat, Ziad, Li, Xuan
openaire +3 more sources
Acta Pharmaceutica Sinica B, 2019 Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic ...
Zhilei Wang +11 more
doaj +1 more source
Autophagy in Microglia and Alzheimer's disease [PDF]
, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core +1 more source
Clinical and Translational Medicine, 2020 Inflammation is an important process involved in several cardiovascular diseases (CVDs), and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital player in innate immunity and inflammation.
Yucheng Wang +6 more
doaj +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
DDX3X: stressing the NLRP3 inflammasome [PDF]
Cell Research, 2019 Stress granules and inflammasomes are intracellular complexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro-survival stress granules or pro-death NLRP3 ...
Daniel Fox, Si Ming Man
openaire +3 more sources
Ecotoxicology and Environmental Safety, 2021 Arsenic exposure is related to insulin resistance (IR). However, the underlying mechanism is still uncertain. NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome is a key driving factor of IR.
Jingyuan Zhang +12 more
doaj +1 more source
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source