Results 51 to 60 of about 119,018 (305)

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Nature Communications, 2021
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism
Pan Pan, Miaomiao Shen, Zhen-Dong Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pinjun Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li, Jianguo Wu   +21 more
semanticscholar   +1 more source

Cellular localization of NLRP3 inflammasome [PDF]

Protein & Cell, 2013
AbstractInflammasome is a large protein complex activated upon cellular stress or microbial infection, which triggers maturation of pro-inflammatory cytokines interleukin-1β and interleukin-18 through caspase-1 activation. Nod-like receptor family protein 3 (NLRP3) is the most characterized inflammasome activated by various stimuli.
Yan, Wang, Chen, Yang, Kairui, Mao, Shuzhen, Chen, Guangxun, Meng, Bing, Sun   +5 more
openaire   +2 more sources

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination

Scientific Reports, 2017
The ATPase activity of NLRP3 has pivotal role in inflammasome activation and is recognized as a good target for the development of the NLRP3 inflammasome-specific inhibitor.
Do-Wan Shim, Woo-Young Shin, Sang-Hyeun Yu, Byung-Hak Kim, Sang-Kyu Ye, Sushruta Koppula, Hyung-Sik Won, Tae-Bong Kang, Kwang-Ho Lee   +8 more
doaj   +1 more source

Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination

Frontiers in Immunology, 2019
The NLRP3 inflammasome is a multiprotein oligomer responsible for activation of the inflammatory response by promoting the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.
Zebing Rao, Zebing Rao, Xin Chen, Xin Chen, Junxian Wu, Junxian Wu, Mengjun Xiao, Mengjun Xiao, Jing Zhang, Binghao Wang, Lei Fang, Hongjie Zhang, Xiaoming Wang, Xiaoming Wang, Shuo Yang, Shuo Yang, Yunzi Chen, Yunzi Chen, Yunzi Chen   +18 more
doaj   +1 more source

Regulation of NLRP3 Inflammasome by Phosphorylation [PDF]

Frontiers in Immunology, 2018
The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Upon activation, NLRP3 triggers the assembly of inflammasome via the self-oligomerization and the recruitment of apoptosis ...
Nan Song, Nan Song, Tao Li, Tao Li
openaire   +3 more sources

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

PLoS ONE, 2021
Background The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions.
Diane Heiser, Joëlle Rubert, Adeline Unterreiner, Claudine Maurer, Marion Kamke, Ursula Bodendorf, Christopher J. Farady, Ben Roediger, Frédéric Bornancin   +8 more
doaj   +3 more sources

Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC

Frontiers in Oncology, 2019
Background: NLRP3 inflammasome is an inflammatory mediator. The expression of NLRP3 inflammasome is associated with the development of various tumors and is closely related to the prognosis of tumors.
Yi Xue, Huai-Dong Du, Di Tang, Duo Zhang, Jian Zhou, Chang-Wen Zhai, Cun-Cun Yuan, Chi-Yao Hsueh, Sheng-Jie Li, Yu Heng, Lei Tao, Li-Ming Lu   +11 more
doaj   +1 more source

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

Cell Death and Disease, 2019
The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18.
Yang Yang, Huanan Wang, M. Kouadir, Houhui Song, F. Shi   +4 more
semanticscholar   +1 more source

Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction

Pharmacological Reviews, 2023
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and effector functions to regulate inflammation in health and disease.
Qiang Ma
semanticscholar   +1 more source

The Role of the NLRP3 Inflammasome in Fibrosis [PDF]

The Open Rheumatology Journal, 2012
Fibrosis leads to the deposition of collagens in organs and tissues. The resulting pathology induces a loss of function in the organ it is manifested in and this loss of function modulates the morbidity and mortality in that individual. Indeed, approximately 45% of all deaths in the Western world can be attributed to fibrosis and there are no FDA ...
openaire   +2 more sources