Results 71 to 80 of about 119,018 (305)

Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders

Frontiers in Immunology, 2022
The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential role in the innate immune system by identifying and eliminating a plethora of endogenous and exogenous threats to the host.
Bora Tastan, Bora Tastan, Burak I. Arioz, Burak I. Arioz, Sermin Genc, Sermin Genc   +5 more
doaj   +1 more source

The NLRP3 inflammasome: contributions to inflammation-related diseases

Cellular & Molecular Biology Letters, 2023
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18.
Ying Chen, Xingyan Ye, G. Escames, Wangrui Lei, Xin Zhang, Meng Li, Tong Jing, Yulin Yao, Zhenye Qiu, Zheng Wang, D. Acuña-Castroviejo, Yang Yang   +11 more
semanticscholar   +1 more source

DDX3X: stressing the NLRP3 inflammasome [PDF]

Cell Research, 2019
Stress granules and inflammasomes are intracellular complexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro-survival stress granules or pro-death NLRP3 ...
Daniel Fox, Si Ming Man
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Nature Immunology, 2022
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including ...
L. Billingham, J. Stoolman, K. Vasan, Arianne E. Rodriguez, T. Poor, M. Szibor, H. Jacobs, Colleen R. Reczek, Aida Rashidi, P. Zhang, Jason M. Miska, N. Chandel   +11 more
semanticscholar   +1 more source

Vitamin D and the NLRP3 Inflammasome [PDF]

Applied Sciences, 2020
Vitamin D (VD) is a steroid hormone classically known for its key role in maintaining calcium homeostasis in the body. VD also has important immunomodulatory functions. This review explores evidence for a role of VD in attenuating the activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome.
Tunbridge, Matthew, Franca Gois, Pedro Henrique   +1 more
openaire   +4 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy

Biomedical Journal, 2023
Background: The role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in the pathogenesis of hepatic encephalopathy (HE) is unclear. Mitochondrial reactive oxygen species (mtROS) is a signal for NLRP3 inflammasome
So Yeong Cheon, Min-Yu Kim, Jeongmin Kim, Eun Jung Kim, Eun Hee Kam, Inja Cho, Bon-Nyeo Koo, So Yeon Kim   +7 more
doaj   +1 more source

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

International Journal of Molecular Medicine, 2023
The inflammasome regulates innate immunity by serving as a signaling platform. The Nod-like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis-associated speck-like protein (ASC) and pro-caspase-1, is by far the ...
Xiaolu Zhang, Ziyu Wang, Yujiao Zheng, Qun Yu, M. Zeng, Liding Bai, Lin-Po Yang, Maojuan Guo, Xijuan Jiang, Jiali Gan   +9 more
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source