Results 71 to 80 of about 109,765 (163)

DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions

, 2020
Resumen del trabajo presentado en el American Transplant Congress 2020, originalmente programado para tener lugar en Filadelfia (Estados Unidos), se convirtió en un Congreso Virtual debido a COVID-19, celebrado del 30 de mayo al 3 de junio de 2020Purpose:
Folch-Puy, Emma, Panisello-Roselló, Arnau, Carbonell, Teresa, Bardallo, Raquel G., Teixeira da Silva, Rui, Roselló-Catafau, Joan   +5 more
core   +1 more source

Regulation of NLRP3 Inflammasome by Phosphorylation [PDF]

, 2018
The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Tao Li, Nan Song
core   +1 more source

Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype

, 2022
Jesús Beltrán-García,1– 3 Rebeca Osca-Verdegal,1,3 Daniel Pérez-Cremades,2,3 Susana Novella,2,3 Carlos Hermenegildo,2,3 Federico V Pallardó,1– 3 José Luis García-Giménez1– 3 1Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER ...
Hermenegildo C, Pallardó FV, Osca-Verdegal R, Beltrán-García J, Pérez-Cremades D, Novella S, García-Giménez JL   +6 more
core  

Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC

, 2023
Background Abnormal activation of NLRP3 inflammasome is related to a series of inflammatory diseases, including type 2 diabetes, gouty arthritis, non-alcoholic steatohepatitis (NASH), and neurodegenerative disorders.
Wei Shi, Guang Xu, Tingting Liu, Jia Zhao, Ziying Wei, Zhixian Hong, Hongbin Liu, Jincai Wen, Xiaorong Hou, Jun Zhao, Yongping Yang, Wei Luo, Wenjun Zou, Wenqing Mu, Lutong Ren, Xiaohe Xiao, Zhaofang Bai, Zhie Fang, Xiaoyan Zhan   +18 more
core   +1 more source

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

, 2015
Ema Ozaki,1 Matthew Campbell,1 Sarah L Doyle2,3 1Department of Genetics, 2Department of Clinical Medicine, School of Medicine, Trinity College Dublin, 3National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin ...
Campbell M, Doyle SL, Ozaki E
core  

TREM-1 inhibition or ondansetron administration ameliorates NLRP3 inflammasome and pyroptosis in traumatic brain injury-induced acute lung injury

Introduction Recently, NLR family pyrin domain containing 3 (NLRP3) and pyroptosis have been reported to be involved in traumatic brain injury-induced acute lung injury (TBI-ALI).
Yiqin Yu, Zhenhua Zeng, Shenhai Gong, Rui Dong, Na Qin, Fen Li, Xiaojie Li, Lin Huang, Hong Yang   +8 more
core   +1 more source

Reviewing the importance of TLR-NLRP3-pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitors

, 2021
Cells encounter continuous challenges due to tissue insult caused by endogenous and/or exogenous stimuli. Among the mechanisms set in place to counterbalance the tissue insult, innate immunity is always at the forefront.
Nampoothiri, M, Kinra, M, Mudgal, J, Arora, D, Kinra, Manas, Mudgal, Jayesh, Nampoothiri, Madhavan, Arora, Devinder   +7 more
core   +1 more source

Nimbolide ameliorates ARDS and ulcerative colitis by disrupting NLRP3 inflammasome activation

Communications Biology
Excessive activation of the NLRP3 inflammasome drives the pathogenesis of diverse inflammatory diseases. However, the clinical application of NLRP3 inflammasome inhibitors remains a significant challenge.
Haowen Xu, Yao Lin, Weiwei Luo, Shiying Sheng, Yongan Xu, Zhaocai Zhang   +5 more
doaj   +1 more source

Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in Macrophages

Frontiers in Pharmacology, 2019
Background: The NLRP3 inflammasome is one of the key contributors to impaired wound healing in diabetes. In this study, we assessed the role of rapamycin on high glucose-induced inflammation in THP-1-derived macrophages and investigated the underlying ...
Jiezhi Dai, Chaoyin Jiang, Hua Chen, Yimin Chai   +3 more
doaj   +1 more source

Vitamin D and the NLRP3 Inflammasome

, 2020
Vitamin D (VD) is a steroid hormone classically known for its key role in maintaining calcium homeostasis in the body. VD also has important immunomodulatory functions.
Pedro Henrique França Gois, Matthew Tunbridge   +1 more
core   +1 more source