Results 91 to 100 of about 119,018 (305)

NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2017
Background NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CSCs) of squamous cell carcinoma of ...
Cong-Fa Huang, Lei Chen, Yi-Cun Li, Lei Wu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun   +6 more
doaj   +1 more source

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2020
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu, Zi-mo Chen, Xiaoyan Wu, Linjie Zhang, Ying Cao, Pingzheng Zhou   +5 more
doaj   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science
The aberrant activation of the NOD‐like receptor protein 3 (NLRP3) inflammasome has been implicated in the pathogenesis of various human inflammatory diseases.
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
doaj   +1 more source

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy

Frontiers in Immunology, 2023
In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is the main cause of vision impairment. Chronic low-grade inflammation plays an essential role in DR development.
Xiaoqin Zheng, Jia Wan, Gang Tan
semanticscholar   +1 more source

Role of the NLRP3 inflammasome in cancer [PDF]

Molecular Cancer, 2018
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory ...
Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin, Amirhossein Sahebkar   +4 more
openaire   +3 more sources

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Methylglyoxal-modification of NLRP3 interrupts NLRP3-NEK7 interaction diminishing inflammasome activation and neuroinflammation

Journal of Neuroinflammation
Background The NLRP3 inflammasome is a supramolecular complex that mediates pyroptosis and the production of inflammatory cytokines. Aberrant activation of the NLRP3 inflammasome has been implicated in the pathogenesis of various diseases, including ...
Xin Shi, Jing Dong, Ying Yang, Yi-Lin He, Heng Li, Tong Du, Bing Yang, Chun-Lin Yang, Peng Zhang, Tao Xin   +9 more
doaj   +1 more source

Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease

Nature Medicine, 2015
The ketone bodies β-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during states of energy deficit by serving as alternative sources of ATP. BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or
Y. Youm, K. Nguyen, R. Grant, Emily L. Goldberg, M. Bodogai, Dongin Kim, D. D'Agostino, N. Planavsky, Christopher R. Lupfer, T. Kanneganti, Seokwon Kang, T. Horvath, T. Fahmy, P. Crawford, A. Biragyn, E. Alnemri, V. Dixit   +16 more
semanticscholar   +1 more source

TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury

International Journal on Biological Sciences, 2023
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1-triggered inflammation response remains poorly understood.
W. Zhong, Tian Liu, Hui-Hui Yang, J. Duan, Jin-Tong Yang, Xin‐Xin Guan, Jian-Bing Xiong, Yan-Feng Zhang, Chen-Yu Zhang, Yong Zhou, C. Guan   +10 more
semanticscholar   +1 more source