Results 91 to 100 of about 102,344 (304)

UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation

Advanced Science
NLRP3 (NOD, LRR and pyrin domain‐containing protein 3) inflammasome is important for host defense against infections and maintaining homeostasis. Aberrant activation of NLRP3 inflammasome is closely related to various inflammatory diseases.
Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen   +14 more
doaj   +1 more source

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

, 2013
International audienceNLRP3 is an important pattern recognition receptor involved in mediating inflammasome activation in response to viral and bacterial infections as well as various proinflammatory stimuli associated with tissue damage or malfunction ...
Py, Bénédicte F., Vakifahmetoglu-Norberg, Helin, Yuan, Junying, Kim, Mi-Sung   +3 more
core   +1 more source

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome

, 2021
NLRP3 is an important pattern recognition receptor in the innate immune system, and its activation induces a large number of pro-inflammatory cytokines, IL-1β and IL-18 which are involved in the development of various diseases.
Shuzhe Ding, Ru Wang, Tan Zhang
core   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

The Development of Inhibitors for NLRP3 Inflammasome

ACS Medicinal Chemistry Letters
This patent highlights the preparation, pharmaceutical compositions, and therapeutic applications of NLRP3 inflammasome inhibitors. NLRP3 [NOD (Nucleotide-binding Oligomerization Domain)-like receptor family pyrin domain containing 3] is a versatile protein that plays a significant role in the immune system, particularly in mediating responses to ...
Xin Zhou, Steven H. Liang
openaire   +3 more sources

DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions

, 2020
Resumen del trabajo presentado en el American Transplant Congress 2020, originalmente programado para tener lugar en Filadelfia (Estados Unidos), se convirtió en un Congreso Virtual debido a COVID-19, celebrado del 30 de mayo al 3 de junio de 2020Purpose:
Folch-Puy, Emma, Panisello-Roselló, Arnau, Carbonell, Teresa, Bardallo, Raquel G., Teixeira da Silva, Rui, Roselló-Catafau, Joan   +5 more
core   +1 more source

NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation

, 2021
In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state ...
Mahbuba Akther, Kwang-Ho Lee, Md Ezazul Haque, Tae-Bong Kang, Jooho Park   +4 more
core   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

eLife, 2020
NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis ...
Jakob Malsy, Andrea C Alvarado, Joseph O Lamontagne, Karin Strittmatter, Alexander G Marneros   +4 more
doaj   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source