Results 111 to 120 of about 102,344 (304)
Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke
Frontiers in Cellular Neuroscience, 2020 Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng +6 more
doaj +1 more source
, 2022 Jesús Beltrán-García,1– 3 Rebeca Osca-Verdegal,1,3 Daniel Pérez-Cremades,2,3 Susana Novella,2,3 Carlos Hermenegildo,2,3 Federico V Pallardó,1– 3 José Luis García-Giménez1– 3 1Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER ...
Hermenegildo C +6 more
core
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation [PDF]
, 2012 Cell volume regulation is a primitive response to alterations in environmental osmolarity. The NLRP3 inflammasome is a multiprotein complex that senses pathogen- and danger-associated signals.
Martínez, Carlos M. +13 more
core +1 more source
Advanced Science, EarlyView.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
The NLRP3 inflammasome in ischemic stroke
Frontiers in StrokeIschemic stroke is a more common type of stroke and a leading cause of physical disability, cognitive decline, and death worldwide. Events occurring after an ischemic stroke episode determine the severity and outcomes. The NLR family pyrin domain containing 3 (NLRP3) inflammasome has emerged as a major contributor to the pathogenesis of ischemic stroke.
Sepiso K. Masenga +5 more
openaire +3 more sources
The Role of the NLRP3 Inflammasome in Fibrosis [PDF]
The Open Rheumatology Journal, 2012 Fibrosis leads to the deposition of collagens in organs and tissues. The resulting pathology induces a loss of function in the organ it is manifested in and this loss of function modulates the morbidity and mortality in that individual. Indeed, approximately 45% of all deaths in the Western world can be attributed to fibrosis and there are no FDA ...
openaire +2 more sources
Defective mitochondrial fission augments NLRP3 inflammasome activation [PDF]
, 2015 Despite the fact that deregulated NLRP3 inflammasome activation contributes to the pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by which NLRP3 inflammasome signaling is initiated or potentiated remains poorly ...
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core +1 more source
Development of NLRP3 Inflammasome Inhibitors
, 2022 Neuroinflammation has proven to play an essential role in the pathogenesis of neurodegenerative diseases by encouraging the maturation and secretion of pro-inflammatory mediators.
Blevins, Hallie M
core +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source