Results 121 to 130 of about 108,275 (303)

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation

Cell Reports
Summary: Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 inflammasome activation.
Stuart Leishman, Najd M. Aljadeed, Liyunhe Qian, Shamshad Cockcroft, Jacques Behmoaras, Paras K. Anand   +5 more
doaj   +1 more source

The Development of Inhibitors for NLRP3 Inflammasome

ACS Medicinal Chemistry Letters
This patent highlights the preparation, pharmaceutical compositions, and therapeutic applications of NLRP3 inflammasome inhibitors. NLRP3 [NOD (Nucleotide-binding Oligomerization Domain)-like receptor family pyrin domain containing 3] is a versatile protein that plays a significant role in the immune system, particularly in mediating responses to ...
Xin Zhou, Steven H. Liang
openaire   +3 more sources

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

The role of the NLRP3 inflammasome in gout

Journal of Inflammation Research, 2011
Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Recent studies suggest that orchestration of the MSU-induced inflammatory response is dependent on the proinflammatory cytokine IL-1β, underlined by promising results in early IL-1 ...
Kingsbury, SR, Conaghan, P, McDermott, M
openaire   +6 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke

Frontiers in Cellular Neuroscience, 2020
Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng, Zi-Xuan Tan, Man-Man Wang, Ying Xing, Fang Dong, Feng Zhang, Feng Zhang   +6 more
doaj   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Spotlight on the NLRP3 inflammasome pathway

Journal of Inflammation Research, 2018
Inflammation is triggered by a repertoire of receptors detecting infections and damages. Some of these receptors directly bind microbial ligands, while others recognize endogenous molecules exposed under stress conditions, including infections. Most of these receptors can be engaged by a relatively limited number of stimuli.
Groslambert, Marine, Py, Bénédicte
openaire   +6 more sources