Results 121 to 130 of about 102,344 (304)
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders
NLRP3 plays a role in the development of autoinflammatory diseases. NLRP3, ASC, and Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate immune system.
Chen, C, Hu, H, Wang, S
core +1 more source
Keys to NLRP3 inflammasome activation and the resulting pyroptosis from an evolutionary perspective
, 2020 The body has evolved maladaptive biochemical mechanisms to mitigate a predicted infection when it is under psychological stress. It also triggers depression or withdrawal behavior accompanied by biochemical inflammatory cascades.
Hijaz, Marwa
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Advanced Science, EarlyView.Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan +13 more
wiley +1 more source
Magnesium-enriched deep-sea water inhibits NLRP3 inflammasome activation and dampens inflammation
HeliyonThe NLRP3 inflammasome is an essential component of the innate immune system, but excessive activation can lead to inflammatory diseases. Ion fluxes across the plasma membrane or from intracellular stores are known to regulate NLRP3 inflammasome ...
Hsueh-Hsiao Wang +11 more
doaj +1 more source
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
, 2015 Ema Ozaki,1 Matthew Campbell,1 Sarah L Doyle2,3 1Department of Genetics, 2Department of Clinical Medicine, School of Medicine, Trinity College Dublin, 3National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin ...
Campbell M, Doyle SL, Ozaki E
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Advanced Science, EarlyView.High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao +11 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Background: The NLRP3 inflammasome is one of the key contributors to impaired wound healing in diabetes. In this study, we assessed the role of rapamycin on high glucose-induced inflammation in THP-1-derived macrophages and investigated the underlying ...
Jiezhi Dai +3 more
doaj +1 more source
Advanced Science, EarlyView.PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang +5 more
wiley +1 more source
NLRP3 inflammasome: A therapeutic option for kidney disease? [PDF]
, 2017 Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others ...
Suárez Useche, Raibel Janis +2 more
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