Results 81 to 90 of about 119,018 (305)

Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice

Diabetes & Vascular Disease Research, 2020
Background: NLR family pyrin domain containing 3 (NLRP3) inflammasome has been implicated in the development of atherosclerosis and several studies have suggested that inhibiting NLRP3 inflammasome could be a potential therapeutic approach to treat ...
Jingfei Zhao, Zhengtang Wang, Zhilu Yuan, Shuzhen Lv, Qingbo Su   +4 more
doaj   +1 more source

The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

Frontiers in Immunology, 2023
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Xiaoyan Zhan, Qiang Li, Guang Xu, Xiaohe Xiao, Zhaofang Bai   +4 more
semanticscholar   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

EMBO Molecular Medicine, 2018
The dysregulation of NLRP3 inflammasome can cause uncontrolled inflammation and drive the development of a wide variety of human diseases, but the medications targeting NLRP3 inflammasome are not available in clinic. Here, we show that tranilast (TR), an
Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang, Rongbin Zhou   +10 more
doaj   +1 more source

NLRP3 inflammasome in neuroinflammation and central nervous system diseases

Cellular & Molecular Immunology
Neuroinflammation plays an important role in the pathogenesis of various central nervous system (CNS) diseases. The NLRP3 inflammasome is an important intracellular multiprotein complex composed of the innate immune receptor NLRP3, the adaptor protein ...
Wenjing Xu, Yi Huang, Rongbin Zhou
semanticscholar   +1 more source

Structural mechanism for NEK7-licensed NLRP3 inflammasome activation

Nature, 2019
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly and activation of the NLRP3 inflammasome in interphase. Here we report a
H. Sharif, Li Wang, W. L. Wang, V. Magupalli, Liudmila Andreeva, Q. Qiao, Arthur V. Hauenstein, Zhaolong Wu, G. Núñez, Youdong Mao, Hao Wu   +10 more
semanticscholar   +1 more source

Hexokinase dissociation from mitochondria promotes oligomerization of VDAC which facilitates NLRP3 inflammasome assembly and activation

Science immunology, 2023
NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection, sterile inflammation, and disease, including colitis, diabetes ...
Sung Hoon Baik, V. K. Ramanujan, Courtney A. Becker, Sarah N. Fett, D. Underhill, Andrea J. Wolf   +5 more
semanticscholar   +1 more source

The NLRP3 inflammasome in ischemic stroke

Frontiers in Stroke
Ischemic stroke is a more common type of stroke and a leading cause of physical disability, cognitive decline, and death worldwide. Events occurring after an ischemic stroke episode determine the severity and outcomes. The NLR family pyrin domain containing 3 (NLRP3) inflammasome has emerged as a major contributor to the pathogenesis of ischemic stroke.
Sepiso K. Masenga, Sepiso K. Masenga, Annet Kirabo, Annet Kirabo, Annet Kirabo, Annet Kirabo   +5 more
openaire   +3 more sources

Role of NLRP3 Inflammasomes in Atherosclerosis

Journal of Atherosclerosis and Thrombosis, 2017
Inflammation with macrophage infiltration is a key feature of atherosclerosis. Although the mechanisms had been unclear, emerging evidence unveiled that NLRP3 inflammasomes, which regulate caspase-1 activation and subsequent processing of pro-IL-1β, trigger vascular wall inflammatory responses and lead to progression of atherosclerosis.
Karasawa, Tadayoshi, Takahashi, Masafumi
openaire   +3 more sources

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source