Results 61 to 70 of about 109,765 (163)
Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
, 2013 International audienceNLRP3 is an important pattern recognition receptor involved in mediating inflammasome activation in response to viral and bacterial infections as well as various proinflammatory stimuli associated with tissue damage or malfunction ...
Py, Bénédicte F. +3 more
core +1 more source
Defective mitochondrial fission augments NLRP3 inflammasome activation [PDF]
, 2015 Despite the fact that deregulated NLRP3 inflammasome activation contributes to the pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by which NLRP3 inflammasome signaling is initiated or potentiated remains poorly ...
유제욱
core +1 more source
Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome
BMC Biology, 2020 Background Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets.
Wenbiao Wang +18 more
doaj +1 more source
, 2022 De-Gang Mo,1 Lin Wang,2 Qian-Feng Han,1 Kang Yu,3 Jia-Hui Liu,1 Heng-Chen Yao1 1Department of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of China; 2Cardiologic Color Doppler Room,
Mo DG +5 more
core
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation [PDF]
, 2012 Cell volume regulation is a primitive response to alterations in environmental osmolarity. The NLRP3 inflammasome is a multiprotein complex that senses pathogen- and danger-associated signals.
Martínez, Carlos M. +13 more
core +1 more source
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis [PDF]
, 2020 The discovery of inflammasomes has enriched our knowledge in the pathogenesis of multiple inflammatory diseases. The NLR pyrin domain-containing protein 3 (NLRP3) has emerged as the most versatile and well-characterized inflammasome, consisting of an ...
Ana Ferrero-Andrés +7 more
core +1 more source
Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor
, 2016 Autoimmune and inflammatory diseases are associated with inappropriate activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, but suitable inhibitors against such improper activations remain scarce.
Wen Liu (39804) +4 more
core +1 more source
Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders
NLRP3 plays a role in the development of autoinflammatory diseases. NLRP3, ASC, and Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate immune system.
Chen, C, Hu, H, Wang, S
core +1 more source
Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation
Cell ReportsSummary: Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 inflammasome activation.
Stuart Leishman +5 more
doaj +1 more source
Therapy targeted to the NLRP3 inflammasome in chronic kidney disease [PDF]
Background: The NLRP3 inflammasome is a cytoplasmic polymeric protein complex composed of the cytoplasmic sensor NLRP3, the apoptosis-related spot-like protein ASC, and the inflammatory protease caspase-1.
Yong Ji +4 more
core +1 more source