Results 61 to 70 of about 119,018 (305)

Pharmacological Inhibitors of the NLRP3 Inflammasome [PDF]

Frontiers in Immunology, 2019
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which consists of NLRP3 (nucleotide-binding domain leucine-rich repeat (NLR)
Ayesha Zahid, Ayesha Zahid, Bofeng Li, Bofeng Li, Arnaud John Kombe Kombe, Tengchuan Jin, Tengchuan Jin, Tengchuan Jin, Jinhui Tao   +8 more
openaire   +3 more sources

NLRP3 Inflammasome Promotes the Progression of Acute Myeloid Leukemia via IL-1β Pathway

Frontiers in Immunology, 2021
NLRP3 inflammasome has been reported to be associated with the pathogenesis of multiple solid tumors. However, the role of NLRP3 inflammasome in acute myeloid leukemia (AML) remains unclear.
Chaoqin Zhong, Chaoqin Zhong, Ruiqing Wang, Mingqiang Hua, Mingqiang Hua, Chen Zhang, Fengjiao Han, Miao Xu, Xinyu Yang, Guosheng Li, Xiang Hu, Tao Sun, Chunyan Ji, Daoxin Ma   +13 more
doaj   +1 more source

NLRP3 inflammasome activation drives tau pathology

Nature, 2019
Alzheimer’s disease is characterized by the accumulation of amyloid-beta in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, together resulting in neurodegeneration and cognitive decline1.
Christina Ising, C. Venegas, Shuangshuang Zhang, H. Scheiblich, S. Schmidt, A. Vieira-Saecker, S. Schwartz, Shadi Albasset, R. McManus, Darío Tejera, A. Griep, Francesco Santarelli, F. Brosseron, S. Opitz, James Stunden, Maximilian Merten, R. Kayed, D. Golenbock, D. Blum, E. Latz, L. Buée, M. Heneka   +21 more
semanticscholar   +1 more source

NLRP3 inflammasome pathways in atherosclerosis [PDF]

Atherosclerosis, 2017
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (
Baldrighi, Marta, Mallat, Ziad, Li, Xuan
openaire   +2 more sources

NLRP3 inflammasome, an immune‐inflammatory target in pathogenesis and treatment of cardiovascular diseases

Clinical and Translational Medicine, 2020
Inflammation is an important process involved in several cardiovascular diseases (CVDs), and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital player in innate immunity and inflammation.
Yucheng Wang, Xiaoxiao Liu, Hui Shi, Yong Yu, Ying Yu, Minghui Li, Ruizhen Chen   +6 more
doaj   +1 more source

NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance

Ecotoxicology and Environmental Safety, 2021
Arsenic exposure is related to insulin resistance (IR). However, the underlying mechanism is still uncertain. NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome is a key driving factor of IR.
Jingyuan Zhang, Tianming Qiu, Liping Jiang, Ningning Wang, Yuhan Zhu, Rushan Yan, Shengyu Wang, Jie Bai, Xiaoxia Shi, Guang Yang, Xiaofang Liu, Xiaofeng Yao, Xiance Sun   +12 more
doaj   +1 more source

AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

Virulence, 2022
NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang, Zhen Luo, Jianguo Wu   +14 more
doaj   +1 more source

K+ efflux is the Common Trigger of NLRP3 inflammasome Activation by Bacterial Toxins and Particulate Matter

Immunity, 2013
Summary The NLRP3 inflammasome is an important component of the innate immune system. However, its mechanism of activation remains largely unknown. We show that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP and particulate ...
Raúl Muñoz-Planillo, Peter Kuffa, Giovanny J. Martínez-Colón, B. L. Smith, Thekkelnaycke M. Rajendiran, G. Núñez   +5 more
semanticscholar   +1 more source

NLRP3 Inflammasome and MS/EAE [PDF]

Autoimmune Diseases, 2013
Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules.
Makoto Inoue, Mari L. Shinohara
openaire   +2 more sources

The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

ASN Neuro, 2021
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage.
Rongrong Bai, Yue Lang, Jie Shao, Yu Deng, Reyisha Refuhati, Li Cui   +5 more
doaj   +1 more source