Results 31 to 40 of about 102,344 (304)

Mechanism of NLRP3 inflammasome activation [PDF]

Annals of the New York Academy of Sciences, 2014
Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating the innate immune system, initiating pyroptosis (an ...
Fayyaz S, Sutterwala, Stefanie, Haasken, Suzanne L, Cassel   +2 more
openaire   +2 more sources

The double sides of NLRP3 inflammasome activation in sepsis

, 2023
International audienceAbstract Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic.
Py, Bénédicte F., Vigneron, Clara, Venet, Fabienne, Monneret, Guillaume   +3 more
core   +1 more source

Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj   +1 more source

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Cell Communication and Signaling, 2023
Background Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying ...
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao   +12 more
doaj   +1 more source

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]

, 2012
Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe, Meunier, Etienne, Bernard Pipy, David Olagnier, José Bernad, Agnès Coste, Authier, Hélène, Emmanuel Flahaut, Béraud, Maryse, Bernad, José, Flahaut, Emmanuel, Etienne Meunier, Maryse Béraud, Pipy, Bernard, Lise Lefèvre, Christophe Dardenne, Coste, Agnès, Hélène Authier, Olagnier, David, Lefèvre, Lise   +19 more
core   +1 more source

Knocking In the NLRP3 Inflammasome [PDF]

Immunity, 2009
Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.
openaire   +2 more sources

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
core   +2 more sources

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress [PDF]

, 2023
NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and ...
Mélanie Bodnar-Wachtel, Annabelle Ballesta, Janet Hall, Hall, Janet, Guey, Baptiste, Sylvie Lantuejoul, François Ghiringhelli, Truntzer, Caroline, Couté, Yohann, Elise Ballot, Huber, Anne-Laure, Lantuejoul, Sylvie, Baptiste Guey, Lecuelle, Julie, Sabine Hacot, Ghiringhelli, François, Anne-Laure Huber, Bodnar-Wachtel, Mélanie, Agnès Tissier, Delphine Burlet, Caroline Truntzer, Bénédicte F Py, Gérossier, Laetitia, Goutagny, Nadège, Laetitia Gérossier, Birke Bartosch, Bartosch, Birke, Julie Lecuelle, Burlet, Delphine, Virginie Petrilli, Ballot, Elise, Yohann Couté, Hacot, Sabine, Gorry, Julie, Nadège Goutagny, Py, Bénédicte F, Ballesta, Annabelle, Tissier, Agnès, Py, Bénédicte, F, Petrilli, Virginie, Julie Gorry   +40 more
core   +1 more source

Role of the NLRP3 Inflammasome in Preeclampsia [PDF]

Frontiers in Endocrinology, 2020
Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE).
Koumei Shirasuna, Tadayoshi Karasawa, Masafumi Takahashi   +2 more
openaire   +3 more sources

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Schnurr, M., Bauer, Christian, Düwell, Peter, Endres, S., Bauer, C., Duewell, P., Schnurr, Max, Lehr, Hans-Anton, Lehr, H.A., Endres, Stefan   +9 more
core   +1 more source