Results 31 to 40 of about 108,275 (303)

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

NLRP3 Inflammasome—A Key Player in Antiviral Responses

Frontiers in Immunology, 2020
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and caspase-1.
Chunyuan Zhao, Chunyuan Zhao, Chunyuan Zhao, Wei Zhao, Wei Zhao   +4 more
doaj   +1 more source

Tivantinib alleviates inflammatory diseases by directly targeting NLRP3

iScience, 2023
Summary: NLRP3 inflammasome-mediated immune responses are involved in the pathogenesis of multiple inflammatory diseases, but few clinical drugs are identified that directly target the NLRP3 inflammasome to treat these diseases to date.
Yi Huang, Yun Guo, Yan Zhou, Qian Huang, Yi Ru, Yingli Luo, Wen Xu   +6 more
doaj   +1 more source

Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Aberrant activation of the NLRP3 (nucleotide‐binding oligomerization domain, leucine‐rich repeat–containing receptor family pyrin domain‐containing 3) inflammasome is thought to play a causative role in atherosclerosis.
Suwen Chen, Yadong Wang, Yamu Pan, Yao Liu, Shuang Zheng, Ke Ding, Kaiyu Mu, Ye Yuan, Zhaoyang Li, Hongxian Song, Ying Jin, Jian Fu   +11 more
doaj   +1 more source

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
doaj   +1 more source

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]

, 2014
Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed, Liu, Zhiping, Lupfer, Christopher R, Stokes, Kate L, Vogel, Peter   +6 more
core   +3 more sources

Cell Swelling and the NLRP3 Inflammasome [PDF]

Immunity, 2013
Multiple chemically and biologically diverse stimuli activate the NLRP3 inflammasome, but the precise mechanism for activation remains to be determined (Davis et al., 2011xDavis, B.K., Wen, H., and Ting, J.P.-Y. Annu. Rev. Immunol. 2011; 29: 707–735Crossref | PubMed | Scopus (433)See all ReferencesDavis et al., 2011).
Boyle, Joseph P., Bryant, Clare E., Monie, Tom P.   +2 more
openaire   +2 more sources

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

Cellular localization of NLRP3 inflammasome [PDF]

Protein & Cell, 2013
AbstractInflammasome is a large protein complex activated upon cellular stress or microbial infection, which triggers maturation of pro-inflammatory cytokines interleukin-1β and interleukin-18 through caspase-1 activation. Nod-like receptor family protein 3 (NLRP3) is the most characterized inflammasome activated by various stimuli.
Yan, Wang, Chen, Yang, Kairui, Mao, Shuzhen, Chen, Guangxun, Meng, Bing, Sun   +5 more
openaire   +2 more sources

Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice

Molecules, 2023
The Nod-like receptor family PYRIN domain containing 3 (NLRP3) inflammasome is a multiprotein signaling complex that plays a pivotal role in innate immunity, and the dysregulated NLRP3 inflammasome activation is implicated in various diseases. Tiliroside
Chao Zhong, Jing Yang, Keke Deng, Xiaoya Lang, Jiangtao Zhang, Min Li, Liang Qiu, Guoyue Zhong, Jun Yu   +8 more
doaj   +1 more source