Results 11 to 20 of about 109,765 (163)

NLRP3 Inflammasome—A Key Player in Antiviral Responses

Frontiers in Immunology, 2020
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and caspase-1.
Chunyuan Zhao, Chunyuan Zhao, Chunyuan Zhao, Wei Zhao, Wei Zhao   +4 more
doaj   +2 more sources

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination

Scientific Reports, 2017
The ATPase activity of NLRP3 has pivotal role in inflammasome activation and is recognized as a good target for the development of the NLRP3 inflammasome-specific inhibitor.
Do-Wan Shim, Woo-Young Shin, Sang-Hyeun Yu, Byung-Hak Kim, Sang-Kyu Ye, Sushruta Koppula, Hyung-Sik Won, Tae-Bong Kang, Kwang-Ho Lee   +8 more
doaj   +2 more sources

The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney

Cells, 2019
Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) forms an inflammasome with apoptosis-associated speck-like protein containing a CARD (ASC) and pro-caspase-1, which is followed by the cleavage of pro-caspase-1 to ...
Yang Gyun Kim, Su-Mi Kim, Ki-Pyo Kim, Sang-Ho Lee, Ju-Young Moon   +4 more
doaj   +2 more sources

Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

Neural Regeneration Research
Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is ...
Qiuqin Han, Wenhui Li, Peiqing Chen, Lijuan Wang, Xiwen Bao, Renyan Huang, Guobin Liu, Xiaorong Chen   +7 more
doaj   +2 more sources

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress [PDF]

, 2023
NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and ...
Mélanie Bodnar-Wachtel, Annabelle Ballesta, Janet Hall, Hall, Janet, Guey, Baptiste, Sylvie Lantuejoul, François Ghiringhelli, Truntzer, Caroline, Couté, Yohann, Elise Ballot, Huber, Anne-Laure, Lantuejoul, Sylvie, Baptiste Guey, Lecuelle, Julie, Sabine Hacot, Ghiringhelli, François, Anne-Laure Huber, Bodnar-Wachtel, Mélanie, Agnès Tissier, Delphine Burlet, Caroline Truntzer, Bénédicte F Py, Gérossier, Laetitia, Goutagny, Nadège, Laetitia Gérossier, Birke Bartosch, Bartosch, Birke, Julie Lecuelle, Burlet, Delphine, Virginie Petrilli, Ballot, Elise, Yohann Couté, Hacot, Sabine, Gorry, Julie, Nadège Goutagny, Py, Bénédicte F, Ballesta, Annabelle, Tissier, Agnès, Py, Bénédicte, F, Petrilli, Virginie, Julie Gorry   +40 more
core   +1 more source

The double sides of NLRP3 inflammasome activation in sepsis

, 2023
International audienceAbstract Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic.
Py, Bénédicte F., Vigneron, Clara, Venet, Fabienne, Monneret, Guillaume, Clara Vigneron, Bénédicte F. Py, Fabienne Venet, Guillaume Monneret   +7 more
core   +1 more source

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
core   +2 more sources

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]

, 2012
Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe, Meunier, Etienne, Bernard Pipy, David Olagnier, José Bernad, Agnès Coste, Authier, Hélène, Emmanuel Flahaut, Béraud, Maryse, Bernad, José, Flahaut, Emmanuel, Etienne Meunier, Maryse Béraud, Pipy, Bernard, Lise Lefèvre, Christophe Dardenne, Coste, Agnès, Hélène Authier, Olagnier, David, Lefèvre, Lise   +19 more
core   +1 more source

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

, 2021
International audienceAbstract NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC ...
Visvikis, Orane, Ricci, Roméo, Py, Bénédicte, Rey, Amaury, Lagrange, Brice, Niu, Tingting, Wong, Jeimin, Groslambert, Marine, Walker, Olivier, Wang, Ping, Chautard, Séverine, Henry, Thomas, Zhang, Zhirong, de Rosny, Charlotte, Patoli, Danish, Hologne, Maggy, Cosson, Camille, Hacot, Sabine, Petrilli, Virginie, Boyer, Laurent, Py, Bénedicte F., De Rosny, C. (Charlotte), Chautard, S. (Séverine), Patoli, D. (Danish), Séverine Chautard, Niu, T. (Tingting), Sabine Hacot, Ricci, R. (Romeo), Cosson, C. (Camille), Boyer, L. (Laurent), Ping Wang, Visvikis, O. (Oriane), Bénédicte F. Py, Hacot, S. (Sabine), Amaury Rey, Jeimin Wong, Charlotte De Rosny, Marine Groslambert, Groslambert, M. (Marine), Henry, T. (Thomas), Camille Cosson, Petrilli, V. (Virginie), Tingting Niu, Laurent Boyer, Rey, A. (Amaury), Danish Patoli, Walker, O. (Olivier), Thomas Henry, Zhang, Z. (Zhirong), Brice Lagrange, Roméo Ricci, Olivier Walker, Wang, P. (Ping), Orane Visvikis, Maggy Hologne, Virginie Petrilli, Zhirong Zhang, Wong, J. (Jeimin), Hologne, M. (Maggy)   +58 more
core   +1 more source

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Schnurr, M., Bauer, Christian, Düwell, Peter, Endres, S., Bauer, C., Duewell, P., Schnurr, Max, Lehr, Hans-Anton, Lehr, H.A., Endres, Stefan   +9 more
core   +1 more source