Results 11 to 20 of about 119,018 (305)
The NLRP3 inflammasome: activation and regulation
Trends in Biochemical Sciences, 2022 The NLRP3 inflammasome is a cytoplasmic supramolecular complex that is activated in response to cellular perturbations triggered by infection and sterile injury.
Jie Xu, Gabriel Núñez
semanticscholar +3 more sources
Inhibiting the NLRP3 Inflammasome [PDF]
Molecules, 2020 Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy +2 more
openaire +4 more sources
Neurodegenerative Disease and the NLRP3 Inflammasome [PDF]
Frontiers in Pharmacology, 2021 The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue. These diseases are characterised by a progressive neuronal loss in the brain or peripheral nervous system, and generally involve protein aggregation, as well as metabolic abnormalities ...
Jonathan A. Holbrook +14 more
openaire +6 more sources
C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome
Frontiers in Pharmacology, 2021 Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu +7 more
doaj +1 more source
Role of the NLRP3 Inflammasome in Preeclampsia [PDF]
Frontiers in Endocrinology, 2020 Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE).
Koumei Shirasuna +2 more
openaire +3 more sources
Cytochrome c Negatively Regulates NLRP3 Inflammasomes. [PDF]
PLoS ONE, 2016 The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome ...
Chong-Shan Shi, John H Kehrl
doaj +1 more source
Frontiers in Pharmacology, 2021 The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei +27 more
doaj +1 more source
NLRP3 Inflammasome and Inflammatory Diseases [PDF]
Oxidative Medicine and Cellular Longevity, 2020 Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation.
Zheng Wang +8 more
openaire +2 more sources
Frontiers in Immunology, 2021 The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels.
Tiantian Tang +6 more
doaj +1 more source
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation
Annual Review of Immunology, 2022 As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1.
Jianing Fu, Hao Wu
semanticscholar +1 more source