Results 11 to 20 of about 102,344 (304)
Inhibiting the NLRP3 Inflammasome [PDF]
Molecules, 2020 Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18.
El-Sharkawy, Lina +5 more
core +6 more sources
Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases [PDF]
Advanced ScienceThe aberrant activation of the NOD‐like receptor protein 3 (NLRP3) inflammasome has been implicated in the pathogenesis of various human inflammatory diseases.
Xinyu Xia +7 more
doaj +2 more sources
Spotlight on the NLRP3 inflammasome pathway
Journal of Inflammation Research, 2018 Marine Groslambert,1–5 Bénédicte F Py1–5 1Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Lyon, France; 2INSERM, U1111, Lyon, France; 3Ecole Normale Supérieure de Lyon, Lyon, France ...
Py BF, Groslambert M
core +8 more sources
The role of the NLRP3 inflammasome in gout [PDF]
Journal of Inflammation Research, 2011 Sarah R Kingsbury1,2, Philip G Conaghan1,2, Michael F McDermott1,21Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine 2NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds,
Conaghan, P +5 more
core +7 more sources
NLRP3 Inflammasome in Cardioprotective Signaling [PDF]
Journal of Cardiovascular Pharmacology, 2019 The NLRP3 inflammasome may contribute to infarct development during acute cardiac ischemia-reperfusion (IR). Because infarct size strongly correlates with the degree of heart failure in the long term, therapies that reduce reperfusion injury are still ...
Coert J. Zuurbier, Zuurbier, Coert J.
core +4 more sources
Regulation of NLRP3 Inflammasome by Phosphorylation [PDF]
Frontiers in Immunology, 2018 The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Tao Li, Nan Song
core +5 more sources
RORy regulates the NLRP3 inflammasome [PDF]
Journal of Biological Chemistry, 2019 RAR-related orphan receptor (ROR) is a nuclear receptor that plays an essential role in the development of T helper 17 (Th17) cells of the adaptive immune system.
Murray, Meghan H. +3 more
core +5 more sources
The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney
Cells, 2019 Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) forms an inflammasome with apoptosis-associated speck-like protein containing a CARD (ASC) and pro-caspase-1, which is followed by the cleavage of pro-caspase-1 to ...
Sang-Ho Lee, Yang Gyun, Ju-Young Moon
exaly +3 more sources
Targeting the NLRP3 Inflammasome in Glaucoma [PDF]
Biomolecules, 2021 Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one or both eyes. Increased intraocular pressure (IOP) is one of the major aetiological risk factors in glaucoma, and is currently the only modifiable risk factor. However, 30–40%
Sophie Coyle +8 more
openaire +3 more sources
eLife, 2022 Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation induced ...
Tadayoshi Karasawa +8 more
doaj +1 more source