Results 11 to 20 of about 108,275 (303)

Inhibiting the NLRP3 Inflammasome [PDF]

Molecules, 2020
Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy, David Brough, Sally Freeman   +2 more
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Neurodegenerative Disease and the NLRP3 Inflammasome [PDF]

Frontiers in Pharmacology, 2021
The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue. These diseases are characterised by a progressive neuronal loss in the brain or peripheral nervous system, and generally involve protein aggregation, as well as metabolic abnormalities ...
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Emily Caseley, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott   +14 more
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Role of the NLRP3 Inflammasome in Preeclampsia [PDF]

Frontiers in Endocrinology, 2020
Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE).
Koumei Shirasuna, Tadayoshi Karasawa, Masafumi Takahashi   +2 more
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NLRP3 Inflammasome and Inflammatory Diseases [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation.
Zheng Wang, Simei Zhang, Ying Xiao, Wunai Zhang, Shuai Wu, Tao Qin, Yangyang Yue, Weikun Qian, Li Li   +8 more
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Targeting the NLRP3 Inflammasome in Glaucoma [PDF]

Biomolecules, 2021
Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one or both eyes. Increased intraocular pressure (IOP) is one of the major aetiological risk factors in glaucoma, and is currently the only modifiable risk factor. However, 30–40%
Sophie Coyle, Mohammed Naeem Khan, Melody Chemaly, Breedge Callaghan, Chelsey Doyle, Colin E. Willoughby, Sarah D. Atkinson, Meredith Gregory-Ksander, Victoria McGilligan   +8 more
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NLRP3 Inflammasome and Pathobiology in AMD [PDF]

Journal of Clinical Medicine, 2015
Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of ...
Celkova, Lucia, Doyle, Sarah L., Campbell, Matthew   +2 more
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Sensing damage by the NLRP3 inflammasome [PDF]

Immunological Reviews, 2011
Summary:  The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase‐1, which leads to the processing and secretion of the ...
Jaklien C, Leemans, Suzanne L, Cassel, Fayyaz S, Sutterwala   +2 more
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NLRP3 inflammasome in endothelial dysfunction [PDF]

Cell Death & Disease, 2020
AbstractInflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate immune signal receptors to sense pathogens and initiate inflammatory responses under physiological and pathological conditions. The NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex.
Baochen Bai, Yanyan Yang, Qi Wang, Min Li, Chao Tian, Yan Liu, Lynn Htet Htet Aung, Pei-feng Li, Tao Yu, Xian-ming Chu   +9 more
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Effects of phosphorylation on the NLRP3 inflammasome [PDF]

Archives of Biochemistry and Biophysics, 2019
The pyrin domain containing Nod-like receptors (NLRPs) are a family of pattern recognition receptors known to regulate an array of immune signaling pathways. Emergent studies demonstrate the potential for regulatory control of inflammasome assembly by phosphorylation, notably NLRP3. Over a dozen phosphorylation sites have been identified for NLRP3 with
Christina F, Sandall, Justin A, MacDonald   +1 more
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Mechanism of NLRP3 inflammasome activation [PDF]

Annals of the New York Academy of Sciences, 2014
Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating the innate immune system, initiating pyroptosis (an ...
Fayyaz S, Sutterwala, Stefanie, Haasken, Suzanne L, Cassel   +2 more
openaire   +2 more sources