Results 51 to 60 of about 357,073 (249)

Identification of small molecule inhibitors of Interleukin-18

Scientific Reports, 2017
Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive immune defense but its aberrant activities are also associated with inflammatory diseases such ...
Brian Krumm, Xiangzhi Meng, Yan Xiang, Junpeng Deng   +3 more
doaj   +1 more source

Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Frontiers in Immunology, 2023
Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity.
Xiaoyun Wang, Xiaoyun Wang, Lian Wang, Xiang Wen, Lu Zhang, Xian Jiang, Xian Jiang, Gu He, Gu He   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

Cells, 2022
Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Involvement of neutrophils and interleukin-18 in nociception in a mouse model of muscle pain

Molecular Pain, 2018
Muscle pain is a common condition that relates to various pathologies. Muscle overuse induces muscle pain, and neutrophils are key players in pain production. Neutrophils also play a central role in chronic pain by secreting interleukin (IL)-18.
Shinichirou Yoshida, Yoshihiro Hagiwara, Masahiro Tsuchiya, Masamichi Shinoda, Masashi Koide, Hiroyasu Hatakeyama, Chayanit Chaweewannakorn, Toshihisa Yano, Yasuhito Sogi, Nobuyuki Itaya, Takuya Sekiguchi, Yutaka Yabe, Keiichi Sasaki, Makoto Kanzaki, Eiji Itoi   +14 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Role of Cytokines in Stressful Condition as a Trigger for a Depression

Jurnal Penyakit Dalam Indonesia, 2019
Stress disorder is one of factor which triggered depression. Stress can induced the inflammation response in human which causes depression. There is a significant role between stress and mediatory inflammasome like nucleotide-binding oligomerization ...
Febyan , Sri Handawati Wijaya, Ayudhea Tannika, Johannes Hudyono   +3 more
doaj   +1 more source

Identification and characterization of genome-wide resistance gene analogs (RGAs) of durian (Durio zibethinus L.)

Journal of Genetic Engineering and Biotechnology, 2022
Background Durian (Durio zibethinus L.) is a tropical fruit crop which is popular in Southeast Asia but recently gaining popularity in other parts of the world. In this study, we analyzed the resistance gene analogs (RGAs) of durian through mining of the
Cris Q. Cortaga, Romnick A. Latina, Rosteo R. Habunal, Darlon V. Lantican   +3 more
doaj   +1 more source

IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii

Cell Reports, 2023
Summary: Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous work has shown a limited role for endogenous IL-18 in control of this parasite ...
Joseph T. Clark, Orr-El Weizman, Daniel L. Aldridge, Lindsey A. Shallberg, Julia Eberhard, Zachary Lanzar, Devon Wasche, John D. Huck, Ting Zhou, Aaron M. Ring, Christopher A. Hunter   +10 more
doaj   +1 more source