Results 31 to 40 of about 357,073 (249)

Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia

Journal of Neuroinflammation, 2012
Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria, Salani Francesca, Ciaramella Antonio, Rubino Ivo, Caltagirone Carlo, Fagioli Sabrina, Spalletta Gianfranco, Bossù Paola   +7 more
doaj   +1 more source

Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis

Pathogens, 2020
A thorough understanding of the processes modulating the innate and acquired immune response to Mycobacterium tuberculosis (M.tb) infection in the context of gene expression is still a scientific and diagnostic problem.
Sebastian Wawrocki, Grzegorz Kielnierowski, Wieslawa Rudnicka, Michal Seweryn, Magdalena Druszczynska   +4 more
doaj   +1 more source

Contribution of Mitochondrial Dysfunction Combined with NLRP3 Inflammasome Activation in Selected Neurodegenerative Diseases

Pharmaceuticals, 2021
Alzheimer’s disease and Parkinson’s disease are the most common forms of neurodegenerative illnesses. It has been widely accepted that neuroinflammation is the key pathogenic mechanism in neurodegeneration.
Anna Litwiniuk, Agnieszka Baranowska-Bik, Anita Domańska, Małgorzata Kalisz, Wojciech Bik   +4 more
doaj   +1 more source

Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability [PDF]

Circulation Research, 2001
Abstract— Interleukin (IL)-18 is the interferon-γ–inducing factor and has other proinflammatory properties. The precise role of IL-18 in immunoinflammatory diseases remains poorly understood. In this study, we show that in vivo electrotransfer of an expression-plasmid DNA encoding for murine IL-18 ...
Z, Mallat, A, Corbaz, A, Scoazec, P, Graber, S, Alouani, B, Esposito, Y, Humbert, Y, Chvatchko, A, Tedgui   +8 more
openaire   +2 more sources

Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Balkan Medical Journal, 2018
Background: Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in ...
Berk Arapi, Burcu Bayoğlu, Müjgan Cengiz, Ahmet Dirican, Serkan Burç Deser, Yerik Junusbekov, Caner Arslan   +6 more
doaj   +1 more source

P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease

Frontiers in Pharmacology, 2021
Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou, Zhichao Zhou, Xiaojing Liu, Xiaojing Liu, Hai-Yan Yin, Hai-Yan Yin, Yong Tang, Yong Tang, Xin Cao, Xin Cao   +9 more
doaj   +1 more source

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases [PDF]

Iranian Journal of Immunology, 2018
Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 ...
Xiaoying Wang, Keye Xu, Sisi Chen, Yan Li, Mingcai Li   +4 more
doaj   +1 more source

Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Ischemia-Induced Neovascularization in Mice Hindlimb [PDF]

Circulation Research, 2002
Identification of factors that may stimulate ischemia-induced neovascularization without increasing atherosclerotic plaque progression is of major therapeutic importance. We hypothesized that interleukin-18 binding protein (IL-18BP), a major antiinflammatory protein with plaque-stabilizing activities, may affect the neovascularization in ...
Ziad, Mallat, Jean-Sébastien, Silvestre, Sophie, Le Ricousse-Roussanne, Laurence, Lecomte-Raclet, Anne, Corbaz, Michel, Clergue, Micheline, Duriez, Véronique, Barateau, Shizuo, Akira, Alain, Tedgui, Gérard, Tobelem, Yolande, Chvatchko, Bernard I, Lévy   +12 more
openaire   +2 more sources

IL-18BP Improves Early Graft Function and Survival in Lewis–Brown Norway Rat Orthotopic Liver Transplantation Model

Biomolecules, 2022
Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological
Qiang Meng, Weikang Wu, Wenjie Zhang, Juzheng Yuan, Long Yang, Xuan Zhang, Kaishan Tao   +6 more
doaj   +1 more source

Correlation between C-reactive protein/albumin ratio and prognosis in patients with lung adenocarcinoma

Journal of International Medical Research, 2022
Objective This study was performed to examine the relationship between the C-reactive protein/albumin ratio (CAR) and the prognosis of patients with lung adenocarcinoma and thus provide a reference for evaluating the prognosis of lung adenocarcinoma ...
Zheng Jia-min, Dai Wei, Lu Ye, Pan Xiang-tao   +3 more
doaj   +1 more source