Results 11 to 20 of about 65,808,146 (287)

Interleukin-18 and interleukin-18 Binding Protein [PDF]

Frontiers in Immunology, 2013
Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
Charles eDinarello, Charles eDinarello, Daniela eNovick, SooHun eKim, SooHun eKim, Gilles eKaplanski, Gilles eKaplanski   +6 more
doaj   +8 more sources

Interleukin-18 binding protein protects against metabolic steatohepatitis. [PDF]

Hepatol Commun
Background: Metabolic dysfunction–associated steatohepatitis (MASH) is a frequent consequence of Western diet consumption and liver steatosis. IL-18 binding protein (IL-18BP) limits the action of interleukin-18 (IL-18). Our work aims to study the unknown role of IL-18BP in MASH progression.
Somm E, Jo Y, Perroud E, Ino F, Lindner K, Kang BE, Veyrat-Durebex C, Bontems F, Visentin F, Fauteux-Daniel S, Förster I, Gavin AC, Pagano S, Vuilleumier N, Ryu D, Gariani K, Gabay C, Jornayvaz FR.   +17 more
europepmc   +4 more sources

High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura

Haematologica, 2009
To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-γ, IL-4 plasma levels and platelet counts ...
Ning-ning Shan, Xiao-juan Zhu, Qian Wang, Chun-yan Wang, Ping Qin, Jun Peng, Ming Hou   +6 more
doaj   +3 more sources

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18 [PDF]

Frontiers in Immunology, 2017
The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP).
Robert Z. Harms, Austin J. Creer, Kristina M. Lorenzo-Arteaga, Katie R. Ostlund, Nora E. Sarvetnick, Nora E. Sarvetnick   +5 more
doaj   +2 more sources

The Role of Interleukin 18/Interleukin 18-Binding Protein in Adult-Onset Still's Disease and Systemic Juvenile Idiopathic Arthritis. [PDF]

J Clin Med, 2022
Interleukin 18 (IL-18) is a pro-inflammatory cytokine of the IL-1 family, whose activity is tightly controlled at the level of production, as well as signalization. Notably, it is buffered by its natural inhibitor, IL-18 binding protein (IL-18BP), which is massively present in circulation in normal and in most pathological conditions, thus preventing ...
Girard-Guyonvarc'h C, Harel M, Gabay C.
europepmc   +4 more sources

Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2002
To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment.Serum samples were obtained before and after methotrexate treatment from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA ...
B, Bresnihan, P, Roux-Lombard, E, Murphy, D, Kane, O, FitzGerald, J-M, Dayer   +5 more
openaire   +3 more sources

Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases

Cytokine, 2022
Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and potent pro-inflammatory activities that are tightly controlled at the level of production and in the extracellular space. Indeed, IL-18 is translated as a leaderless biologically inert pro-peptide that is cleaved by caspase-1 in its N-terminus domain to become active ...
Mathilde Harel, Sébastien Fauteux-Daniel, Charlotte Girard-Guyonvarc'h, Cem Gabay   +3 more
openaire   +2 more sources

Interleukin‐18, IL‐18 binding protein and IL‐18 receptor expression in asthma: a hypothesis showing IL‐18 promotes epithelial cell differentiation

Clinical & Translational Immunology, 2021
Objective In asthma, genome‐wide association studies have shown that interleukin‐18 (IL‐18) receptor 1 gene (IL‐18R1) and sputum IL‐18 are increased during exacerbations. However, the role of the IL‐18 axis in bronchial epithelial function is unclear. To
Davinder Kaur, Latifa Chachi, Edith Gomez, Nicolas Sylvius, Christopher E Brightling   +4 more
doaj   +1 more source

Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis. [PDF]

PLoS ONE, 2010
BACKGROUND: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8+ T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation
Claudia A Nold-Petry, Thomas Lehrnbecher, Andrea Jarisch, Dirk Schwabe, Josef M Pfeilschifter, Heiko Muhl, Marcel F Nold, Marcel F Nold   +7 more
doaj   +1 more source

Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein [PDF]

Proceedings of the National Academy of Sciences, 2008
Human interleukin-18 (hIL-18) is a cytokine that plays an important role in inflammation and host defense against microbes. Its activity is regulated in vivo by a naturally occurring antagonist, the human IL-18-binding protein (IL-18BP). Functional homologs of human IL-18BP are encoded by all orthopoxviruses, including variola virus, the causative ...
Brian, Krumm, Xiangzhi, Meng, Yongchao, Li, Yan, Xiang, Junpeng, Deng   +4 more
openaire   +2 more sources