The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis [PDF]
Frontiers in Immunology, 2023 BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic ...
Sebastien Fauteux-Daniel +17 more
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Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases [PDF]
Biomedicines, 2022 Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park +4 more
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A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. [PDF]
PLoS Pathogens, 2012 Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative ...
Brian Krumm +4 more
doaj +4 more sources
Interleukin-18 and interleukin-18 Binding Protein [PDF]
Frontiers in Immunology, 2013 Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
Charles eDinarello +6 more
doaj +4 more sources
Interleukin-18 binding protein deficiency results in gut microbiota dysbiosis and aggravated diet-induced MASH in mice [PDF]
JHEP ReportsBackground & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) are now the most prevalent hepatic disorders worldwide.
Emmanuel Somm +16 more
doaj +2 more sources
The Role of Interleukin 18/Interleukin 18-Binding Protein in Adult-Onset Still's Disease and Systemic Juvenile Idiopathic Arthritis. [PDF]
J Clin Med, 2022 Interleukin 18 (IL-18) is a pro-inflammatory cytokine of the IL-1 family, whose activity is tightly controlled at the level of production, as well as signalization. Notably, it is buffered by its natural inhibitor, IL-18 binding protein (IL-18BP), which is massively present in circulation in normal and in most pathological conditions, thus preventing ...
Girard-Guyonvarc'h C, Harel M, Gabay C.
europepmc +4 more sources
Acquisition of different transcriptional shear mRNA and biological function of porcine interleukin 18 binding protein in PRRSV infection [PDF]
mBioInterleukin-18 binding protein (IL-18BP), a natural regulator molecule of the pro-inflammatory cytokine interleukin-18 (IL-18), plays an important role in regulating the expression of the cellular immunity factor interferon-γ (IFN-γ).
Hong-zhe Zhao +5 more
doaj +2 more sources
Cloning and expression of interleukin-18 binding protein
FEBS Letters, 1999 Interleukin‐18 binding protein is a novel glycoprotein that we successfully cloned and expressed. First, murine interleukin‐18 binding protein was purified from the sera of mice with endotoxin shock using ligand affinity chromatography. The murine interleukin‐18 binding protein cDNA was cloned after RT‐PCR using mixed primer pair sequences based on ...
K Torigoe, M Kurimoto
exaly +3 more sources
Haematologica, 2009 To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-γ, IL-4 plasma levels and platelet counts ...
Ning-ning Shan +6 more
doaj +3 more sources
Interleukin-18 binding protein protects against metabolic steatohepatitis. [PDF]
Hepatol CommunBackground: Metabolic dysfunction–associated steatohepatitis (MASH) is a frequent consequence of Western diet consumption and liver steatosis. IL-18 binding protein (IL-18BP) limits the action of interleukin-18 (IL-18). Our work aims to study the unknown role of IL-18BP in MASH progression.
Somm E +17 more
europepmc +3 more sources