Results 61 to 70 of about 1,777 (151)
ChemistryEurope, Volume 3, Issue 6, November 11, 2025.Larger‐scale enzymatic synthesis of base‐modified DNA is developed using primer extension with KOD(exo‐) DNA polymerase allowing preparation of milligram amounts of the modified DNA sufficient for NMR structural analysis. Milligram (≈200 nmol) scale enzymatic synthesis of base‐modified DNA is developed based on primer extension using easily accessible ...
Veronika Raindlová +6 more
wiley +1 more source
Identification of small molecule inhibitors of Interleukin-18
Scientific Reports, 2017 Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive immune defense but its aberrant activities are also associated with inflammatory diseases such ...
Brian Krumm +3 more
doaj +1 more source
Journal of Neuroinflammation, 2018 Background Although the mechanisms underlying AD neurodegeneration are not fully understood, it is now recognised that inflammation could play a crucial role in the initiation and progression of AD neurodegeneration.
Paola Italiani +10 more
doaj +1 more source
HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. [PDF]
PLoS ONE, 2018 Interleukin-18 (IL-18) is a pleiotropic cytokine of the IL-1 family with multiple context dependent functions. We and others have shown that HIV infection is accompanied by increased circulating levels of IL-18 along with decreased levels of its ...
Ossama Allam +7 more
doaj +1 more source
Movement Disorders, Volume 40, Issue 10, Page 2199-2208, October 2025.Abstract Background Inhibition of Nod‐like receptor protein 3 (NLRP3) inflammasome within the central nervous system (CNS) is a promising therapeutic target for the treatment of Parkinson's disease (PD). Objectives This phase 1b open‐label study was conducted in elderly healthy volunteers (HV) and PD patients.
Nicholas Clarke +11 more
wiley +1 more source
Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis. [PDF]
PLoS ONE, 2010 BACKGROUND: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8+ T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation
Claudia A Nold-Petry +7 more
doaj +1 more source
Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications
MedComm, Volume 6, Issue 9, September 2025.NK cells eliminate tumors via cytotoxicity and cytokine secretion. Tumor microenvironment‐driven immunosuppression and metabolic reprogramming subvert NK cells’ cytotoxicity. The current clinical strategies to restore NK activity include ex vivo expansion for adoptive transfer, CAR‐NK engineering, TME‐remodeling agents, immune checkpoint blockade ...
Nanzhi Luo +12 more
wiley +1 more source
The Journal of Pathology, Volume 266, Issue 2, Page 177-191, June 2025.Abstract Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a ‘maternal‐foetal rejection’ mechanism, because at least some CHI cases fulfil the criteria for antibody‐mediated ...
Léonie Albersammer +18 more
wiley +1 more source
Advanced Science, Volume 12, Issue 18, May 15, 2025.This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao +16 more
wiley +1 more source