Results 71 to 80 of about 1,777 (151)

Acquisition of different transcriptional shear mRNA and biological function of porcine interleukin 18 binding protein in PRRSV infection

mBio
Interleukin-18 binding protein (IL-18BP), a natural regulator molecule of the pro-inflammatory cytokine interleukin-18 (IL-18), plays an important role in regulating the expression of the cellular immunity factor interferon-γ (IFN-γ).
Hong-zhe Zhao, Chun-yu Liu, Qian-jin Song, Hao Guo, Yong-jun Wen, Feng-xue Wang   +5 more
doaj   +1 more source

Nuclear Transfer using Human CD59 and IL-18BP Double Transgenic Fetal Fibroblasts in Miniature Pigs

Journal of Animal Reproduction and Biotechnology, 2016
Xenotransplantation involves multiple steps of immune rejection. The present study was designed to produce nuclear transfer embryos, prior to the production of transgenic pigs, using fibroblasts carrying transgenes human complement regulatory protein ...
Junghyun Ryu, Minjeong Kim, Jin Seop Ahn, Kwang Sung Ahn, Hosup Shim   +4 more
doaj   +1 more source

Decoys and regulatory "receptors" of the IL-1/Toll Like Receptor superfamily

Frontiers in Immunology, 2013
Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signalling molecules and negative regulators.
Cecilia eGarlanda, Federica eRiva, Eduardo eBonavita, Stefania eGentile, Alberto eMantovani, Alberto eMantovani   +5 more
doaj   +1 more source

Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection

Mediators of Inflammation, 2019
Background. Interleukin- (IL-) 18 is a proinflammatory cytokine related to cardiovascular diseases, including hypertension and atherosclerosis. This study is aimed at determining whether IL-18 is related to aortic dissection (AD) and identifying the ...
Haiying Hu, Guangtai Zhang, Huanli Hu, Wenjing Liu, Jixiang Liu, Shuanli Xin, Xiufeng Zhao, Liying Han, Liping Duan, Xinshun Huang, Chao Chang   +10 more
doaj   +1 more source

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition. [PDF]

MAbs, 2023
Lipinski B, Unmuth L, Arras P, Becker S, Bauer C, Toleikis L, Krah S, Doerner A, Yanakieva D, Boje AS, Klausz K, Peipp M, Siegmund V, Evers A, Kolmar H, Pekar L, Zielonka S.   +16 more
europepmc   +1 more source

IL-6 and IL-18 cytokine traps in COVID-19

Инфекция и иммунитет
Cytokines are mediators of immunity that regulate inflammation. Intensity of inflammatory process is strongly dependent on the cytokine type and duration of its effect.
A. A. Korotaeva, Elena V. Samoilova, D. A. Chepurnova, N. V. Pogosova, D. T. Kuchiev, F. N. Paleev   +5 more
doaj   +1 more source

Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti–CTLA-4 in renal cell carcinoma

JCI Insight
The cytokine IL-18 has immunostimulatory effects but is negatively regulated by a secreted binding protein, IL-18BP, that limits IL-18’s anticancer efficacy.
David A. Schoenfeld, Dijana Djureinovic, David G. Su, Lin Zhang, Benjamin Y. Lu, Larisa Kamga, Jacqueline E. Mann, John D. Huck, Michael Hurwitz, David A. Braun, Lucia Jilaveanu, Aaron M. Ring, Harriet M. Kluger   +12 more
doaj   +1 more source

IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice. [PDF]

Sci Rep, 2020
Li X, Cui W, Hull L, Wang L, Yu T, Xiao M.   +5 more
europepmc   +1 more source

The imbalance of IL-18/IL-18BP in patients with systemic juvenile idiopathic arthritis [PDF]

Acta Biochimica et Biophysica Sinica, 2013
Ou, Chen, Ningning, Shan, Xiaobo, Zhu, Yibiao, Wang, Peng, Ren, De'e, Wei, Ruopeng, Sun   +6 more
openaire   +2 more sources

IL-18 and IL-18BP in Amyotrophic Lateral Sclerosis

Frontiers in Immunology, 2013
Boraschi Diana, Bossu' Paola, Borroni Barbara, Siciliano Gabriele, Migliorini Paola, Italiani Paola, Giungato Paola   +6 more
openaire   +1 more source