Results 31 to 40 of about 1,777 (151)

High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura

Haematologica, 2009
To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-γ, IL-4 plasma levels and platelet counts ...
Ning-ning Shan, Xiao-juan Zhu, Qian Wang, Chun-yan Wang, Ping Qin, Jun Peng, Ming Hou   +6 more
doaj   +1 more source

IL-27 Regulates IL-18 binding protein in skin resident cells. [PDF]

PLoS ONE, 2012
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Miriam Wittmann, Rosella Doble, Malte Bachmann, Josef Pfeilschifter, Thomas Werfel, Heiko Mühl   +5 more
doaj   +1 more source

IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria

BMC Infectious Diseases, 2021
Background Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes.
Kari Otterdal, Aase Berg, Annika E. Michelsen, Arne Yndestad, Sam Patel, Ida Gregersen, Bente Halvorsen, Thor Ueland, Nina Langeland, Pål Aukrust   +9 more
doaj   +1 more source

Expression, Purification and Structural Analysis of Human IL-18 Binding Protein: A Potent Therapeutic Molecule for Allergy

Allergology International, 2008
Background: While interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses, it can also cause severe allergic inflammatory reactions. Thus it is a molecule currently being targeted for therapy.
Takeshi Kimura, Zenichiro Kato, Hidenori Ohnishi, Hidehito Tochio, Masahiro Shirakawa, Naomi Kondo   +5 more
doaj   +1 more source

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18

Frontiers in Immunology, 2017
The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP).
Robert Z. Harms, Austin J. Creer, Kristina M. Lorenzo-Arteaga, Katie R. Ostlund, Nora E. Sarvetnick, Nora E. Sarvetnick   +5 more
doaj   +1 more source

Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma

Mediators of Inflammation, 2014
Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian
Liat Medina, Alex Rabinovich, Benjamin Piura, Victor Dyomin, Ruthy Shaco Levy, Mahmoud Huleihel   +5 more
doaj   +1 more source

A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade

Frontiers in Immunology, 2023
Human urinary proteins are a goldmine of natural proteins a feature that simplifies their translation to biologics. Combining this goldmine together with the ligand-affinity-chromatography (LAC) purification method, proved a winning formula in their ...
Daniela Novick
doaj   +1 more source

Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis

Cell Reports Medicine
Summary: Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease characterized by inflammation and fibrosis, with enhanced interleukin-18 (IL-18) signaling. IL-18-binding protein (IL-18BP) neutralizes IL-18, but its therapeutic
Dong-Hyun Kim, Gona Choi, Eun-Bi Song, Hanna Lee, Jaehui Kim, Young-Saeng Jang, JinJoo Park, Susan Chi, Jaekyu Han, Sun-Mi Kim, Dongyoon Kim, Soo Han Bae, Hye Won Lee, Jun Yong Park, Seung Goo Kang, Sang-Hoon Cha, Yong-Hyun Han   +16 more
doaj   +1 more source

Interleukin-18 in Inflammatory Kidney Disease

Frontiers in Medicine, 2021
Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj   +1 more source

Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation

Diagnostics, 2021
Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous ...
Anna Kyriakoudi, Nikoletta Rovina, Ourania Koltsida, Eirini Kostakou, Elissavet Konstantelou, Matina Kardara, Maria Kompoti, Anastasios Palamidas, Georgios Kaltsakas, Antonia Koutsoukou   +9 more
doaj   +1 more source