Results 11 to 20 of about 1,777 (151)
IL-18 and IL-18BP: A Unique Dyad in Health and Disease [PDF]
International Journal of Molecular SciencesInterleukin-18 (IL-18) serves a dual function in the immune system, acting as a “double-edged sword” cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathologies characterized by elevated IL-18, recently proposed to be termed IL-18opathies, highlight the therapeutic ...
Daniela Novick
exaly +4 more sources
Journal of Experimental Medicine, 2019 Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and ...
Michael S Diamond
exaly +5 more sources
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy [PDF]
Nature, 2020 Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating ...
Ting Zhou +2 more
exaly +5 more sources
Inherited IL-18BP deficiency in human fulminant viral hepatitis [PDF]
Journal of Experimental Medicine, 2019 Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in IL18BP, which encodes ...
Bertrand Boisson +2 more
exaly +7 more sources
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia [PDF]
Journal of Neuroinflammation, 2012 Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria +7 more
doaj +5 more sources
The Journal of Pathology: Clinical ResearchIntraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh +7 more
doaj +2 more sources
Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy. [PDF]
J Immunother CancerBackground The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its susceptibility to neutralization by IL-18 binding ...
Bainbridge TW +20 more
europepmc +2 more sources
Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity. [PDF]
Front ImmunolCheckpoint inhibitors targeting the PD-1/PD-L1 axis have revolutionized cancer immunotherapy, yet response rates remain limited. To enhance efficacy, next-generation approaches target T cell-activating cytokines to PD-1 via antibodies.
Zhou X +4 more
europepmc +2 more sources
Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R [PDF]
Journal of Cellular and Molecular Medicine, 2018 Shaoheng He, Junling Wang, Hua Xie
exaly +2 more sources
Interleukin-18 Binding Protein (IL-18BP) Deficiency Affects Lymphocyte Activation and IL-18 Expression in a Mouse Model of Liver Inflammation. [PDF]
Eur J ImmunolEuropean Journal of Immunology, Volume 55, Issue 4, April 2025.
Devisme C +7 more
europepmc +2 more sources