Results 21 to 30 of about 1,777 (151)
Effect of IL-18BP on anxiety-like behavior in traumatic brain injury rats and its mechanism [PDF]
Xin yixue, 2023 Objective To evaluate the effect of IL-18 binding protein （IL-18BP） on anxiety-like behavior after traumatic brain injury （TBI） in rats and its related mechanism.
Li Yan, Qi Manman, Jiao Baojie, Li Chunlei, Wang Chunlei, Chang Yulin
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic ...
Sebastien Fauteux-Daniel +17 more
doaj +1 more source
The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice. [PDF]
PLoS ONE, 2013 Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis.To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus ...
Xueting Shao +9 more
doaj +1 more source
Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases
Biomedicines, 2022 Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park +4 more
doaj +1 more source
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Journal of Translational Medicine, 2021 Background Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in ...
Hong Ki Min +5 more
doaj +1 more source
Toxics, 2022 Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui +6 more
doaj +1 more source
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application. [PDF]
Immune NetwIL-18 binding protein (IL-18BP) was originally discovered in 1999 while attempting to identify an IL-18 receptor ligand binding chain (also known as IL-18Rα) by subjecting concentrated human urine to an IL-18 ligand affinity column. The IL-18 ligand chromatography purified molecule was analyzed by protein microsequencing. The result revealed a novel 40
Kim S, Yu H, Azam T, Dinarello CA.
europepmc +3 more sources
Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
europepmc +2 more sources
Clinical & Translational Immunology, 2021 Objective In asthma, genome‐wide association studies have shown that interleukin‐18 (IL‐18) receptor 1 gene (IL‐18R1) and sputum IL‐18 are increased during exacerbations. However, the role of the IL‐18 axis in bronchial epithelial function is unclear. To
Davinder Kaur +4 more
doaj +1 more source