Results 51 to 60 of about 741,206 (288)
Identification of small molecule inhibitors of Interleukin-18
Scientific Reports, 2017 Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive immune defense but its aberrant activities are also associated with inflammatory diseases such ...
Brian Krumm +3 more
doaj +1 more source
A Poxvirus Protein That Binds to and Inactivates IL-18, and Inhibits NK Cell Response [PDF]
The Journal of Immunology, 2000 Abstract IL-18 induces IFN-γ and NK cell cytotoxicity, making it a logical target for viral antagonism of host defense. We demonstrate that the ectromelia poxvirus p13 protein, bearing homology to the mammalian IL-18 binding protein, binds IL-18, and inhibits its activity in vitro.
T L, Born +8 more
openaire +2 more sources
Immunologic Function and Molecular Insight of Recombinant Interleukin-18. [PDF]
PLoS ONE, 2016 In recent years, cytokine-mediated therapy has emerged as further advance alternative in cancer therapy. Interleukin-18 (IL-18) has exhibited interesting anti-cancer properties especially when combined with IL-12.
Jirakrit Saetang +5 more
doaj +1 more source
Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba [PDF]
, 2013 Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly ...
Petrovic-Stojanovska, Biljana +3 more
core +1 more source
IL-6 and IL-18 cytokine traps in COVID-19
Инфекция и иммунитетCytokines are mediators of immunity that regulate inflammation. Intensity of inflammatory process is strongly dependent on the cytokine type and duration of its effect.
A. A. Korotaeva +5 more
doaj +1 more source
Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein [PDF]
The Journal of Immunology, 2003 Abstract IL-18 is an important cytokine in autoimmune and inflammatory diseases through the induction of IFN-γ, TNF-α, and IL-1. We report herein that collagen-induced arthritis (CIA) in mice is inhibited by treatment with murine IL-18 binding protein (mIL-18BP).
Nirmal K, Banda +7 more
openaire +2 more sources
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Niobium uptake and release by bacterial ferric ion binding protein [PDF]
, 2010 Ferric ion binding proteins (Fbps) transport FeIII across the periplasm and are vital for the virulence of many Gram negative bacteria. Iron(III) is tightly bound in a hinged binding cleft with octahedral coordination geometry involving binding to ...
Dominic Campopiano +12 more
core +1 more source
SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
Signal Transduction and Targeted Therapy, 2023 Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling ...
Shuxin Liang +16 more
doaj +1 more source
Future Pharmacology, 2023 The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) protein 3 (NLRP3) inflammasome pathway is believed to mediate chronic inflammation in diabetic retinopathy (DR); however, its impact on the progression of DR remains to be elucidated.
Charisse Y.-J. Kuo +4 more
doaj +1 more source