Results 51 to 60 of about 72,835,347 (270)

Interleukin-18 (IL-18) engineered for half-life extension and resistance to IL-18 binding protein (IL-18BP) to enhance anti-cancer therapeutic potential.

Cytokine
Recombinant interleukin-18 (IL-18) holds promise as a therapeutic for oncology, as a robust activator of adaptive and innate immune cells and a potent producer of IFN-γ.
K. Dreaden, S. Pearson, P. Gurel, R. G. Newman, Yan-Chun Zhao, Chun-Hua Wang, J. Heiber, S. S. Donatelli, J. Chamoun, Mark Whitmore   +9 more
semanticscholar   +1 more source

Identification of small molecule inhibitors of Interleukin-18

Scientific Reports, 2017
Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive immune defense but its aberrant activities are also associated with inflammatory diseases such ...
Brian Krumm, Xiangzhi Meng, Yan Xiang, Junpeng Deng   +3 more
doaj   +1 more source

Orthopoxvirus IL-18 Binding Proteins: Affinities and Antagonist Activities

Virology, 2001
The affinities of purified recombinant human IL-18 binding protein (BP) and ectromelia and cowpox virus homologs for human and murine IL-18 were compared by plasmon resonance. The dissociation constants of human IL-18BP were similar for murine and human IL-18. By contrast, the dissociation constants of the viral proteins for murine IL-18 were 12- to 50-
Calderara, Silvio, Xiang, Yan, Moss, Bernard   +2 more
openaire   +2 more sources

Immunologic Function and Molecular Insight of Recombinant Interleukin-18. [PDF]

PLoS ONE, 2016
In recent years, cytokine-mediated therapy has emerged as further advance alternative in cancer therapy. Interleukin-18 (IL-18) has exhibited interesting anti-cancer properties especially when combined with IL-12.
Jirakrit Saetang, Aekkachai Puseenam, Niran Roongsawang, Supayang Piyawan Voravuthikunchai, Surasak Sangkhathat, Varomyalin Tipmanee   +5 more
doaj   +1 more source

IL-6 and IL-18 cytokine traps in COVID-19

Инфекция и иммунитет
Cytokines are mediators of immunity that regulate inflammation. Intensity of inflammatory process is strongly dependent on the cytokine type and duration of its effect.
A. A. Korotaeva, Elena V. Samoilova, D. A. Chepurnova, N. V. Pogosova, D. T. Kuchiev, F. N. Paleev   +5 more
doaj   +1 more source

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Signal Transduction and Targeted Therapy, 2023
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling ...
Shuxin Liang, Changlei Bao, Zi Yang, Shiyun Liu, Yanan Sun, Weitao Cao, Ting Wang, Tae-Hwi Schwantes-An, John S. Choy, Samisubbu Naidu, Ang Luo, Wenguang Yin, Stephen M. Black, Jian Wang, Pixin Ran, Ankit A. Desai, Haiyang Tang   +16 more
doaj   +1 more source

Altered expression of IL‐18 binding protein and IL‐18 receptor in basophils and mast cells of asthma patients

Scandinavian Journal of Immunology, 2018
IL‐18 is likely to contribute to asthma. However, little is known regarding the role of IL‐18 binding protein (BP) and IL‐18 receptor (R) in asthma. Because the action of IL‐18 in the body is regulated by IL‐18BP and mast cells and basophils are key cell
Zhi-Yun Wang, Zhining Liu, Ling Wang, Junling Wang, Li-Ping Chen, Hua Xie, Hui-Yun Zhang, Shao-Heng He   +7 more
semanticscholar   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Regulation of IL-18 binding protein by IFN-gamma [PDF]

, 2003
In this study we investigated the regulation of IL-18BPa by IFN-y in the context of colon cancer and human autoimmune diseases. IL-18BPa is a naturally occuring inhibitor that counteracts IL-18 bioactivity.
Paulukat, Jens
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