Results 51 to 60 of about 70,619,624 (286)

CONTENTS OF CYTOKINES IN BLOOD OF THE PATIENTS WITH LOCAL FROSTBITES

Медицинская иммунология, 2014
. Cytokines provide important connecting links between immunity, blood clotting, and nonspecific resistance that become altered in local frostbites. The aim of study was to determine the contents of cytokines in blood of patients with local frostbites at
K. G. Shapovalov, E. A. Tomina, M. I. Mihailichenko, V. A. Sizonenko, Y. A. Vitkovsky   +4 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Associação do gene IL-18 com Artrite Reumatóide em um estudo epidemiológico no estado de Santa Catarina: estudo caso-controle [PDF]

, 2009
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A doença auto-imune é causada por uma disfunção no sistema imunológico, onde as células de defesa do organismo reconhecem moléculas próprias como ...
Farias, Ticiana Della Justina
core  

IL-18 (Interleukin-18) produced by renal tubular epithelial cells promotes renal inflammation and injury during deoxycorticosterone/salt-induced hypertension in mice

, 2021
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage is unknown. We examined the role of IL-18 in the development of renal inflammation and injury in a mouse model of low-renin ...
Diep, Henry, Brooke Huuskes (9495947), Sharma, Prerna, Guzik, Tomasz, Drummond, Grant R., Yeong H Ling (15393518), Saini, Narbada, Tomasz J Guzik (8414667), Arumugam, Thiruma V., Krishnan, Shalini M., Jordyn Thomas (9494048), Henry Diep (9491633), Vinh, Antony, Thiruma Arumugam (9481307), OConnor, Paul M., Ferens, Dorota M., Eicke Latz (416789), Dorota M Ferens (19187941), Antony Vinh (9491777), Hickey, Michael J., Sobey, Christopher G., Prerna Sharma (287982), Mansell, Ashley, Huuskes, Brooke, Grant Drummond (9477542), Jelinic, Maria, Narbada Saini (9481148), Thomas, Jordyn M., Shalini M Krishnan (15393515), Christopher Sobey (7138634), Kemp-Harper, Barbara K., Maria Jelinic (9480407), Michael J Hickey (11403662), Ashley Mansell (18571180), Ling, Yeong H., Paul M O’Connor (21388781), Latz, Eicke, Barbara K Kemp-Harper (15137629), Eicke Latz, Yeong H. Ling, Dorota M. Ferens, Prerna Sharma, Tomasz J. Guzik, Barbara K. Kemp-Harper, Ashley Mansell, Shalini M. Krishnan, Christopher G. Sobey, Grant R. Drummond, Thiruma V. Arumugam, Paul M. O’Connor, Antony Vinh, Brooke Huuskes, Maria Jelinic, Jordyn M. Thomas, Henry Diep, Narbada Saini, Michael J. Hickey   +56 more
core   +1 more source

Are IL-1 family cytokines important in management of sickle cell disease in Sub-Saharan Africa patients?

Frontiers in Immunology, 2023
IntroductionSickle cell disease (SCD) is the most common genetic disease found in Africa and throughout the world. It is responsible for a high rate of hemolysis, systemic inflammation, and modulation of the immune system with the involvement of ...
Liliane K. Siransy, Liliane K. Siransy, Romuald S. Dasse, Honoré Adou, Patricia Kouacou, Sidonie Kouamenan, Yassongui Sekongo, Richard Yeboah, Charlene Memel, Aniella Assi-Sahoin, Salimata Y. Moussa, Doris Oura, Jocelyne Seri   +12 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB [PDF]

, 2019
BackgroundCurrently, there are serious limitations in the direct diagnosis of active tuberculosis (ATB). We evaluated the levels of the IL-18/IL-37/IP-10 signalling complex proteins in Mycobacterium tuberculosis (M.tb)-specific antigen-stimulated ...
Wlodarczyk, Marcin, Michal Seweryn (791451), Wawrocki, Sebastian, Sebastian Wawrocki (4720968), Magdalena Druszczynska (629666), Sebastian Wawrocki, Wieslawa Rudnicka (629662), Grzegorz Kielnierowski, Druszczynska, Magdalena, Michal Seweryn, Magdalena Druszczynska, Seweryn, Michał, Grzegorz Kielnierowski (629664), Kielnierowski, Grzegorz, Wieslawa Rudnicka, Marcin Wlodarczyk, Marcin Wlodarczyk (629661), Rudnicka, Wieslawa   +17 more
core   +1 more source