Results 1 to 10 of about 269,474 (266)

Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice

Frontiers in Immunology, 2022
Natural killer (NK) cells are important effectors of the innate immune system and participate in the first line of defense against infections and tumors.
Neha D. Patil, Neha D. Patil, Olivia Domingues, Cécile Masquelier, Maud Theresine, Oceane Schlienger, Clinton Njinju Amin Asaba, Marine Thomas, Carole Seguin-Devaux, Hortense Slevogt, Markus Ollert, Markus Ollert, Jacques Zimmer   +12 more
doaj   +1 more source

Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Frontiers in Immunology, 2021
In recent years, chimeric antigen receptor T cells (CAR-T cells) have been faced with the problems of weak proliferation and poor persistence in the treatment of some malignancies.
Zhengchao Zhang, Zhengchao Zhang, Lele Miao, Lele Miao, Zhijian Ren, Zhijian Ren, Futian Tang, Futian Tang, Yumin Li, Yumin Li   +9 more
doaj   +1 more source

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter [PDF]

Nature Medicine, 2015
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in mice. Here, we show that absence of the IL18 receptor (IL18r) does not affect atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice, nor does it affect IL18 cell surface binding to or signaling in ...
Wang, J., Sun, C., Gerdes, N., Liu, C., Liao, M., Liu, J., Shi, M.A., He, A., Zhou, Y., Sukhova, G.K., Chen, H., Cheng, X.W., Kuzuya, M., Murohara, T., Zhang, J., Cheng, X., Jiang, M., Shull, G.E., Rogers, S., Yang, C.L., Ke, Q., Jelen, S.K., Bindels, R.J.M., Ellison, D.H., Jarolim, P., Libby, P., Shi, G.P.   +26 more
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Interleukin-18 and interleukin-18 receptor-α expression in allergic asthma [PDF]

European Respiratory Journal, 2011
To the Editors: The inflammatory process in allergic asthma is initiated by T-helper (Th) type-2 cells, which produce a repertoire of cytokines, including interleukin (IL)-4, IL-5, IL-9 and IL-13, which are necessary for immunoglobulin (Ig)E production, airway eosinophilia and goblet cell hyperplasia [1].
H, Imaoka, G M, Gauvreau, R M, Watson, S G, Smith, B, Dua, A J, Baatjes, K, Howie, T, Hoshino, K J, Killian, H, Aizawa, P M, O'Byrne   +10 more
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The Effects of Pro-Inflammatory Cytokines on Human Body and Their Relation with Diseases (Review Article)

Academic Science Journal, 2023
Cytokines are important mediators in inflammatory disorders that affect the entire body. Signaling molecules called pro-inflammatory cytokines, also known as inflammatory cytokines, are released by the immune system cells including macrophages and T ...
Khalid Shaalan Sahab , Mohammed Asaad Mahdi, Ammar M. K. AL-Azzawi   +2 more
doaj   +1 more source

Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation [PDF]

Nature Immunology, 2006
T helper type 1 (T(H)1) lymphocytes are considered to be the main pathogenic cell type responsible for organ-specific autoimmune inflammation. As interleukin 18 (IL-18) is a cofactor with IL-12 in promoting T(H)1 cell development, we examined the function of IL-18 and its receptor, IL-18R, in autoimmune central nervous system inflammation.
Gutcher, I, Urich, E, Wolter, K, Prinz, M, Becher, B   +4 more
openaire   +5 more sources

Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation

Nature Communications, 2022
Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue.
Xian Zhang, Songyuan Luo, Minjie Wang, Qiongqiong Cao, Zhixin Zhang, Qin Huang, Jie Li, Zhiyong Deng, Tianxiao Liu, Cong-Lin Liu, Mathilde Meppen, Amelie Vromman, Richard A. Flavell, Gökhan S. Hotamışlıgil, Jian Liu, Peter Libby, Zhangsuo Liu, Guo-Ping Shi   +17 more
doaj   +1 more source

Purification and Characterization of the Human Interleukin-18 Receptor [PDF]

Journal of Biological Chemistry, 1997
Interleukin (IL)-18 was identified as a molecule that induces IFN-gamma production and enhances NK cell cytotoxicity. In this paper, we report upon the purification and characterization of human IL-18 receptor (hIL-18R). We selected the Hodgkin's disease cell line, L428, as the most strongly hIL-18R-expressing cell line based on the results of binding ...
K, Torigoe, S, Ushio, T, Okura, S, Kobayashi, M, Taniai, T, Kunikata, T, Murakami, O, Sanou, H, Kojima, M, Fujii, T, Ohta, M, Ikeda, H, Ikegami, M, Kurimoto   +13 more
openaire   +2 more sources

NLRP3 inflammasome: key mediator of neuroinflammation in murine Japanese encephalitis. [PDF]

PLoS ONE, 2012
Japanese Encephalitis virus (JEV) is a common cause of acute and epidemic viral encephalitis. JEV infection is associated with microglial activation resulting in the production of pro-inflammatory cytokines including Interleukin-1 β (IL-1β) and ...
Deepak Kumar Kaushik, Malvika Gupta, Kanhaiya Lal Kumawat, Anirban Basu   +3 more
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Perspective: Daniela Novick, cytokines and their receptors

Frontiers in Immunology, 2023
This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several ...
Pietro Ghezzi, Giamila Fantuzzi, Charles A. Dinarello   +2 more
doaj   +1 more source