Results 21 to 30 of about 5,465,732 (298)

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Baeuerle, Patrick A., Kaspers, Bernd, Kirsten Schneider, Schneider, Kirsten, Baeuerle, Daniela, Daniela Baeuerle, Kirsten C. Weining, Puehler, Florian, Elvers, Sandra, Weining, Kirsten C., Florian Puehler, Sandra Elvers, Bernd Kaspers   +15 more
core   +1 more source

Constitutive expression of Interleukin-18 and Interleukin-18 receptor mRNA in tumour derived human B-cell lines [PDF]

Clinical and Experimental Immunology, 2004
SUMMARYInterleukin-18 (IL-18) is a pro-inflammatory cytokine involved in the Th1 immune response and expressed by a variety of cell types. IL-18 is a member of the IL-1 family and plays an important role in autoimmune diseases and inflammation. Using reverse transcriptase-polymerase chain reaction (RT-PCR) mRNA expression of IL-18, IL-18 receptor alpha
S L, Lorey, Y C, Huang, V, Sharma
openaire   +2 more sources

Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

Mediators of Inflammation, 2015
Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects.
Luciane Alarcão Dias-Melicio, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Marjorie Assis Golim, Angela Maria Victoriano Campos Soares   +4 more
doaj   +1 more source

Interleukin 18 in the CNS

Journal of Neuroinflammation, 2010
Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory ...
Sugama Shuei, Cervia Davide, Alboni Silvia, Conti Bruno   +3 more
doaj   +1 more source

Priming by recombinant chicken interleukin-2 induces selective expression of IL-8 and IL-18 mRNA in chicken heterophils during receptor-mediated phagocytosis of opsonized and nonopsonized Salmonella enterica serovar enteritidis [PDF]

, 2003
Heterophils, the principal avian polymorphonuclear leukocytes (PMNs) equivalent to the mammalian neutrophil, function as professional phagocytes against bacterial infections, mediate acute inflammation, and respond to cytokine stimulation to aid in ...
Michael H Kogut, Pete Kaiser, Kogut, Michael H, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma [PDF]

European Journal of Human Genetics, 2008
The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for asthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark,
Zhu, Guohua, Whyte, Moira K B, Vestbo, Jørgen, Carlsen, Karin, Carlsen, Kai-Håkon, Lenney, Warren, Silverman, Michael, Helms, Peter, Pillai, Sreekumar G   +8 more
openaire   +4 more sources

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate [PDF]

, 2004
IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sj&
Blades, Mark C, I. B. Mcinnes, Conigliaro, Paola, Paola Conigliaro, Mcinnes, I, Iain B McInnes, Priori, R, Barone, Francesca; id_orcid, Pittoni, Valerio, M. C. Blades, Pitzalis, C., Mark C Blades, Priori, R., M. Bombardieri, C. Pitzalis, ALESSANDRI, cristiano, Alessandri, C., Cristiano Alessandri, Bombardieri, M, Alessandri, C, VALESINI, Guido, McInnes, I B, Roberta Priori, Valesini, G., R. Priori, Conigliaro, P., Bombardieri, M., F. Barone, Valesini, G, Blades, M.C., P. Conigliaro, Blades, M, Pitzalis, C, V. Pittoni, Blades, M C, Pittoni, P., Pitzalis, Costantino, Michele Bombardieri, Conigliaro, P, Blades, MC, Pittoni, V, Bombardieri, Michele, Priori, Roberta, Barone, F., McInnes, I.B., Guido Valesini, Francesca Barone, McInnes, IB, McInnes, Iain B, Valerio Pittoni, Barone, F, Costantino Pitzalis   +51 more
core   +1 more source

Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer

Biomedical Reports, 2015
Esophageal cancer is the fourth leading cause of cancer-associated fatalities and the fourth most commonly diagnosed cancer. In addition to environmental risk factors, genetic factors may have a significant role in esophageal cancer carcinogenesis. A hospital-based case-control study was conducted to evaluate the genetic effects of functional single ...
Jingfeng, Zhu, Chao, Liu, Xiao, Teng, Jun, Yin, Liang, Zheng, Liming, Wang, Weifeng, Tang, Haiyong, Gu, Bing, Gu, Liang, Chen   +9 more
openaire   +3 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells [PDF]

, 2012
Background: Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Anderson, G., Anderson George, Ojala, J.O., Sutinen, E.M., Pirttilä Tuula, Antero Salminen, Salminen Antero, Johanna O Ojala, Salminen, A., Elina M Sutinen, George Anderson, Tuula Pirttilä, Pirttilä, T., Sutinen Elina M, Ojala Johanna O   +14 more
core   +2 more sources