Results 21 to 30 of about 269,474 (266)

Interleukin 18 in the CNS

Journal of Neuroinflammation, 2010
Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory ...
Sugama Shuei, Cervia Davide, Alboni Silvia, Conti Bruno   +3 more
doaj   +1 more source

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma [PDF]

European Journal of Human Genetics, 2008
The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for asthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark,
Zhu, Guohua, Whyte, Moira K B, Vestbo, Jørgen, Carlsen, Karin, Carlsen, Kai-Håkon, Lenney, Warren, Silverman, Michael, Helms, Peter, Pillai, Sreekumar G   +8 more
openaire   +4 more sources

Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer

Biomedical Reports, 2015
Esophageal cancer is the fourth leading cause of cancer-associated fatalities and the fourth most commonly diagnosed cancer. In addition to environmental risk factors, genetic factors may have a significant role in esophageal cancer carcinogenesis. A hospital-based case-control study was conducted to evaluate the genetic effects of functional single ...
Jingfeng, Zhu, Chao, Liu, Xiao, Teng, Jun, Yin, Liang, Zheng, Liming, Wang, Weifeng, Tang, Haiyong, Gu, Bing, Gu, Liang, Chen   +9 more
openaire   +3 more sources

The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases [PDF]

International Neurourology Journal, 2012
Among a number of innate receptors, the nucleotide-binding domain leucine-rich repeat containing (NLR) nucleotide oligomerization domain (NOD)-like receptor families are involved in the recognition of cytosolic pathogen- or danger-associated molecules ...
Chul-Su Yang, Dong-Min Shin, Eun-Kyeong Jo   +2 more
doaj   +1 more source

NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer

Frontiers in Oncology, 2020
The tumor microenvironment (TME) is crucial in cancer onset, progression and response to treatment. It is characterized by an intricate interaction of immune cells and cytokines involved in tumor development.
Margherita Sonnessa, Antonella Cioffi, Oronzo Brunetti, Nicola Silvestris, Nicola Silvestris, Francesco A. Zito, Concetta Saponaro, Anita Mangia   +7 more
doaj   +1 more source

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases

Biomedicines, 2022
Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park, Yasmin Hisham, Hyun Mu Shin, Su Cheong Yeom, Soohyun Kim   +4 more
doaj   +1 more source

Expression of Interleukin-18 Receptor mRNA in the Mouse Endometrium

Journal of Reproduction and Development, 2007
Interleukin-18 (IL-18) is a proinflammatory cytokine involved in chronic inflammation, autoimmune diseases, and a variety of cancers, and is expressed in mouse uteri. Our previous study suggested that IL-18 acts as a paracrine factor, regulating endometrial function. To elucidate the physiological roles of IL-18 in the mouse endometrium, the expression
OTSUKI, Mariko, KUSUMOTO, Kenji, MURAKAMI, Yousuke, KANAYAMA, Munetoshi, TAKEUCHI, Sakae, TAKAHASHI, Sumio   +5 more
openaire   +3 more sources

Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2011
AbstractIntroductionThere has been no report in the literature of a soluble form of interleukin (IL)-18 receptor α (IL-18Rα). In this study, we evaluated the levels and characteristics of soluble IL-18Rα (sIL-18Rα) in the sera of patients with rheumatoid arthritis (RA) and compared these results to control populations.MethodsThe sIL-18Rα complex was ...
Takei, Satoko, Hoshino, Tomoaki, Matsunaga, Kazuko, Sakazaki, Yuki, Sawada, Masanori, Oda, Hanako, Takenaka, Shin-ichi, Imaoka, Haruki, Kinoshita, Takashi, Honda, Seiyo, Ida, Hiroaki, Fukuda, Taka-aki, Aizawa, Hisamichi   +12 more
openaire   +2 more sources

Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Frontiers in Immunology, 2021
Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type
Chunren Meng, Chunren Meng, Chufeng Gu, Chufeng Gu, Shuai He, Shuai He, Tong Su, Tong Su, Thashi Lhamo, Deji Draga, Qinghua Qiu, Qinghua Qiu, Qinghua Qiu   +12 more
doaj   +1 more source

The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis

Mediators of Inflammation, 2017
The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by ...
Bunsoon Choi, Chang-Hee Suh, Hyoun-Ah Kim, Hasan M. Sayeed, Seonghyang Sohn   +4 more
doaj   +1 more source