Results 31 to 40 of about 5,465,732 (298)

Truncated Chicken Interleukin-1β with Increased Biologic Activity [PDF]

, 2003
Chicken interleukin-1β (ChIL-1β) is synthesized as a precursor molecule that unlike its mammalian counterpart, lacks a typical caspase-1 cleavage site. Therefore, it was unclear if proteolytic cleavage of ChIL-1β can occur and if cleavage might modulate ...
Erno Duda, Zsuzsa Gyorfy, Duda, Erno, Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Annette Ohnemus, Kaspers, Bernd, Gyorfy, Zsuzsa, Ohnemus, Annette, Bernd Kaspers   +10 more
core   +1 more source

The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases [PDF]

International Neurourology Journal, 2012
Among a number of innate receptors, the nucleotide-binding domain leucine-rich repeat containing (NLR) nucleotide oligomerization domain (NOD)-like receptor families are involved in the recognition of cytosolic pathogen- or danger-associated molecules ...
Chul-Su Yang, Dong-Min Shin, Eun-Kyeong Jo   +2 more
doaj   +1 more source

Role of Interleukin-18 in vascular injury: a new pharmacological target for the prevention of restenosis [PDF]

, 2006
Background: Studies in humans as well as in animal models suggest that interleukin-18 (IL-18) plays a crucial role in vascular pathologies. IL-18 is a strong predictor of cardiovascular death in angina and is involved in atherotic plaque destabilization.
Grassia, Gianluca
core   +1 more source

NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer

Frontiers in Oncology, 2020
The tumor microenvironment (TME) is crucial in cancer onset, progression and response to treatment. It is characterized by an intricate interaction of immune cells and cytokines involved in tumor development.
Margherita Sonnessa, Antonella Cioffi, Oronzo Brunetti, Nicola Silvestris, Nicola Silvestris, Francesco A. Zito, Concetta Saponaro, Anita Mangia   +7 more
doaj   +1 more source

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases

Biomedicines, 2022
Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park, Yasmin Hisham, Hyun Mu Shin, Su Cheong Yeom, Soohyun Kim   +4 more
doaj   +1 more source

Expression of Interleukin-18 Receptor mRNA in the Mouse Endometrium

Journal of Reproduction and Development, 2007
Interleukin-18 (IL-18) is a proinflammatory cytokine involved in chronic inflammation, autoimmune diseases, and a variety of cancers, and is expressed in mouse uteri. Our previous study suggested that IL-18 acts as a paracrine factor, regulating endometrial function. To elucidate the physiological roles of IL-18 in the mouse endometrium, the expression
OTSUKI, Mariko, KUSUMOTO, Kenji, MURAKAMI, Yousuke, KANAYAMA, Munetoshi, TAKEUCHI, Sakae, TAKAHASHI, Sumio   +5 more
openaire   +3 more sources

Differential effects of age on chicken heterophil functional activation by recombinant chicken interleukin-2 [PDF]

, 2002
Interleukin-2 (IL-2) exercises an array of biological effects on many cells including the functional activation of cells of the innate immune response.
Pete Kaiser, Kogut, Michael, Michael Kogut, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]

, 2008
Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea, Garcia Parajo, M.F., van Dijk, E.M.H.P., Jenei, Attila, Andrea Bodnár, Thomas A. Waldmann, Garcia-Parajo, Maria F., Hulst, Niek F., van, Sándor Damjanovich, Attila Jenei, Bakker, B. I. de, van Hulst, N.F., Damjanovich, Sándor, Dóczy-Bodnár, Andrea, György Vámosi, Dijk, Erik M. H. P., van, Waldmann, Thomas A., María F. Garcia-Parajo, Niek F. van Hulst, de Bakker, Bärbel I., Vámosi, György, Erik M. H. P. van Dijk, Dijk, E. M. H. P. van, de Bakker, B.I., Bärbel I. de Bakker   +24 more
core   +1 more source

Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Frontiers in Immunology, 2021
Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type
Chunren Meng, Chunren Meng, Chufeng Gu, Chufeng Gu, Shuai He, Shuai He, Tong Su, Tong Su, Thashi Lhamo, Deji Draga, Qinghua Qiu, Qinghua Qiu, Qinghua Qiu   +12 more
doaj   +1 more source

Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2011
AbstractIntroductionThere has been no report in the literature of a soluble form of interleukin (IL)-18 receptor α (IL-18Rα). In this study, we evaluated the levels and characteristics of soluble IL-18Rα (sIL-18Rα) in the sera of patients with rheumatoid arthritis (RA) and compared these results to control populations.MethodsThe sIL-18Rα complex was ...
Takei, Satoko, Hoshino, Tomoaki, Matsunaga, Kazuko, Sakazaki, Yuki, Sawada, Masanori, Oda, Hanako, Takenaka, Shin-ichi, Imaoka, Haruki, Kinoshita, Takashi, Honda, Seiyo, Ida, Hiroaki, Fukuda, Taka-aki, Aizawa, Hisamichi   +12 more
openaire   +2 more sources