Results 11 to 20 of about 120,852 (299)

Cardiolipin and the Nlrp3 Inflammasome [PDF]

Cell Metabolism, 2013
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting ...
O\u27NEILL, LUKE
openaire   +4 more sources

Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA

International Journal of Nanomedicine, 2023
Jing Huang,1,* Mengmeng Dai,1,* Mingxia He,1,* Weicheng Bu,1 Liwen Cao,1 Jing Jing,1 Run Cao,1 Hailong Zhang,1 Ke Men2 1Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital, Henan University, Kaifeng, Henan ...
Huang J, Dai M, He M, Bu W, Cao L, Jing J, Cao R, Zhang H, Men K   +8 more
doaj   +1 more source

Inhibiting the NLRP3 Inflammasome [PDF]

Molecules, 2020
Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy, David Brough, Sally Freeman   +2 more
openaire   +4 more sources

NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation [PDF]

International Journal of Molecular Sciences, 2021
In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state of an inflammatory response.
Mahbuba Akther, Md Ezazul Haque, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee   +4 more
openaire   +2 more sources

CAPS and NLRP3 [PDF]

Journal of Clinical Immunology, 2019
Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory ...
Laela M. Booshehri, Hal M. Hoffman
openaire   +2 more sources

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress [PDF]

, 2023
NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and ...
Mélanie Bodnar-Wachtel, Annabelle Ballesta, Janet Hall, Hall, Janet, Guey, Baptiste, Sylvie Lantuejoul, François Ghiringhelli, Truntzer, Caroline, Couté, Yohann, Elise Ballot, Huber, Anne-Laure, Lantuejoul, Sylvie, Baptiste Guey, Lecuelle, Julie, Sabine Hacot, Ghiringhelli, François, Anne-Laure Huber, Bodnar-Wachtel, Mélanie, Agnès Tissier, Delphine Burlet, Caroline Truntzer, Bénédicte F Py, Gérossier, Laetitia, Goutagny, Nadège, Laetitia Gérossier, Birke Bartosch, Bartosch, Birke, Julie Lecuelle, Burlet, Delphine, Virginie Petrilli, Ballot, Elise, Yohann Couté, Hacot, Sabine, Gorry, Julie, Nadège Goutagny, Py, Bénédicte F, Ballesta, Annabelle, Tissier, Agnès, Py, Bénédicte, F, Petrilli, Virginie, Julie Gorry   +40 more
core   +1 more source

The double sides of NLRP3 inflammasome activation in sepsis

, 2023
International audienceAbstract Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic.
Py, Bénédicte F., Vigneron, Clara, Venet, Fabienne, Monneret, Guillaume, Clara Vigneron, Bénédicte F. Py, Fabienne Venet, Guillaume Monneret   +7 more
core   +1 more source

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
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NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

, 2021
International audienceAbstract NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC ...
Visvikis, Orane, Ricci, Roméo, Py, Bénédicte, Rey, Amaury, Lagrange, Brice, Niu, Tingting, Wong, Jeimin, Groslambert, Marine, Walker, Olivier, Wang, Ping, Chautard, Séverine, Henry, Thomas, Zhang, Zhirong, de Rosny, Charlotte, Patoli, Danish, Hologne, Maggy, Cosson, Camille, Hacot, Sabine, Petrilli, Virginie, Boyer, Laurent, Py, Bénedicte F., De Rosny, C. (Charlotte), Chautard, S. (Séverine), Patoli, D. (Danish), Séverine Chautard, Niu, T. (Tingting), Sabine Hacot, Ricci, R. (Romeo), Cosson, C. (Camille), Boyer, L. (Laurent), Ping Wang, Visvikis, O. (Oriane), Bénédicte F. Py, Hacot, S. (Sabine), Amaury Rey, Jeimin Wong, Charlotte De Rosny, Marine Groslambert, Groslambert, M. (Marine), Henry, T. (Thomas), Camille Cosson, Petrilli, V. (Virginie), Tingting Niu, Laurent Boyer, Rey, A. (Amaury), Danish Patoli, Walker, O. (Olivier), Thomas Henry, Zhang, Z. (Zhirong), Brice Lagrange, Roméo Ricci, Olivier Walker, Wang, P. (Ping), Orane Visvikis, Maggy Hologne, Virginie Petrilli, Zhirong Zhang, Wong, J. (Jeimin), Hologne, M. (Maggy)   +58 more
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Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Schnurr, M., Bauer, Christian, Düwell, Peter, Endres, S., Bauer, C., Duewell, P., Schnurr, Max, Lehr, Hans-Anton, Lehr, H.A., Endres, Stefan   +9 more
core   +1 more source