Results 11 to 20 of about 113,850 (298)

The double sides of NLRP3 inflammasome activation in sepsis

, 2023
International audienceAbstract Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic.
Py, Bénédicte F., Vigneron, Clara, Venet, Fabienne, Monneret, Guillaume   +3 more
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Serum NLRP3 and S1P as Potential Diagnostic and Prognostic Biomarkers in Female Metastatic and Non-Metastatic Breast Cancer Patients

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Background: Breast cancer (BC) is considered the main cause of death in women worldwide. Overexpression of Sphingosine 1-phosphate (S1P) receptors in estrogen receptor (ER) negative BC patients is linked to poor prognosis.
Anas R. Soltan , Amany M. Kamal, Reham A. A. El-Shimy , Hala O. El-Mesallamy   +3 more
doaj   +1 more source

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]

, 2012
Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe, Meunier, Etienne, Bernard Pipy, David Olagnier, José Bernad, Agnès Coste, Authier, Hélène, Emmanuel Flahaut, Béraud, Maryse, Bernad, José, Flahaut, Emmanuel, Etienne Meunier, Maryse Béraud, Pipy, Bernard, Lise Lefèvre, Christophe Dardenne, Coste, Agnès, Hélène Authier, Olagnier, David, Lefèvre, Lise   +19 more
core   +1 more source

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
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Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Schnurr, M., Bauer, Christian, Düwell, Peter, Endres, S., Bauer, C., Duewell, P., Schnurr, Max, Lehr, Hans-Anton, Lehr, H.A., Endres, Stefan   +9 more
core   +1 more source

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

, 2021
International audienceAbstract NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC ...
Visvikis, Orane, Ricci, Roméo, Py, Bénédicte, Rey, Amaury, Lagrange, Brice, Niu, Tingting, Wong, Jeimin, Groslambert, Marine, Walker, Olivier, Wang, Ping, Chautard, Séverine, Henry, Thomas, Zhang, Zhirong, de Rosny, Charlotte, Patoli, Danish, Hologne, Maggy, Cosson, Camille, Hacot, Sabine, Petrilli, Virginie, Boyer, Laurent   +19 more
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Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

Journal of Inflammation Research, 2021
Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National ...
Ji N, Qi Z, Wang Y, Yang X, Yan Z, Li M, Ge Q, Zhang J   +7 more
doaj  

Diabetes Mellitus Promotes Atrial Structural Remodeling and PARP-1/Ikkα/NF-κB Pathway Activation in Mice

Diabetes, Metabolic Syndrome and Obesity, 2021
Tianyu Meng,1,* Jie Wang,2,3,* Manyun Tang,2 Shangyu Liu,4 Ligang Ding,4 Yang Yan5 1Department of Geriatrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Department of
Meng T, Wang J, Tang M, Liu S, Ding L, Yan Y   +5 more
doaj  

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

Inflammasome as an Effective Platform for Fibrosis Therapy

Journal of Inflammation Research, 2021
Ting-Ting Chen,* Feng Xiao,* Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui
Chen TT, Xiao F, Li N, Shan S, Qi M, Wang ZY, Zhang SN, Wei W, Sun WY   +8 more
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