World Journal of Traditional Chinese MedicineObjective: Disturbance of gut microbiota plays an essential role in metabolic diseases, such as diabetes. Jiedutongluotiaogan formula (JTTF) was designed to meliorate the symptoms of type 2 diabetes.
Jin-Li Luo +9 more
doaj +2 more sources
Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Few studies have investigated the mechanism by which exercise training promotes neural repair during rehabilitation after stroke. In this study, we evaluated the neuroprotective effects of exercise training and pyroptosis-associated factors
Fang Luo +5 more
doaj +1 more source
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway [PDF]
Frontiers in Aging Neuroscience, 2021 A classical hallmark of Parkinson’s disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites, although its role in microglial dysfunction and resultant dopaminergic (DAergic) neurotoxicity is still elusive.
Manikandan Samidurai +10 more
openaire +3 more sources
Protective effect of Guanxin Danshen formula on myocardial ischemiareperfusion injury in rats
Acta Cirúrgica Brasileira, 2023 Purpose: Myocardial ischemia/reperfusion injury (MIRI) leads to myocardial tissue necrosis, which will increase the size of myocardial infarction. The study examined the protective effect and mechanism of the Guanxin Danshen formula (GXDSF) on MIRI in ...
Lanfang Li +4 more
doaj +1 more source
Acta Cirúrgica Brasileira, 2022 Purpose: Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting ...
Dan Li +4 more
doaj +1 more source
Pharmaceutical Biology, 2022 Context Er Miao San (EMS) is a formulation that contains Atractylodis Rhizoma and Phellodendri Cortex in 1:1 ratio, and is commonly used to treat rheumatoid arthritis (RA) and other inflammatory diseases.Objective We investigated the mechanism of action ...
Min Liu +7 more
doaj +1 more source
Acta Cirúrgica Brasileira, 2022 Purpose: Abnormal activation of NOD-like receptor protein 3 (NLRP3) inflammasome can lead to the occurrence and progression of acute pancreatitis. This study investigated the protective effect of MCC950 on pancreatitis mice.
Yanghui Shen +4 more
doaj +1 more source
Puerarin protects renal ischemia-reperfusion injury in rats through NLRP3/Caspase-1/GSDMD pathway
Acta Cirúrgica Brasileira, 2023 Purpose: To observe the effect of puerarin on renal ischemia-reperfusion (I/R) injury in rats, and to explore its mechanism based on NLRP3/Caspase-1/GSDMD pathway.
Kangyu Wang +5 more
doaj +1 more source
Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation
Acta Cirúrgica Brasileira, 2022 Purpose: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. Methods: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group.
Yizhe Zhang +4 more
doaj +1 more source
Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis [PDF]
BioMed Research International, 2017 Uncoupling protein 2 (UCP2) may be critical for intestinal barrier function which may play a key role in the development of sepsis, and insulin has been reported to have anti-inflammatory effects. Male Sprague-Dawley rats were randomly allocated into five groups: control group, cecal ligation and puncture (CLP) group, sham surgery group, CLP plus ...
Jun-liang Zhang +5 more
openaire +2 more sources