Anti-NLRP3 Inflammasome Natural Compounds: An Update
Biomedicines, 2021 The nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex that recognizes various danger or stress signals from pathogens, the host, and the environment ...
Baolong Liu, Jiujiu Yu
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Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells
Toxins, 2023 Deoxynivalenol (DON) is known as a vomitoxin, which frequently contaminates feedstuffs, such as corn, wheat, and barley. Intake of DON-contaminated feed has been known to cause undesirable effects, including diarrhea, emesis, reduced feed intake ...
Tae Hong Kang +4 more
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The Role of NLRP3 Inflammasomes in Trained Immunity
Frontiers in Bioscience-Landmark, 2023 Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis.
Gilyoung Lee +3 more
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Journal of Neuroinflammation, 2021 The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent immune cell sensors.
Qingxue Xu +6 more
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Salmonella Enteritidis GalE Protein Inhibits LPS-Induced NLRP3 Inflammasome Activation
Microorganisms, 2022 Microbial infection can trigger the assembly of inflammasomes and promote secretion of cytokines, such as IL-1β and IL-18. It is well-known that Salmonella modulates the activation of NLRC4 (NLR family CARD domain-containing protein 4) and NLRP3 (NLR ...
Tingting Huang +6 more
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EXPRESSION OF BLOOD EXOSOMAL miR-223 AND NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-LIKE RECEPTOR PROTEIN 3 IN PATIENTS WITH ALZHEIMER’S DISEASE AND THEIR CLINICAL SIGNIFICANCE [PDF]
精准医学杂志, 2023 Objective To investigate the expression levels of serum exosomal miR-223 and nucleotide-binding oligome-rization domain-like receptor protein 3 (NLRP3) in patients with Alzheimer’s disease (AD) and their association with the development and progression ...
SHI Junliang, HAO Yuping, XIA Yuan, DAI Enyun
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PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB–p65/NLRP3 pathway [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Asthma is a complex inflammatory disease of the lungs marked by increased infiltration of leukocytes into the airways, which restricts respiratory function.
Rui Fang +4 more
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NLRP3: Role in ischemia/reperfusion injuries
Frontiers in Immunology, 2022 NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome.
Soudeh Ghafouri-Fard +10 more
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Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice
Mediators of Inflammation, 2013 Alcoholic liver disease (ALD) is characterized by increased hepatic lipid accumulation (steatosis) and inflammation with increased expression of proinflammatory cytokines.
David A. DeSantis +6 more
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Effect of diosmetin on rats with liver fibrosis and its mechanism [PDF]
精准医学杂志Objective To investigate the effect of diosmetin on rats with liver fibrosis and its mechanism. Methods A total of 60 specific pathogen-free male Sprague-Dawley rats were randomly divided into groups A, B, C, D, E, and F, with 10 rats in each group.
TAN Lixia, HUA Jing, YAN Chunxiao, WANG Hangyu, DONG Yong, WEI Shutang
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