Results 41 to 50 of about 22,554 (186)

Domain architecture evolution of pattern-recognition receptors [PDF]

, 2010
In animals, the innate immune system is the first line of defense against invading microorganisms, and the pattern-recognition receptors (PRRs) are the key components of this system, detecting microbial invasion and initiating innate immune defenses. Two
Qing Zhang, Christian M. Zmasek, Adam Godzik, SF Altschul, G Apic, NA Baker, MK Basu, A Bateman, B Beutler, TA Binkowski, AK Bjorklund, D Boraschi, CB Burge, AA Canutescu, RR Copley, JA Darling, R Desper, M Dlugosz, CB Do, SR Eddy, J Felsenstein, K Forslund, JH Fritz, O Gascuel, J Gough, JH Han, T Hibino, AL Hughes, AL Hughes, A Ishii, Z Kambris, TD Kanneganti, K Katoh, KJ Laing, O Lespinet, F Leulier, A Marchler-Bauer, A Marchler-Bauer, F Martinon, AF McGettrick, R Medzhitov, PA Nuin, LA O'Neill, H Oshiumi, L Patthy, K Pawlowski, NH Putnam, NH Putnam, H Qin, AJ Robertson, F Ronquist, L Sael, N Saitou, JM Sasin, HA Schmidt, E Sodergren, A Stamatakis, C Stein, JP Ting, J Weiner 3rd, AP West, MJ West-Eberhard, Q Zhang   +62 more
core   +2 more sources

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish [PDF]

, 2008
Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa.
Kerry J Laing, Maureen K Purcell, James R Winton, John D Hansen   +3 more
core   +2 more sources

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]

, 2010
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S, Datta, Pinaki, Eisenlohr, Laurence, Fernandes-Alnemri, Teresa, Huang, Lan, Juliana, Christine, Kang, Seokwon, Landel, Carlisle P, McCormick, Margaret, McDermott, Erin, Solorzano, Leobaldo, Wu, Jianghong, Yu, Je-Wook   +12 more
core   +5 more sources

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition [PDF]

, 2019
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases ...
Demon, Dieter, Fossoul, Amelie, Kayagaki, Nobuhiko, Konvalinka, Jan, Kostka, Libor, Lamkanfi, Mohamed, Lee, Bettina L, Pham, Victoria C, Sacha, Pavel, Simon, Petr, Staben, Steven T, Stivala, Craig E, Stowe, Irma B, Subrt, Vladimir, Van Hauwermeiren, Filip, Vande Walle, Lieselotte, Viana Saavedra, Pedro Henrique, Yamazoe, Sayumi   +17 more
core   +1 more source

Identification of mutations in the PYRIN-containing NLR genes (NLRP) in head and neck squamous cell carcinoma [PDF]

, 2014
Head and Neck Squamous Cell Carcinoma (HNSCC) encompasses malignancies that arise in the mucosa of the upper aerodigestive tract. Recent high throughput DNA sequencing revealed HNSCC genes mutations that contribute to several cancer cell characteristics,
A Mashberg, Ann Marie Egloff, BK Davis, BW Neville, CB Moore, D Hanahan, E Elinav, E Meyer, E White, EA Collisson, GY Chen, HS van Monsjou, IC Allen, IC Allen, J Ahn, J Ferlay, Jennifer R. Grandis, JH Meurman, JP Ting, JP Ting, JP Ting, KK Ang, KV Woods, M Lamkanfi, MA O'Rorke, MH Zaki, MH Zaki, MH Zaki, MS Meyer, Muy-Teck Teh, N Agrawal, N Jounai, N Stransky, R Cooney, R Pries, R Slim, S Nik-Zainal, S Nik-Zainal, S Normand, T Strowig, V Brailo, Vivian W. Y. Lui, Y Lei, Y Lei, Yu Lei   +44 more
core   +5 more sources

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Journal of Neuroinflammation, 2021
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent immune cell sensors.
Qingxue Xu, Bo Zhao, Yingze Ye, Yina Li, Yonggang Zhang, Xiaoxing Xiong, Lijuan Gu   +6 more
doaj   +1 more source

Salmonella Enteritidis GalE Protein Inhibits LPS-Induced NLRP3 Inflammasome Activation

Microorganisms, 2022
Microbial infection can trigger the assembly of inflammasomes and promote secretion of cytokines, such as IL-1β and IL-18. It is well-known that Salmonella modulates the activation of NLRC4 (NLR family CARD domain-containing protein 4) and NLRP3 (NLR ...
Tingting Huang, Dan Gu, Yaxin Guo, Ang Li, Xilong Kang, Xinan Jiao, Zhiming Pan   +6 more
doaj   +1 more source

EXPRESSION OF BLOOD EXOSOMAL miR-223 AND NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-LIKE RECEPTOR PROTEIN 3 IN PATIENTS WITH ALZHEIMER’S DISEASE AND THEIR CLINICAL SIGNIFICANCE [PDF]

精准医学杂志, 2023
Objective To investigate the expression levels of serum exosomal miR-223 and nucleotide-binding oligome-rization domain-like receptor protein 3 (NLRP3) in patients with Alzheimer’s disease (AD) and their association with the development and progression ...
SHI Junliang, HAO Yuping, XIA Yuan, DAI Enyun
doaj   +1 more source