Results 41 to 50 of about 26,384,108 (210)

Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Mediators of Inflammation, 2013
Alcoholic liver disease (ALD) is characterized by increased hepatic lipid accumulation (steatosis) and inflammation with increased expression of proinflammatory cytokines.
David A. DeSantis, Chih-wei Ko, Yang Liu, Xiuli Liu, Amy G. Hise, Gabriel Nunez, Colleen M. Croniger   +6 more
doaj   +1 more source

Effect of diosmetin on rats with liver fibrosis and its mechanism [PDF]

精准医学杂志
Objective To investigate the effect of diosmetin on rats with liver fibrosis and its mechanism. Methods A total of 60 specific pathogen-free male Sprague-Dawley rats were randomly divided into groups A, B, C, D, E, and F, with 10 rats in each group.
TAN Lixia, HUA Jing, YAN Chunxiao, WANG Hangyu, DONG Yong, WEI Shutang
doaj   +1 more source

NLRP3: Role in ischemia/reperfusion injuries

Frontiers in Immunology, 2022
NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome.
Soudeh Ghafouri-Fard, Hamed Shoorei, Hamed Shoorei, Yadollah Poornajaf, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Yasaman Hajiesmaeili, Atefe Abak, Mohammad Taheri, Mohammad Taheri, Ahmad Eghbali   +10 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes

European Journal of Medical Research
Abstract Objective There is a growing body of evidence indicating that pyroptosis, a programmed cell death mechanism, plays a crucial role in the exacerbation of inflammation and fibrosis in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).
FengJuan Chen, YuFeng Xing, ZhiJie Chen, XiaoMan Chen, Jie Li, Si Gong, Fang Luo, QingXian Cai   +7 more
openaire   +3 more sources

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease

Biomedical Journal, 2023
Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ...
Sungji Cho, Fan Ying, Gary Sweeney
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Relationship between sepsis-associated encephalopathy and nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and progress of traditional Chinese medicine treatment

Chinese Journal of Contemporary Neurology and Neurosurgery
Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis leading to neurological dysfunction. The pathogenesis of sepsis-associated encephalopathy is complex, and studies have proved that it is closely related to neuroinflammation ...
CHEN Yue, LIU Xue-hua
doaj   +1 more source

Reconstruction of the Mouse Inflammasome System in HEK293T Cells

Bio-Protocol, 2016
The NLRP3 (NLR family, Pyrin domain containing 3) inflammasome is a multiprotein complex comprised of NLRP3, pro-caspase-1, the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and the protein kinase NIMA related kinase 7 (
Hexin Shi, Anne Murray , Bruce Beutler
doaj   +1 more source