Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90366/1/j.1365-2249.2011.04535.x ...
Franchi, Luigi, Ozkurede, V. U.
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Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. [PDF]
, 2015 Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis.
Bryant, Clare E, Monie, Tom P
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PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB–p65/NLRP3 pathway [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Asthma is a complex inflammatory disease of the lungs marked by increased infiltration of leukocytes into the airways, which restricts respiratory function.
Rui Fang +4 more
doaj +1 more source
NLRP3: Role in ischemia/reperfusion injuries
Frontiers in Immunology, 2022 NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome.
Soudeh Ghafouri-Fard +10 more
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Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
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Insights into assembly of the macromolecular inflammasome complex [PDF]
, 2014 This is the published version. It first appeared at http://www.degruyter.com/view/j/infl.2013.1.issue-1/infl-2014-0009/infl-2014-0009.xml.AbstractDramatic advances in our understanding of the ultrastructure of the inflammasome and the molecular ...
Boyle, Joseph P, Monie, Tom P
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Effect of diosmetin on rats with liver fibrosis and its mechanism [PDF]
精准医学杂志Objective To investigate the effect of diosmetin on rats with liver fibrosis and its mechanism. Methods A total of 60 specific pathogen-free male Sprague-Dawley rats were randomly divided into groups A, B, C, D, E, and F, with 10 rats in each group.
TAN Lixia, HUA Jing, YAN Chunxiao, WANG Hangyu, DONG Yong, WEI Shutang
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Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice
Mediators of Inflammation, 2013 Alcoholic liver disease (ALD) is characterized by increased hepatic lipid accumulation (steatosis) and inflammation with increased expression of proinflammatory cytokines.
David A. DeSantis +6 more
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C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways [PDF]
, 2013 Peer reviewedPublisher ...
Brown, Gordon D +2 more
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Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease
Biomedical Journal, 2023 Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ...
Sungji Cho, Fan Ying, Gary Sweeney
doaj +1 more source