Results 71 to 80 of about 22,554 (186)

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Relationship between sepsis-associated encephalopathy and nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and progress of traditional Chinese medicine treatment

Chinese Journal of Contemporary Neurology and Neurosurgery
Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis leading to neurological dysfunction. The pathogenesis of sepsis-associated encephalopathy is complex, and studies have proved that it is closely related to neuroinflammation ...
CHEN Yue, LIU Xue-hua
doaj   +1 more source

The Cag pathogenicity island and interaction between TLR 2/ NOD 2 and NLRP 3 regulate IL ‐1β production in Helicobacter pylori infected dendritic cells [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100315/1/eji2723 ...
Backert, Steffen, Franchi, Luigi, Kim, Dong‐jae, Núñez, Gabriel, Park, Jong‐hwan   +4 more
core   +1 more source

Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102624/1/eji2871 ...
Couturier‐Maillard A., Couturier‐Maillard A., Inohara N.   +2 more
core   +1 more source

The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice

Dose-Response, 2020
With the extensive application of radiotherapy in various cancers, its side effects in tissues adjacent to cancers are garnering much attention. Intestines are sensitive to irradiation due to its rapid proliferation, and irradiation-induced enteric ...
Hao Sun, Hui Cai, Yue Fu, Qin Wang, Kaihua Ji, Liqing Du, Chang Xu, Lifang Tian, Ningning He, Jinhan Wang, Manman Zhang, Yang Liu, Yan Wang, Jia Li, Qiang Liu   +14 more
doaj   +1 more source

Is the inflammasome a potential therapeutic target in renal disease? [PDF]

, 2014
The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These
A Chen, A Covic, A Dorfleutner, A Fukami, A Granfeldt, A MacKenzie, A So, A Vilaysane, AA Shigeoka, AH Bani-Hani, AJ Puren, AM Karkar, AM Karkar, AN Economides, AS Yazdi, BA VanderBrink, BJ Pereira, C Dostert, C Hammerberg, CA Dinarello, CA Dinarello, CA Dinarello, CA Dinarello, CJ Chen, CL Edelstein, CL Myers, Clare M Turner, CM Turner, CM Turner, CM Yang, CR Parikh, D Choubey, D Ferrari, D Ferrari, D Nordstrom, D Sola-Villa, DG Perregaux, E Homsi, EA Kurt-Jones, EA Miao, EC Keystone, ED Siew, EM Kofoed, F Bauernfeind, F Knauf, F Turkmen, FG Bauernfeind, Frederick WK Tam, FW Tam, FW Tam, G Dell’Antonio, G Dell’Antonio, G Kaplanski, G Nuki, G Ren, GY Chen, H Harada, H Kohka, H Ranjbaran, H Saiga, H von Bernuth, H Wu, H Yamagishi, H Zhang, HJ Lachmann, HM Hoffman, HU Schorlemmer, HY Lan, I Jalilian, IC Allen, J Lichtnekert, J Wang, JC Morel, JL Levinsohn, JM Bruey, JM Kahlenberg, JR Timoshanko, K Furuichi, K Kersse, K Kinoshita, K Matsumoto, K Rusai, K Takeda, K Wareham, KL Williams, KM Sumpter, LK Parvathenani, M Hacham, M Haq, M Lech, M Mizobuchi, M Shiohara, M Sugiyama, M Takeuchi, M Tomura, MD Wewers, Mervyn Singer, MP Bevilacqua, N Arulkumaran, N Arulkumaran, N Kolliputi, N Ueno, NA Thornberry, NB Bryan, NB Bryan, Nishkantha Arulkumaran, O Gross, O Hertting, O Vonend, R Alten, R Goldbach-Mansky, R Imamura, RG Goncalves, Robert J Unwin, S Cornelis, S Deplano, S Gangemi, S Gauer, SC Whitman, SL Fernando, SL Fink, SR Ali, SR Mulay, SR Taylor, SR Taylor, SS Iyer, T Bergsbaken, T Bergsbaken, T Dao, T Fujita, T Porazko, TL Roberts, U Kavita, V Hurgin, V Pascual, W Wang, X Wang, Y Chung, Y le Meur, Y Liu, Y Zhao, Z Mallat, Z Ye   +142 more
core   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Frontiers in Immunology, 2021
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4
Patrick Münzer, Patrick Münzer, Patrick Münzer, Patrick Münzer, Roberto Negro, Roberto Negro, Shoichi Fukui, Shoichi Fukui, Lucas di Meglio, Lucas di Meglio, Lucas di Meglio, Karen Aymonnier, Karen Aymonnier, Karen Aymonnier, Long Chu, Long Chu, Deya Cherpokova, Deya Cherpokova, Sarah Gutch, Sarah Gutch, Nicoletta Sorvillo, Nicoletta Sorvillo, Lai Shi, Lai Shi, Venkat Giri Magupalli, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Rüdiger E. Scharf, Rüdiger E. Scharf, Clare M. Waterman, Clare M. Waterman, Hao Wu, Hao Wu, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner, Denisa D. Wagner   +37 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source