Results 81 to 90 of about 22,554 (186)

Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion

Frontiers in Immunology, 2017
Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating apoptotic bodies is not cleared, leading to anti-DNA antibody production.
Guilan Shi, Kennady N. Abbott, Wenbo Wu, Russell D. Salter, Peter A. Keyel, Peter A. Keyel   +5 more
doaj   +1 more source

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking

Pharmaceuticals, 2022
Dehydroisohispanolone (DIH), is a labdane diterpene that has exhibited anti-inflammatory activity via inhibition of NF-κB activation, although its potential effects on inflammasome activation remain unexplored.
Laura González-Cofrade, Irene Cuadrado, Ángel Amesty, Ana Estévez-Braun, Beatriz de las Heras, Sonsoles Hortelano   +5 more
doaj   +1 more source

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens [PDF]

, 2012
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune responses through activation of nuclear factor-kappa B (NF-kappa B), type I interferon and inflammasome signalling(1).
C van Ooij, DA Portnoy, E Elinav, E Scallan, EM Creagh, GY Chen, J Henao-Mejia, JM Grenier, John Bertin, John R. Lukens, K Hybiske, K Meixenberger, KS Kobayashi, L Franchi, M Lara-Tejero, MH Zaki, MM Stevenson, Mohamed Lamkanfi, MR Waterfield, NV Serbina, P Broz, Paras K. Anand, Peter Vogel, PK Anand, R. K. Subbarao Malireddi, S Normand, SC Corr, SE Girardin, TD Kanneganti, TD Kanneganti, Thirumala-Devi Kanneganti, V Pétrilli   +31 more
core   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss

Neural Regeneration Research, 2022
The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune system. It plays a crucial role in the pathological process of noise-induced hearing loss (NIHL).
Na Sai, Yuan-Yuan Yang, Long Ma, Da Liu, Qing-Qing Jiang, Wei-Wei Guo, Wei-Ju Han   +6 more
doaj   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, EarlyView.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Suppression of ZBP1-mediated NLRP3 inflammasome by the tegument protein VP22 facilitates pseudorabies virus infection

mBio
The interaction between Z-DNA binding protein 1 (ZBP1) and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been uncovered in several viral infections.
Zicheng Ma, Depeng Liu, Wandi Cao, Lei Guo, Kesen Liu, Juan Bai, Xingyi Li, Ping Jiang, Xing Liu   +8 more
doaj   +1 more source

CD90+ Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa [PDF]

, 2013
Immune responses at the intestinal mucosa must allow for host protection whilst simultaneously avoiding inappropriate inflammation. Although much work has focused on the innate immune functionality of hematopoietic immune cells, non-hematopoietic cell ...
Alice eMayer, Alison eSimmons, Alison eSimmons, Benjamin M J Owens, David eWalcott, Mei-Yi eSun, Michael eDudek, Philip eAllan, Tessa A M Steevels   +8 more
core   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Molecular mechanisms of AMPK/YAP/NLRP3 signaling pathway affecting the occurrence and development of ankylosing spondylitis

Journal of Orthopaedic Surgery and Research, 2023
Background Investigate the AMPK (protein kinase AMP-activated catalytic subunit alpha 1)/YAP (Yes1 associated transcriptional regulator)/NLRP3 (NLR family pyrin domain containing 3) signaling pathway's role in ankylosing spondylitis (AS) development ...
Ruiyang Fu, Xiaoqing Guo, Zhongqiang Pan, Yaling Wang, Jing Xu, Lei Zhang, Jinxia Li   +6 more
doaj   +1 more source