Results 101 to 110 of about 26,384,108 (210)

DHA Ameliorates Alzheimer’s Disease by Attenuating Microglial Pyroptosis via Regulation of the HOXA9-NLRP3 Pathway

Frontiers in Bioscience-Landmark
Background: Alzheimer’s disease (AD) involves a progressive deterioration of cognitive abilities, memory loss, and persistent brain inflammation.
Jia-Li Xie, Xiao-Hui Hu, Chun-Ling Wu, Qi Jin, Jian-Ping Pan   +4 more
doaj   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome

, 2017
Background: Cryopyrin-associated periodic syndrome (CAPS) is a group of rare, heterogeneous autoinflammatory disease characterized by interleukin (IL)-1β-mediated systemic inflammation and clinical symptoms involving skin, joints, central nervous system,
Jian-Zhong Zhang, Jian Hu, Zhang, Jian-Zhong, Zhu, Yun, Hu, Jian, Yun Zhu, Zhang, Rong-Guang, Rong-Guang Zhang, Li, Hou-Min, Hou-Min Li   +9 more
core   +1 more source

Calcium binding activity of the epidermal growth factor-like domains of the apicomplexan microneme protein EtMIC4 [PDF]

, 2005
Microneme proteins are secreted from apicomplexan parasites during invasion of host cells and they play crucial roles in parasite-host cell adhesion.
Gill, A C, Knott, V, Tomley, F M, Periz, J, Tomley, FM, Handford, P A, Gill, AC, Handford, Penelope, Handford, PA   +8 more
core   +1 more source

Sirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification

Molecular Biomedicine
Chronic kidney disease (CKD) markedly accelerates calcific aortic valve disease (CAVD), yet the underlying mechanisms and therapeutic targets remain poorly defined.
Li Xu, Yidan Zheng, Ming Liu, Bowen Deng, Xingyu Qian, Chen Jiang, Yuqi Liu, Pengning Fan, Zhenqi Rao, Ming Chen, Zhe Chen, Zhejun Cai, Nianguo Dong, Da Zhu, Fei Li   +14 more
doaj   +1 more source

USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis

Frontiers in Immunology
Duodenogastric reflux (DGR) has been linked to the onset of gastric cancer (GC), although the precise mechanism is yet obscure. Herein, we aimed to investigate how refluxed bile acids (BAs) and macrophages are involved in gastric carcinogenesis.
Chenye Zhao, Mingchao Mu, Xiaopeng Li, Zepeng Dong, Jiahao Wang, Chengzhi Yao, Jianbao Zheng, Xuejun Sun, Junhui Yu   +8 more
doaj   +1 more source

Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1076-1089, September 2026.
This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley   +1 more source

Identification of mutations in the PYRIN-containing NLR genes (NLRP) in head and neck squamous cell carcinoma [PDF]

, 2014
Head and Neck Squamous Cell Carcinoma (HNSCC) encompasses malignancies that arise in the mucosa of the upper aerodigestive tract. Recent high throughput DNA sequencing revealed HNSCC genes mutations that contribute to several cancer cell characteristics,
Egloff, Ann Marie, Egloff, AM, Jennifer R. Grandis (505756), Lei Yu, Egloff Ann Marie, Grandis, JR, Jennifer R Grandis, Ann Marie Egloff (511298), Yu Lei (266919), Lei, Yu, Lui, Vivian W. Y., Yu Lei, Grandis Jennifer R., Grandis, Jennifer R., Grandis, Jennifer, Lei, Y, Vivian W Y Lui, Vivian W. Y. Lui (511297), Lui, VWY, Ann Marie Egloff, Lui Vivian W. Y.   +20 more
core   +2 more sources

Medicarpin Mediates the Protective Effect of Cell Pyroptosis Against Sepsis‐Induced Liver Injury by NLRP3/GSDMD/Caspase‐1 Axis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Med reduces pyroptosis in LPS‐induced THLE‐2 cells by inactivating NLRP3/GSDMD/caspase‐1, thereby exerting a protective effect in sepsis‐induced liver injury. ABSTRACT The liver is a decisive organ that is damaged by sepsis. Medicarpin (Med) is a principal wing‐type final product of 5‐deoxyisoflavone sub‐branch in M.
Pengfei Chen, Weifeng Jiang
wiley   +1 more source