Results 101 to 110 of about 22,554 (186)

Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. [PDF]

, 2015
PFAPA syndrome is the most common autoinflammatory syndrome in children from Western countries. In spite of its strong familial clustering, its genetic basis and inheritance pattern are still unknown.
Bedoni, N., Gioia, S.A., Hofer, M., Rivolta, C., Superti-Furga, A., Vanoni, F., von Scheven-Gête, A.   +6 more
core   +3 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, Volume 13, Issue 20, 9 April 2026.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Acupuncture: A Promising Non‐Pharmacological Approach to Parkinson's Disease Management

Brain and Behavior, Volume 16, Issue 4, April 2026.
The mechanism of acupuncture treatment of PD models involves oxidative stress, intestinal flora, neuroinflammation, autophagy, neurogenesis, pyroptosis, and apoptosis. ABSTRACT Purpose This review aims to elucidate the molecular mechanisms underlying the neuroprotective effects of acupuncture in preclinical models of Parkinson's disease (PD).
Xi‐Chen Wu, Yi‐Yue Dong, Yu‐Chen Ying, Ping Yin, Yue‐Lai Chen   +4 more
wiley   +1 more source

Structure and evolutionary history of a large family of NLR proteins in the zebrafish [PDF]

, 2016
Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Howe, K, Kondrashov, F, Laird, GK, Leptin, M, Marioni, JC, Schiffer, PH, Soylemez, O, Wiehe, T, Zielinski, J   +8 more
core  

A molecular model of the full-length human NOD-like receptor family CARD domain containing 5 (NLRC5) protein [PDF]

, 2013
BACKGROUND: Pattern recognition receptors of the immune system have key roles in the regulation of pathways after the recognition of microbial- and danger-associated molecular patterns in vertebrates.
Bagossi, Péter, Benkő, Szilvia, Mótyán, János, Tőzsér, József   +3 more
core   +1 more source

Additional file 2 of Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes

Additional file 2. The sequences of siRNAs and the map of the pcDNA3.1 vector.
Chen, FengJuan, Xing, YuFeng, Chen, ZhiJie, Chen, XiaoMan, Li, Jie, Gong, Si, Luo, Fang, Cai, QingXian   +7 more
openaire   +1 more source

Pattern recognition receptors in antifungal immunity [PDF]

, 2014
We thank the Wellcome Trust for funding this study.Peer reviewedPublisher ...
Brown, Gordon D, Hardison, Sarah E, Plato, Anthony   +2 more
core   +2 more sources

DHA Ameliorates Alzheimer’s Disease by Attenuating Microglial Pyroptosis via Regulation of the HOXA9-NLRP3 Pathway

Frontiers in Bioscience-Landmark
Background: Alzheimer’s disease (AD) involves a progressive deterioration of cognitive abilities, memory loss, and persistent brain inflammation.
Jia-Li Xie, Xiao-Hui Hu, Chun-Ling Wu, Qi Jin, Jian-Ping Pan   +4 more
doaj   +1 more source

Biglycan : a multivalent proteoglycan providing structure and signals [PDF]

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Năstase, Mădălina-Viviana, Schäfer, Liliana, Young, Marian F.   +2 more
core  

USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis

Frontiers in Immunology
Duodenogastric reflux (DGR) has been linked to the onset of gastric cancer (GC), although the precise mechanism is yet obscure. Herein, we aimed to investigate how refluxed bile acids (BAs) and macrophages are involved in gastric carcinogenesis.
Chenye Zhao, Mingchao Mu, Xiaopeng Li, Zepeng Dong, Jiahao Wang, Chengzhi Yao, Jianbao Zheng, Xuejun Sun, Junhui Yu   +8 more
doaj   +1 more source