Results 121 to 130 of about 26,384,108 (210)

Multifaceted Immune Effects of the Scavenger Receptor CD36 on Long‐Term Outcomes After Neonatal Arterial Focal Stroke

open access: yesJournal of Neurochemistry, Volume 170, Issue 9, September 2026.
In neonatal mice, both stroke and direct TLR2 stimulation elicit pronounced but partially distinct CD36‐dependent gene expression profiles in the choroid plexus. CD36 mediates leukocyte trafficking through the choroid plexus and immune cell presence in the brain parenchyma after direct TLR2 stimulation and stroke in a context‐dependent manner.
Elena Di Martino   +7 more
wiley   +1 more source

The role of inflammasome dysregulation in obstructive and non-obstructive azoospermia: a comparative molecular analysis of blood, tissue, and seminal plasma

open access: yesFrontiers in Immunology
BackgroundTo address knowledge gaps, this study aimed to investigate the involvement of inflammasomes in the etiology of azoospermia. This study focused on the gene expression of key inflammasome components, including NLR family pyrin domain containing 3
Seyyed AmirHossein Mirghanizadeh Bafghi   +8 more
doaj   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective

open access: yesLiver International, Volume 46, Issue 9, September 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga   +4 more
wiley   +1 more source

Structure, function and subcellular localization of the potato Resistance protein Rx1 [PDF]

open access: yes, 2009
Resistance proteins are part of the plant’s immune system and mediate a defence response upon recognizing their cognate pathogens. They are thought to be present in the cell as part of a larger protein complex.
Slootweg, E.J.
core  

Overview of NLR family members according to their domain organization.

open access: yes, 2013
Protein name and synonyms (new synonyms in bold), accession number, and chromosomal location according to http://www.genenames.org/genefamily/nlr.php followed by domains as defined by FFAS.
Jörg H. Fritz (45565)   +4 more
core   +1 more source

Biological Therapies for Urate Lowering and Inflammation Control in Gout Management

open access: yesJournal of Inflammation Research
Ye Zhou,1,* Hengyan Zhang,2,* Nian Liu,1,3,* Heguo Yan,1 Fanyu Meng,1 Jiangyun Peng1,3 1First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 2Department of Rheumatology ...
Zhou Y   +5 more
doaj  

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

open access: yesFrontiers in Cell and Developmental Biology
High mobility group box-1 (HMGB1) is a protein released from stressed or damaged cells that triggers immune activation and chronic inflammation.
Lei Yang   +4 more
doaj   +1 more source

RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells

open access: yesScientific Reports
Gastric cancer (GC) is one of the most common malignancies worldwide, and its development is closely associated with the abnormal expression of numerous genes. RNA - binding protein with multiple splicing 2 (RBPMS2), a member of the RNA - binding protein
Nailin Zhang   +6 more
doaj   +1 more source

The effect of cortex eucommiae on alleviating lung injury induced by Haemophilus paragallinarum

open access: yesPoultry Science
To analyze whether Cortex Eucommiae (CE) can inhibit pathological lung injury by regulating autophagy levels in chicks lung tissue and identify potential targets, thereby alleviating pneumonia damage caused by Haemophilus paragallinarum (Hp) infection ...
Bo Zhang   +8 more
doaj   +1 more source

New insights into the structure domain and function of NLR family CARD domain containing 5

open access: yes
NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central ...
Yunxia Cao   +8 more
core   +1 more source

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