Results 121 to 130 of about 18,494 (150)

Cannabidiol Protects Against 1-Methyl-4-Phenylpyridinium and Manganese-Induced Neurotoxicity via Nod-Like Receptor Protein 3 Inflammasome Suppression. [PDF]

J Biochem Mol Toxicol
Demirel G, Yirün A, Çakir DA, Özkan H, Güneş BŞ, Selvi S, Öztürk YE, Erkekoğlu P.   +7 more
europepmc   +1 more source

A flavonoid extract from Bupleurum aerial parts given at recovery onset attenuates residual liver and lung injury in yellow-feathered broilers after acute heat exposure. [PDF]

Poult Sci
Wang Z, Li Z, Du Y, Li K.
europepmc   +1 more source

The NLRP3 Inflammasome: A Central Mediator in Sevoflurane-Induced Neurotoxicity and A Potential Target for Neuroprotection. [PDF]

Mol Neurobiol
Li N, Chen Y, Chen G.
europepmc   +1 more source

Biomaterial-based strategies targeting ferroptosis for alleviating intervertebral disc degeneration: Advances and perspectives. [PDF]

J Orthop Translat
Fu Y, Wang Z, Wang W, Xie Y, Chen L, Tan L, Liu M.   +6 more
europepmc   +1 more source

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The Inflammasome NLR Family Pyrin Domain-Containing Protein 3 (NLRP3) as a Novel Therapeutic Target for Idiopathic Pulmonary Fibrosis

The American Journal of Pathology, 2022
Idiopathic pulmonary fibrosis (IPF) is a dramatic disease without cure. The US Food and Drug Administration-approved drugs, pirfenidone and nintedanib, only slow disease progression. The clinical investigation of novel therapeutic approaches for IPF is an unmet clinical need. Nucleotide-binding oligomerization domain-like receptor or NOD-like receptors
Ruben M.L. Colunga Biancatelli, Pavel A. Solopov, John D. Catravas   +2 more
openaire   +2 more sources

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2020
Aberrant activation of NLRP3 inflammasome is present in a subset of acute and chronic inflammatory diseases. The NLRP3 inflammasome has been recognized as an attractive therapeutic target for developing novel and specific anti-inflammatory inhibitors. Cellular structure-activity relationship-guided optimization resulted in the identification of 4-oxo-2-
Yun, Chen, Hongbin, He, Hua, Jiang, Li, Li, Zhiyu, Hu, Huiying, Huang, Qingyan, Xu, Rongbin, Zhou, Xianming, Deng   +8 more
openaire   +2 more sources

Low Potassium Triggers Tubular Epithelial NLR Family Pyrin Domain-Containing 3/Apoptosis-Associated Speck-Like Protein-Containing a CARD–Driven Kidney Inflammation Independently of Inflammasomes

The American Journal of Pathology
Pathologic potassium (K+) deficiency causes kidney inflammation and injury, known as hypokalemic nephropathy (HN), the underlying pathogenesis of which is obscure. NLR family pyrin domain-containing 3 (NLRP3) inflammasomes are platforms that sense the reduction of intracellular K+, engaging inflammation and tissue injury. The present study investigated
Satoko Komori, Takanori Komada, Takayoshi Matsumura, Tadayoshi Karasawa, Yutaka Miura, Chintogtokh Baatarjav, Yoshitaka Gunji, Hidetoshi Aizawa, Yoshiko Mizushina, Noriyoshi Fukushima, Toru Sugihara, Satoshi Ando, Tetsuya Fujimura, Daisuke Nagata, Masafumi Takahashi   +14 more
openaire   +2 more sources

Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis

Bioengineered, 2021
Haosheng Zhang, Xiaoqing Shi, Zhengquan Huang   +2 more
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