The NLR family of innate immune and cell death sensors. [PDF]
ImmunityNucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition receptors that detect a wide variety of pathogenic and sterile triggers ...
Sundaram B +3 more
europepmc +6 more sources
Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome [PDF]
Frontiers in Immunology, 2018 The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj +6 more sources
Fine dissection of limber pine resistance to Cronartium ribicola using targeted sequencing of the NLR family [PDF]
BMC Genomics, 2021 Background Proteins with nucleotide binding site (NBS) and leucine-rich repeat (LRR) domains (NLR) make up one of most important resistance (R) families for plants to resist attacks from various pathogens and pests. The available transcriptomes of limber
Jun-Jun Liu +5 more
doaj +3 more sources
Genetic Variations of NLR family genes in Behcet's Disease. [PDF]
Sci Rep, 2016 This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of five NLR family genes (NOD1, NOD2, NLRP1, NLRP3 and CIITA) are associated with Behcet’s disease (BD) in a Chinese Han population.
Li L +6 more
europepmc +5 more sources
Structure and evolutionary history of a large family of NLR proteins in the zebrafish [PDF]
Open Biology, 2016 Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Kerstin Howe +8 more
doaj +8 more sources
The Nod-like receptor (NLR) family: a tale of similarities and differences. [PDF]
PLoS ONE, 2008 Innate immunity represents an important system with a variety of vital processes at the core of many diseases. In recent years, the central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses ...
Martina Proell +4 more
doaj +6 more sources
New insights into the structure domain and function of NLR family CARD domain containing 5. [PDF]
Cell Commun SignalNOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central ...
Zhu H +8 more
europepmc +5 more sources
Corrigendum: Genetic Variations of NLR family genes in Behcet's Disease. [PDF]
Sci Rep, 2016 Scientific Reports 6: Article number: 20098; published online: 01 February 2016; updated: 31 May 2016 This Article contains errors. In Table 1, the number of Female ‘186’ and Male ‘764’ patients enrolled in this study is incorrectly given as ‘950’ and ...
Li L +6 more
europepmc +6 more sources
Genome-wide identification of the NLR gene family in Haynaldia villosa by SMRT-RenSeq [PDF]
BMC Genomics, 2022 Background Nucleotide-binding and leucine-rich repeat (NLR) genes have attracted wide attention due to their crucial role in protecting plants from pathogens.
Zhenpu Huang +11 more
doaj +5 more sources
Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf. [PDF]
PLoS One, 2015 IMP/GMP preferring cytosolic 5'-nucleotidase II (cN-II) is a bifunctional enzyme whose activities and expression play crucial roles in nucleotide pool maintenance, nucleotide-dependent pathways and programmed cell death.
Cividini F +7 more
europepmc +6 more sources