Structure and evolutionary history of a large family of NLR proteins in the zebrafish [PDF]
Open Biology, 2016 Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Kerstin Howe +8 more
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Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases. [PDF]
PLoS Pathogens, 2013 Nucleotide-binding domain leucine-rich repeat (NLR) protein complexes sense infections and trigger robust immune responses in plants and humans. Activation of plant NLR resistance (R) proteins by pathogen effectors launches convergent immune responses ...
Xiquan Gao +11 more
doaj +13 more sources
Gut microbiota, NLR proteins, and intestinal homeostasis. [PDF]
J Exp Med, 2020 The gastrointestinal tract harbors a highly complex microbial community, which is referred to as gut microbiota. With increasing evidence suggesting that the imbalance of gut microbiota plays a significant role in the pathogenesis of multiple diseases, interactions between the host immune system and the gut microbiota are now attracting emerging ...
Guo H, Gibson SA, Ting JPY.
europepmc +5 more sources
The sensor domains of plant NLR proteins: more than decoys? [PDF]
Frontiers in Plant Science, 2015 Our conceptual and mechanistic understanding of how plant nucleotide-binding leucine-rich repeat (NLR or NB-LRR) proteins perceive pathogens continues to advance. NLRs are intracellular multidomain proteins that recognize pathogen-derived effectors either directly or indirectly (Jones and Dangl, 2006; Van Der Hoorn and Kamoun, 2008; Dodds and Rathjen ...
Chih-Hang eWu +5 more
doaj +8 more sources
Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae. [PDF]
PLoS ONE, 2018 Genes coding for nucleotide-binding leucine-rich repeat (LRR) receptors (NLRs) control resistance against intracellular (cell-penetrating) pathogens.
Henrik U Stotz +7 more
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Diversity, abundance, and domain architecture of plant NLR proteins in Fabaceae [PDF]
HeliyonThe resistance (R) gene family in plants is a vital component of the plant defense system, enabling host resistance against pathogens through interactions with pathogen effector proteins.
Vishal Singh Negi +2 more
doaj +2 more sources
Regulation of the Antimicrobial Response by NLR Proteins [PDF]
Immunity, 2011 Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function of multiple NLR family members has been linked, both in mice and humans, to a propensity for ...
Eran Elinav, Till Strowig
exaly +3 more sources
Plant TRAF Proteins Regulate NLR Immune Receptor Turnover [PDF]
Cell Host and Microbe, 2016 In animals, Tumor necrosis factor receptor-associated factor (TRAF) proteins are molecular adaptors that regulate innate and adaptive immunity, development, and abiotic stress responses. Although gene families encoding TRAF domain-containing proteins exhibit enriched diversity in higher plants, their biological roles are poorly defined. Here, we report
Shuai Huang, Xionghui Zhong, Kevin Ao
exaly +4 more sources
Current Opinion in Plant Biology, 2021 Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild relatives.
Javier Sánchez-Martín +1 more
exaly +3 more sources
The Landscape of Integrated Domains of Angiosperm NLR Genes Reveals Continuous Architecture Evolution of Plant Intracellular Immune Receptors [PDF]
PlantsNucleotide-binding site-leucine-rich repeat (NLR) proteins are key intracellular immune receptors in plants. Integrated domains (IDs) can occasionally be fused with NLRs, contributing to their functional diversity. However, the diversity and evolutionary
Zhen Zeng +5 more
doaj +2 more sources