Gut microbiota, NLR proteins, and intestinal homeostasis [PDF]
Journal of Experimental Medicine, 2020 An extensive crosstalk between host and intestinal microbiota contributes to the development and maturation of intestinal epithelium and immune system.
Jenny Ting, Jenny Ting
exaly +6 more sources
Structure and evolutionary history of a large family of NLR proteins in the zebrafish [PDF]
Open Biology, 2016 Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Kerstin Howe +8 more
doaj +7 more sources
NLR proteins and parasitic disease [PDF]
Immunologic Research, 2014 Parasitic diseases are a serious global health concern. Many of the most common and most severe parasitic diseases, including Chagas’ disease, leishmaniasis, and schistosomiasis, are also classified as neglected tropical diseases and are comparatively ...
Owen S Clay
exaly +6 more sources
Alien domains shaped the modular structure of plant NLR proteins [PDF]
Genome Biology and Evolution, 2019 Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses.
Antonino de Natale, Pasquale Chiaiese
exaly +9 more sources
The sensor domains of plant NLR proteins: more than decoys? [PDF]
Frontiers in Plant Science, 2015 Our conceptual and mechanistic understanding of how plant nucleotide-binding leucine-rich repeat (NLR or NB-LRR) proteins perceive pathogens continues to advance.
Chih-Hang eWu +5 more
doaj +9 more sources
Diversity, abundance, and domain architecture of plant NLR proteins in Fabaceae [PDF]
HeliyonThe resistance (R) gene family in plants is a vital component of the plant defense system, enabling host resistance against pathogens through interactions with pathogen effector proteins.
Vishal Singh Negi +2 more
doaj +6 more sources
NLRscape: an atlas of plant NLR proteins. [PDF]
Nucleic Acids Res, 2023 NLRscape is a webserver that curates a collection of over 80 000 plant protein sequences identified in UniProtKB to contain NOD-like receptor signatures, and hosts in addition a number of tools aimed at the exploration of the complex sequence landscape ...
Martin EC +6 more
europepmc +5 more sources
A new eye on NLR proteins: focused on clarity or diffused by complexity? [PDF]
Current Opinion in Immunology, 2012 The nucleotide-binding domain leucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology.
Jeffery Dangl, Marc T Nishimura
exaly +3 more sources
Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins. [PDF]
PLoS Comput Biol, 2022 NLR proteins are intracellular receptors constituting a conserved component of the innate immune system of multicellular organisms. In fungi, NLRs are characterized by high diversity of architectures and presence of amyloid signaling.
Wojciechowski JW +8 more
europepmc +2 more sources
The Arabidopsis WRR4A and WRR4B paralogous NLR proteins both confer recognition of multiple Albugo candida effectors. [PDF]
New Phytol, 2023 The oomycete Albugo candida causes white blister rust, an important disease of Brassica crops. Distinct races of A. candida are defined by their specificity for infecting different host species. The White Rust Resistance 4 (WRR4) locus in Col-0 accession
Redkar A +10 more
europepmc +2 more sources