Results 1 to 10 of about 122,087 (266)
Diversity, abundance, and domain architecture of plant NLR proteins in Fabaceae [PDF]
HeliyonThe resistance (R) gene family in plants is a vital component of the plant defense system, enabling host resistance against pathogens through interactions with pathogen effector proteins.
Vishal Singh Negi +2 more
doaj +7 more sources
Structure and evolutionary history of a large family of NLR proteins in the zebrafish [PDF]
Open Biology, 2016 Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Kerstin Howe +8 more
doaj +8 more sources
Alien domains shaped the modular structure of plant NLR proteins [PDF]
Genome Biology and Evolution, 2019 Abstract Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses. A multi-taxa reconstruction of NB-domain associations allowed us to identify the first NB-LRR arrangement in the Chlorophyta division of the ...
Giuseppe Andolfo +2 more
exaly +9 more sources
The sensor domains of plant NLR proteins: more than decoys? [PDF]
Frontiers in Plant Science, 2015 Our conceptual and mechanistic understanding of how plant nucleotide-binding leucine-rich repeat (NLR or NB-LRR) proteins perceive pathogens continues to advance. NLRs are intracellular multidomain proteins that recognize pathogen-derived effectors either directly or indirectly (Jones and Dangl, 2006; Van Der Hoorn and Kamoun, 2008; Dodds and Rathjen ...
Chih-Hang eWu +5 more
doaj +10 more sources
NLRscape: an atlas of plant NLR proteins. [PDF]
Nucleic Acids Res, 2023 AbstractNLRscape is a webserver that curates a collection of over 80 000 plant protein sequences identified in UniProtKB to contain NOD-like receptor signatures, and hosts in addition a number of tools aimed at the exploration of the complex sequence landscape of this class of plant proteins.
Martin EC +6 more
europepmc +4 more sources
Gut microbiota, NLR proteins, and intestinal homeostasis [PDF]
Journal of Experimental Medicine, 2020 The gastrointestinal tract harbors a highly complex microbial community, which is referred to as gut microbiota. With increasing evidence suggesting that the imbalance of gut microbiota plays a significant role in the pathogenesis of multiple diseases, interactions between the host immune system and the gut microbiota are now attracting emerging ...
Sara A Gibson +2 more
exaly +5 more sources
Pyrin- and CARD-only proteins as regulators of NLR functions [PDF]
Frontiers in Immunology, 2013 Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and ...
Hongnga T. Le +2 more
doaj +4 more sources
Regulation of the Antimicrobial Response by NLR Proteins [PDF]
Immunity, 2011 Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function of multiple NLR family members has been linked, both in mice and humans, to a propensity for ...
Eran Elinav +2 more
exaly +4 more sources
NLR proteins and parasitic disease [PDF]
Immunologic Research, 2014 Parasitic diseases are a serious global health concern. Many of the most common and most severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis, are also classified as neglected tropical diseases and are comparatively less studied than infectious diseases prevalent in high income nations.
Gwendolyn M Clay, Fayyaz S Sutterwala
exaly +5 more sources
Evolution and conservation of plant NLR functions [PDF]
Frontiers in Immunology, 2013 In plants and animals, nucleotide-binding domain and leucine-rich repeats (NLR)–containing proteins play pivotal roles in innate immunity. Despite their similar biological functions and protein architecture, comparative genome-wide analyses of NLRs and ...
Florence eJacob +3 more
doaj +5 more sources