Results 41 to 50 of about 122,087 (266)

zfBED-NLR proteins across the Oryzeae.

, 2020
(a) Xo1 clades I and II from an NB-ARC domain-based maximum likelihood tree of 5,078 predicted NLR proteins from representative Oryzeae genomes. Clade I proteins are indicated by orange shading, clade II by purple, and presence of zfBED domain by dark ...
Lindsay R. Triplett (3156762), Steven L. Salzberg (8363331), Andrew C. Read (8363322), Michael D. Purugganan (7882301), Jan E. Leach (6647660), Geo Pertea (1207), Matthew J. Moscou (8363325), Aleksey V. Zimin (8363328), Rachel S. Meyer (2008639), Adam J. Bogdanove (8363334)   +9 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

mBio, 2013
When microbes contaminate the macrophage cytoplasm, leukocytes undergo a proinflammatory death that is initiated by nucleotide-binding-domain-, leucine-rich-repeat-containing proteins (NLR proteins) that bind and activate caspase-1.
Brenda G. Byrne, Jean-Francois Dubuisson, Amrita D. Joshi, Jenny J. Persson, Michele S. Swanson   +4 more
doaj   +1 more source

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network.

PLoS Biology, 2021
In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can form receptor networks to confer hypersensitive cell death and innate immunity.
Lida Derevnina, Mauricio P Contreras, Hiroaki Adachi, Jessica Upson, Angel Vergara Cruces, Rongrong Xie, Jan Skłenar, Frank L H Menke, Sam T Mugford, Dan MacLean, Wenbo Ma, Saskia A Hogenhout, Aska Goverse, Abbas Maqbool, Chih-Hang Wu, Sophien Kamoun   +15 more
doaj   +1 more source

Nucleotide-Binding Domain Leucine-Rich Repeat Containing Proteins and Intestinal Microbiota: Pivotal Players in Colitis and Colitis-Associated Cancer Development

Frontiers in Immunology, 2018
The nucleotide-binding domain leucine-rich repeat containing (NLR) proteins play a fundamental role in innate immunity and intestinal tissue repair.
Anna Prossomariti, Anna Prossomariti, Harry Sokol, Harry Sokol, Luigi Ricciardiello   +4 more
doaj   +1 more source

Wheat Disease Resistance Genes and Their Diversification Through Integrated Domain Fusions

Frontiers in Genetics, 2020
Plants are in a constant evolutionary arms race with their pathogens. At the molecular level, the plant nucleotide-binding leucine-rich repeat receptors (NLRs) family has coevolved with rapidly evolving pathogen effectors.
Ethan J. Andersen, Madhav P. Nepal, Jordan M. Purintun, Dillon Nelson, Glykeria Mermigka, Panagiotis F. Sarris, Panagiotis F. Sarris, Panagiotis F. Sarris   +7 more
doaj   +1 more source

Structural basis for specific flagellin recognition by the NLR protein NAIP5 [PDF]

Cell Research, 2017
The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive.
Yang, Xinru, Yang, Fan, Wang, Weiguang, Lin, Guangzhong, Hu, Zehan, Han, Zhifu, Qi, Yijun, Wang, Jiawei, Sui, Sen-Fang, Chai, Jijie, Zhang, Liman   +10 more
openaire   +4 more sources

The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition [PDF]

Cell Reports, 2017
NLRP6 is a Nod-like receptor expressed in the intestinal epithelium. Previous studies reported a protective role for NLRP6 against intestinal injury and colitis-associated carcinogenesis via the regulation and establishment of a healthy microbiota. However, these results were not obtained using littermate animals, leaving the possibility that the pro ...
Paul Lemire, Susan J. Robertson, Heather Maughan, Ivan Tattoli, Catherine J. Streutker, Jaye M. Platnich, Daniel A. Muruve, Dana J. Philpott, Stephen E. Girardin   +8 more
openaire   +3 more sources

The Ups and Downs of Plant NLR Expression During Pathogen Infection

Frontiers in Plant Science, 2022
Plant Nucleotide binding-Leucine rich repeat (NLR) proteins play a significant role in pathogen detection and the activation of effector-triggered immunity.
Alicia Fick, Alicia Fick, Velushka Swart, Velushka Swart, Noëlani van den Berg, Noëlani van den Berg   +5 more
doaj   +1 more source