Results 41 to 50 of about 8,284,629 (305)

Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae. [PDF]

PLoS ONE, 2018
Genes coding for nucleotide-binding leucine-rich repeat (LRR) receptors (NLRs) control resistance against intracellular (cell-penetrating) pathogens.
Henrik U Stotz, Pascoe J Harvey, Parham Haddadi, Alla Mashanova, Andreas Kukol, Nicholas J Larkan, M Hossein Borhan, Bruce D L Fitt   +7 more
doaj   +1 more source

Regulation of NLR stability in plant immunity [PDF]

Frontiers of Agricultural Science and Engineering, 2019
Plant nucleotide binding domain and leucine-rich repeat (NLR) receptors recognize pathogen effectors directly or indirectly and mediate innate immune responses.
Tao WANG, Jiaxin LI, Qian-Hua SHEN
doaj   +1 more source

Molecular and functional analyses of a maize autoactive NB-LRR protein identify precise structural requirements for activity.

PLoS Pathogens, 2015
Plant disease resistance is often mediated by nucleotide binding-leucine rich repeat (NLR) proteins which remain auto-inhibited until recognition of specific pathogen-derived molecules causes their activation, triggering a rapid, localized cell death ...
Guan-Feng Wang, Jiabing Ji, Farid El-Kasmi, Jeffery L Dangl, Guri Johal, Peter J Balint-Kurti   +5 more
doaj   +1 more source

New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain

Nature Communications, 2022
Plant NLR proteins trigger immune responses upon recognition of pathogen effectors. Here the authors show that the integrated decoy domain of the rice NLR RGA5 can be engineered to trigger immune responses upon binding a non-cognate effector.
Stella Cesari, Yuxuan Xi, Nathalie Declerck, Véronique Chalvon, Léa Mammri, Martine Pugnière, Corinne Henriquet, Karine de Guillen, Vincent Chochois, André Padilla, Thomas Kroj   +10 more
doaj   +1 more source

Construction and Identification of an NLR-Associated Prognostic Signature Revealing the Heterogeneous Immune Response in Skin Cutaneous Melanoma

Clinical, Cosmetic and Investigational Dermatology, 2023
Yi Geng,1 Yu-Jie Sun,1 Hao Song,1 Qiu-Ju Miao,1 Yi-Fei Wang,1 Jin-Liang Qi,2 Xiu-Lian Xu,1 Jian-Fang Sun1 1Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Nanjing, 210042, People’s Republic of China; 2State
Geng Y, Sun YJ, Song H, Miao QJ, Wang YF, Qi JL, Xu XL, Sun JF   +7 more
doaj  

Evolution and conservation of plant NLR functions

Frontiers in Immunology, 2013
In plants and animals, nucleotide-binding domain and leucine-rich repeats (NLR)–containing proteins play pivotal roles in innate immunity. Despite their similar biological functions and protein architecture, comparative genome-wide analyses of NLRs and ...
Florence eJacob, Florence eJacob, Saskia eVernaldi, Takaki eMaekawa   +3 more
doaj   +1 more source

Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity

Nature Communications, 2021
For defence, plants deploy nucleotide binding, leucine-rich repeat (NLR) immune receptors to detect pathogens that signal via modular networks of downstream proteins.
Xinhua Sun, Dmitry Lapin, Joanna M. Feehan, Sara C. Stolze, Katharina Kramer, Joram A. Dongus, Jakub Rzemieniewski, Servane Blanvillain-Baufumé, Anne Harzen, Jaqueline Bautor, Paul Derbyshire, Frank L. H. Menke, Iris Finkemeier, Hirofumi Nakagami, Jonathan D. G. Jones, Jane E. Parker   +15 more
doaj   +1 more source

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

mBio, 2013
When microbes contaminate the macrophage cytoplasm, leukocytes undergo a proinflammatory death that is initiated by nucleotide-binding-domain-, leucine-rich-repeat-containing proteins (NLR proteins) that bind and activate caspase-1.
Brenda G. Byrne, Jean-Francois Dubuisson, Amrita D. Joshi, Jenny J. Persson, Michele S. Swanson   +4 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Nucleotide-Binding Domain Leucine-Rich Repeat Containing Proteins and Intestinal Microbiota: Pivotal Players in Colitis and Colitis-Associated Cancer Development

Frontiers in Immunology, 2018
The nucleotide-binding domain leucine-rich repeat containing (NLR) proteins play a fundamental role in innate immunity and intestinal tissue repair.
Anna Prossomariti, Anna Prossomariti, Harry Sokol, Harry Sokol, Luigi Ricciardiello   +4 more
doaj   +1 more source