Results 21 to 30 of about 134,694 (275)

Possible Protective Role of NLRC4 Inflammasome in Periodontal Diseases: A Preliminary Study

Dental Hypotheses, 2021
Introduction: Inflammasomes are multiprotein complexes, which regulate proinflammatory cytokines, Interleukin-18 (IL-18), and Interleukin-1β (IL-1β) that are associated with periodontal breakdown.
Sneha Parameswaran, Vanaja Krishna Naik, Kubra Aral, Sugirtharaj Gunasekaran, Devapriya Appukuttan, Michael R Milward, Ramya Ramadoss   +6 more
doaj   +1 more source

Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition

Nature Communications, 2023
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity.
Arsheed H. Sheikh, Iosif Zacharia, Alonso J. Pardal, Ana Dominguez-Ferreras, Daniela J. Sueldo, Jung-Gun Kim, Alexi Balmuth, Jose R. Gutierrez, Brendon F. Conlan, Najeeb Ullah, Olivia M. Nippe, Anil M. Girija, Chih-Hang Wu, Guido Sessa, Alexandra M. E. Jones, Murray R. Grant, Miriam L. Gifford, Mary Beth Mudgett, John P. Rathjen, Vardis Ntoukakis   +19 more
doaj   +1 more source

Editorial: NLR-Protein Functions in Immunity [PDF]

Frontiers in Immunology, 2015
Since Janeway (1) and Matzinger (2) put forward two distinct concepts of innate immune recognition, arguing that the driving force that initiates immune reponses is the recognition of microbial patterns or endogenous danger signals, respectively, we have acquired a tremendous wealth of knowledge of the protein families involved.
Fritz, Jörg H., Kufer, Thomas A.
openaire   +2 more sources

Genome-wide identification and analysis of the NLR gene family in Medicago ruthenica

Frontiers in Genetics, 2023
Medicago ruthenica, important forage in the legume family, possesses high nutritional value and carries abundant tolerance genes. This study used whole-genome data of M.
Chunyan Tong, Chunyan Tong, Yutong Zhang, Yutong Zhang, Fengling Shi, Fengling Shi   +5 more
doaj   +1 more source

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. [PDF]

Proc Natl Acad Sci U S A, 2016
Casey LW, Lavrencic P, Bentham AR, Cesari S, Ericsson DJ, Croll T, Turk D, Anderson PA, Mark AE, Dodds PN, Mobli M, Kobe B, Williams SJ.   +12 more
europepmc   +2 more sources

Structural mechanism of heavy metal-associated integrated domain engineering of paired nucleotide-binding and leucine-rich repeat proteins in rice

Frontiers in Plant Science, 2023
Plant nucleotide-binding and leucine-rich repeat (NLR) proteins are immune sensors that detect pathogen effectors and initiate a strong immune response.
Liwei Guo, Liwei Guo, Yuanyu Mu, Yuanyu Mu, Dongli Wang, Chen Ye, Chen Ye, Shusheng Zhu, Shusheng Zhu, Hong Cai, Hong Cai, Youyong Zhu, Youyong Zhu, Youliang Peng, Junfeng Liu, Xiahong He, Xiahong He, Xiahong He   +17 more
doaj   +1 more source

Pathogen manipulation of chloroplast function triggers a light-dependent immune recognition [PDF]

, 2020
In plants and animals, nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune sensors that recognize and eliminate a wide range of invading pathogens.
Bozkurt, Tolga O., Dong, Suomeng, Duggan, Cian, Gao, Chuyun, Huang, Jie, Kamoun, Sophien, Savage, Zachary, Sun, Biying, Vleeshouwers, Vivianne G. A. A., Wang, Yuanchao, Wu, Chih-Hang, Xu, Huawei, Yan, Tingxiu, Zhang, Fan   +13 more
core   +1 more source

NLR-protein functions in immunity

Frontiers in Immunology, 2015
The Nod-like receptor (NLR) family of proteins are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial ...
Jorg Hermann eFritz, Thomas A. Kufer
openaire   +5 more sources

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens. [PDF]

, 2016
BACKGROUND: Plants deploy immune receptors to detect pathogen-derived molecules and initiate defense responses. Intracellular plant immune receptors called nucleotide-binding leucine-rich repeat (NLR) proteins contain a central nucleotide-binding (NB ...
Cevik, Volkan, Dagdas, Gulay, Jones, Jonathan, Krasileva, Ksenia, Sarris, Panagiotis   +4 more
core   +11 more sources

Recent advances in plant NLR structure, function, localization and signaling

Frontiers in Immunology, 2013
Nucleotide-binding domain leucine-rich repeat (NLR) proteins play a central role in the innate immune systems of plants and vertebrates. In plants, NLR proteins function as intracellular receptors that detect pathogen effector proteins directly, or ...
Dong eQi, Roger W Innes
doaj   +1 more source