Results 21 to 30 of about 122,087 (266)

Diversification of molecular pattern recognition in bacterial NLR-like proteins

Nature Communications
Antiviral STANDs (Avs) are bacterial anti-phage proteins evolutionarily related to immune pattern recognition receptors of the NLR family. Type 2 Avs proteins (Avs2) were suggested to recognize the phage large terminase subunit as a signature of phage ...
Nathalie Béchon, Nitzan Tal, Avigail Stokar-Avihail, Alon Savidor, Meital Kupervaser, Sarah Melamed, Gil Amitai, Rotem Sorek   +7 more
doaj   +4 more sources

Plant NLR immunity activation and execution: a biochemical perspective

Open Biology
Plants deploy cell-surface and intracellular receptors to detect pathogen attack and trigger innate immune responses. Inside host cells, families of nucleotide-binding/leucine-rich repeat (NLR) proteins serve as pathogen sensors or downstream mediators ...
Federica Locci, Jane E. Parker
doaj   +3 more sources

Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins. [PDF]

PLoS Comput Biol, 2022
NLR proteins are intracellular receptors constituting a conserved component of the innate immune system of cellular organisms. In fungi, NLRs are characterized by high diversity of architectures and presence of amyloid signaling.
Wojciechowski JW, Tekoglu E, Gąsior-Głogowska M, Coustou V, Szulc N, Szefczyk M, Kopaczyńska M, Saupe SJ, Dyrka W.   +8 more
europepmc   +2 more sources

The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins. [PDF]

Int J Mol Sci, 2021
In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and leucine-rich-repeat
León Machado JA, Steimle V.
europepmc   +2 more sources

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Lachlan W Casey, Peter Lavrencic, Adam R Bentham   +2 more
exaly   +2 more sources

Possible Protective Role of NLRC4 Inflammasome in Periodontal Diseases: A Preliminary Study

Dental Hypotheses, 2021
Introduction: Inflammasomes are multiprotein complexes, which regulate proinflammatory cytokines, Interleukin-18 (IL-18), and Interleukin-1β (IL-1β) that are associated with periodontal breakdown.
Sneha Parameswaran, Vanaja Krishna Naik, Kubra Aral, Sugirtharaj Gunasekaran, Devapriya Appukuttan, Michael R Milward, Ramya Ramadoss   +6 more
doaj   +1 more source

DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25.

PLoS Biology
Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of the human innate immune system. Mammalian nucleotide-binding and leucine-rich repeat containing proteins (NLRs) and bacterial NLR-related ...
Amy N Conte, Madison E Ruchel, Samantha M Ridgeway, Emily M Kibby, Toni A Nagy, Aaron T Whiteley   +5 more
doaj   +3 more sources

Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition

Nature Communications, 2023
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity.
Arsheed H. Sheikh, Iosif Zacharia, Alonso J. Pardal, Ana Dominguez-Ferreras, Daniela J. Sueldo, Jung-Gun Kim, Alexi Balmuth, Jose R. Gutierrez, Brendon F. Conlan, Najeeb Ullah, Olivia M. Nippe, Anil M. Girija, Chih-Hang Wu, Guido Sessa, Alexandra M. E. Jones, Murray R. Grant, Miriam L. Gifford, Mary Beth Mudgett, John P. Rathjen, Vardis Ntoukakis   +19 more
doaj   +1 more source

Genome-wide identification and analysis of the NLR gene family in Medicago ruthenica

Frontiers in Genetics, 2023
Medicago ruthenica, important forage in the legume family, possesses high nutritional value and carries abundant tolerance genes. This study used whole-genome data of M.
Chunyan Tong, Chunyan Tong, Yutong Zhang, Yutong Zhang, Fengling Shi, Fengling Shi   +5 more
doaj   +1 more source

Structural mechanism of heavy metal-associated integrated domain engineering of paired nucleotide-binding and leucine-rich repeat proteins in rice

Frontiers in Plant Science, 2023
Plant nucleotide-binding and leucine-rich repeat (NLR) proteins are immune sensors that detect pathogen effectors and initiate a strong immune response.
Liwei Guo, Liwei Guo, Yuanyu Mu, Yuanyu Mu, Dongli Wang, Chen Ye, Chen Ye, Shusheng Zhu, Shusheng Zhu, Hong Cai, Hong Cai, Youyong Zhu, Youyong Zhu, Youliang Peng, Junfeng Liu, Xiahong He, Xiahong He, Xiahong He   +17 more
doaj   +1 more source