Results 21 to 30 of about 8,284,629 (305)

Pyrin- and CARD-only proteins as regulators of NLR functions [PDF]

Frontiers in Immunology, 2013
Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and ...
Hongnga T. Le, Hongnga T. Le, Jonathan A. Harton   +2 more
doaj   +3 more sources

The wheels of destruction: Plant NLR immune receptors are mobile and structurally dynamic disease resistance proteins

Current Opinion in Plant Biology, 2023
Nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune receptors that restrict plant invasion by pathogens. Most NLRs operate in intricate networks to detect pathogen effectors in a robust and efficient manner. NLRs are not static
Philip Carella, Enoch Lok Him Yuen, Tolga O Bozkurt   +2 more
exaly   +2 more sources

Resurrection of plant disease resistance proteins via helper NLR bioengineering [PDF]

Science Advances, 2023
Parasites counteract host immunity by suppressing helper NLR proteins that function as central nodes in immune receptor networks. Understanding the mechanisms of immunosuppression can lead to strategies for bioengineering disease resistance.
Mauricio P. Contreras, Pai Hsuan, M. Selvaraj, AmirAli Toghani, D. M. Lawson, Yasin Tumtas, Cian Duggan, Enoch Lok Him Yuen, C. E. Stevenson, A. Harant, A. Maqbool, Chih-hang Wu, T. Bozkurt, S. Kamoun, L. Derevnina   +14 more
semanticscholar   +4 more sources

Cytosolic activation of cell death and stem rust resistance by cereal MLA-family CC-NLR proteins. [PDF]

Proc Natl Acad Sci U S A, 2016
Cesari S, Moore J, Chen C, Webb D, Periyannan S, Mago R, Bernoux M, Lagudah ES, Dodds PN.   +8 more
europepmc   +2 more sources

Plant NLR receptor proteins and their potential in the development of durable genetic resistance to biotic stresses

Biotechnology Research and Innovation, 2019
In order to meet global food security demands in the next decades, considerable changes are required for sustainable agriculture in the context of plant disease, with sufficient food production depending on the development of durable genetically disease ...
Fernando Campos de Assis Fonseca, Robert Miller, Amanda Cristina de Araujo   +2 more
exaly   +2 more sources

A novel conserved mechanism for plant NLR protein pairs: the ‘integrated decoy’ hypothesis [PDF]

Frontiers in Plant Science, 2014
Plant immunity is often triggered by the specific recognition of pathogen effectors by intracellular nucleotide-binding, leucine-rich repeat (NLR) receptors.
Stella ecesari, Stella ecesari, Maud eBernoux, Philippe eMoncuquet, Thomas eKroj, Peter N Dodds   +5 more
doaj   +6 more sources

Bacterial NLR-related proteins protect against phage

bioRxiv, 2022
Bacteria use a wide range of immune systems to counter phage infection. A subset of these genes share homology with components of eukaryotic immune systems, suggesting that eukaryotes horizontally acquired certain innate immune genes from bacteria.
Emily M. Kibby, Amy N. Conte, A. Burroughs, Toni A. Nagy, J. Vargas, Lindsay A. Whalen, L. Aravind, A. T. Whiteley   +7 more
semanticscholar   +2 more sources

Assembly and functional mechanisms of plant NLR resistosomes

Current Opinion in Structural Biology
Nucleotide-binding and leucine-rich repeat (NLR) proteins are essential intracellular immune receptors in both animal and plant kingdoms. Sensing of pathogen-derived signals induces oligomerization of NLR proteins, culminating in the formation of higher ...
Jijie Chai, Han Zhifu, Shijia Huang
exaly   +2 more sources

Possible Protective Role of NLRC4 Inflammasome in Periodontal Diseases: A Preliminary Study

Dental Hypotheses, 2021
Introduction: Inflammasomes are multiprotein complexes, which regulate proinflammatory cytokines, Interleukin-18 (IL-18), and Interleukin-1β (IL-1β) that are associated with periodontal breakdown.
Sneha Parameswaran, Vanaja Krishna Naik, Kubra Aral, Sugirtharaj Gunasekaran, Devapriya Appukuttan, Michael R Milward, Ramya Ramadoss   +6 more
doaj   +1 more source

The BTB/POZ-MATH Protein ZmBPM1 Interacts With Autophagy-related Protein ZmATG6 and Modulates the NLR Protein Rp1-D21-Mediated Defense Response in Maize. [PDF]

Adv Sci (Weinh)
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Tang CX, Liu TT, Ge QD, Liu XY, Wang W, Sun Y, Liu Y, Li F, Wang GF.   +8 more
europepmc   +2 more sources