Results 11 to 20 of about 8,284,629 (305)
Current Opinion in Plant Biology, 2021 Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild ...
Javier Sánchez-Martín, Beat Keller
exaly +4 more sources
Assessing ATP binding and hydrolysis by NLR proteins. [PDF]
Methods Mol Biol, 2013 Summary Nucleotide-binding and leucine rich repeat domain-containing proteins (NLR) are central to the formation of many inflammasome complexes. Several inflammasome forming NLR proteins are known to be ATPases, but the nucleotide binding specificity of ...
Mo J, Duncan JA.
europepmc +5 more sources
Diversification of molecular pattern recognition in bacterial NLR-like proteins
Nature CommunicationsAntiviral STANDs (Avs) are bacterial anti-phage proteins evolutionarily related to immune pattern recognition receptors of the NLR family. Type 2 Avs proteins (Avs2) were suggested to recognize the phage large terminase subunit as a signature of phage ...
Nathalie Béchon +7 more
doaj +5 more sources
The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins. [PDF]
Int J Mol Sci, 2021 In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and leucine-rich-repeat
León Machado JA, Steimle V.
europepmc +2 more sources
The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Daniel J Ericsson +2 more
exaly +3 more sources
LRRpredictor-A New LRR Motif Detection Method for Irregular Motifs of Plant NLR Proteins Using an Ensemble of Classifiers. [PDF]
Genes (Basel), 2020 Leucine-rich-repeats (LRRs) belong to an archaic procaryal protein architecture that is widely involved in protein–protein interactions. In eukaryotes, LRR domains developed into key recognition modules in many innate immune receptor classes.
Martin EC +7 more
europepmc +2 more sources
Regulation of the Antimicrobial Response by NLR Proteins [PDF]
Immunity, 2011 Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function of multiple NLR family members has been linked, both in mice and humans, to a propensity for ...
Eran Elinav +2 more
exaly +4 more sources
The Biophysical Characterisation and SAXS Analysis of Human NLRP1 Uncover a New Level of Complexity of NLR Proteins. [PDF]
PLoS One, 2016 NOD-like receptors represent an important class of germline-encoded pattern recognition receptors that play key roles in the regulation of inflammatory signalling pathways.
Martino L +5 more
europepmc +2 more sources
Annual Review of Phytopathology, 2018 Plants employ a diverse intracellular system of NLR (nucleotide binding-leucine-rich repeat) innate immune receptors to detect pathogens of all types. These receptors represent valuable agronomic traits that plant breeders rely on to maximize yield in ...
Freddy Monteiro, Marc T Nishimura
exaly +2 more sources