Results 11 to 20 of about 134,694 (275)

Evolution and conservation of plant NLR functions

Frontiers in Immunology, 2013
In plants and animals, nucleotide-binding domain and leucine-rich repeats (NLR)–containing proteins play pivotal roles in innate immunity. Despite their similar biological functions and protein architecture, comparative genome-wide analyses of NLRs and ...
Florence eJacob, Florence eJacob, Saskia eVernaldi, Takaki eMaekawa   +3 more
doaj   +3 more sources

Pyrin- and CARD-only proteins as regulators of NLR functions [PDF]

Frontiers in Immunology, 2013
Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo-domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and ...
Hongnga T. Le, Hongnga T. Le, Jonathan A. Harton   +2 more
doaj   +3 more sources

NLRscape: an atlas of plant NLR proteins. [PDF]

Nucleic Acids Res, 2023
AbstractNLRscape is a webserver that curates a collection of over 80 000 plant protein sequences identified in UniProtKB to contain NOD-like receptor signatures, and hosts in addition a number of tools aimed at the exploration of the complex sequence landscape of this class of plant proteins.
Martin EC, Ion CF, Ifrimescu F, Spiridon L, Bakker J, Goverse A, Petrescu AJ.   +6 more
europepmc   +3 more sources

A novel conserved mechanism for plant NLR protein pairs: the ‘integrated decoy’ hypothesis [PDF]

Frontiers in Plant Science, 2014
Plant immunity is often triggered by the specific recognition of pathogen effectors by intracellular nucleotide-binding, leucine-rich repeat (NLR) receptors.
Stella ecesari, Stella ecesari, Maud eBernoux, Philippe eMoncuquet, Thomas eKroj, Peter N Dodds   +5 more
doaj   +6 more sources

Diversification of molecular pattern recognition in bacterial NLR-like proteins

Nature Communications
Antiviral STANDs (Avs) are bacterial anti-phage proteins evolutionarily related to immune pattern recognition receptors of the NLR family. Type 2 Avs proteins (Avs2) were suggested to recognize the phage large terminase subunit as a signature of phage ...
Nathalie Béchon, Nitzan Tal, Avigail Stokar-Avihail, Alon Savidor, Meital Kupervaser, Sarah Melamed, Gil Amitai, Rotem Sorek   +7 more
doaj   +4 more sources

NLR proteins and parasitic disease. [PDF]

Immunol Res, 2014
Parasitic diseases are a serious global health concern. Many of the most common and most severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis, are also classified as neglected tropical diseases and are comparatively less studied than infectious diseases prevalent in high income nations.
Clay GM, Sutterwala FS, Wilson ME.
europepmc   +4 more sources

Pan-NLRome of Spinacia facilitates the rapid discovery of downy mildew resistance genes [PDF]

Frontiers in Plant Science
Plant disease resistance is typically conferred by nucleotide-binding site leucine-rich repeats (NLR) proteins; however, the diversity of NLR genes in spinach has remained largely unexplored. We identified 2,549 NLR genes across 19 Spinacia assemblies of
Hongbing She, Hongbing She, Huiyu Wang, Zhaosheng Xu, Helong Zhang, Zhiyuan Liu, Zhiyuan Liu   +6 more
doaj   +2 more sources

Assessing ATP binding and hydrolysis by NLR proteins. [PDF]

Methods Mol Biol, 2013
Nucleotide-binding and leucine rich repeat domain-containing proteins (NLRs) are central to the formation of many inflammasome complexes. Several inflammasome forming NLR proteins are known to be ATPases, but the nucleotide binding specificity of many remains to be characterized. The oligomerization of NLR proteins and assembly of inflammasomes require
Mo J, Duncan JA.
europepmc   +4 more sources

Alien Domains Shaped the Modular Structure of Plant NLR Proteins. [PDF]

Genome Biol Evol, 2019
Abstract Plant innate immunity mostly relies on nucleotide-binding (NB) and leucine-rich repeat (LRR) intracellular receptors to detect pathogen-derived molecules and to induce defense responses. A multi-taxa reconstruction of NB-domain associations allowed us to identify the first NB-LRR arrangement in the Chlorophyta division of the ...
Andolfo G, Di Donato A, Chiaiese P, De Natale A, Pollio A, Jones JDG, Frusciante L, Ercolano MR.   +7 more
europepmc   +7 more sources

DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25.

PLoS Biology
Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of the human innate immune system. Mammalian nucleotide-binding and leucine-rich repeat containing proteins (NLRs) and bacterial NLR-related ...
Amy N Conte, Madison E Ruchel, Samantha M Ridgeway, Emily M Kibby, Toni A Nagy, Aaron T Whiteley   +5 more
doaj   +2 more sources