Results 31 to 40 of about 8,284,629 (305)

The role of NLR proteins in Leishmaniasis

, 2016
<p>Leishmania species are vector-borne protozoan parasites that cause a spectrum of human diseases, with an estimated 12 million people infected in 88 countries. Inflammation plays distinct roles in the different clinical syndromes. Visceral leishmaniasis, in which parasites migrate from the site of infection and proliferate in liver and spleen ...
Gwendolyn M. Clay
semanticscholar   +2 more sources

Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition

Nature Communications, 2023
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity.
Arsheed H. Sheikh, Iosif Zacharia, Alonso J. Pardal, Ana Dominguez-Ferreras, Daniela J. Sueldo, Jung-Gun Kim, Alexi Balmuth, Jose R. Gutierrez, Brendon F. Conlan, Najeeb Ullah, Olivia M. Nippe, Anil M. Girija, Chih-Hang Wu, Guido Sessa, Alexandra M. E. Jones, Murray R. Grant, Miriam L. Gifford, Mary Beth Mudgett, John P. Rathjen, Vardis Ntoukakis   +19 more
doaj   +1 more source

Genome-wide identification and analysis of the NLR gene family in Medicago ruthenica

Frontiers in Genetics, 2023
Medicago ruthenica, important forage in the legume family, possesses high nutritional value and carries abundant tolerance genes. This study used whole-genome data of M.
Chunyan Tong, Chunyan Tong, Yutong Zhang, Yutong Zhang, Fengling Shi, Fengling Shi   +5 more
doaj   +1 more source

Editorial: NLR-Protein Functions in Immunity [PDF]

Frontiers in Immunology, 2015
Since Janeway (1) and Matzinger (2) put forward two distinct concepts of innate immune recognition, arguing that the driving force that initiates immune reponses is the recognition of microbial patterns or endogenous danger signals, respectively, we have acquired a tremendous wealth of knowledge of the protein families involved.
Fritz, Jörg H., Kufer, Thomas A.
openaire   +2 more sources

DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25.

PLoS Biology
Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of the human innate immune system. Mammalian nucleotide-binding and leucine-rich repeat containing proteins (NLRs) and bacterial NLR-related ...
Amy N Conte, Madison E Ruchel, Samantha M Ridgeway, Emily M Kibby, Toni A Nagy, Aaron T Whiteley   +5 more
doaj   +3 more sources

Structural mechanism of heavy metal-associated integrated domain engineering of paired nucleotide-binding and leucine-rich repeat proteins in rice

Frontiers in Plant Science, 2023
Plant nucleotide-binding and leucine-rich repeat (NLR) proteins are immune sensors that detect pathogen effectors and initiate a strong immune response.
Liwei Guo, Liwei Guo, Yuanyu Mu, Yuanyu Mu, Dongli Wang, Chen Ye, Chen Ye, Shusheng Zhu, Shusheng Zhu, Hong Cai, Hong Cai, Youyong Zhu, Youyong Zhu, Youliang Peng, Junfeng Liu, Xiahong He, Xiahong He, Xiahong He   +17 more
doaj   +1 more source

NLR-protein functions in immunity

Frontiers in Immunology, 2015
The Nod-like receptor (NLR) family of proteins are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial ...
Jorg Hermann eFritz, Thomas A. Kufer
openaire   +5 more sources

Regulation of intestinal microbiota by the NLR protein family [PDF]

International Immunology, 2013
Abstract The human intestine harbors a diverse microbial community consisting of a large number of bacteria and other micro-organisms that have co-evolved with the host intestinal immune system. During this process, microbiota and the host immune system shape one another by various mechanisms to achieve a successful symbiotic ...
Amlan, Biswas, Koichi S, Kobayashi
openaire   +2 more sources

The putative kinase substrate MUSE7 negatively impacts the accumulation of NLR proteins [PDF]

The Plant Journal, 2017
SummaryStringent modulation of immune signaling in plants is necessary to enable a rapid response to pathogen attack without spurious defense activation. To identify genes involved in plant immunity, a forward genetic screen for enhancers of the autoimmune snc1 (suppressor of npr1, constitutive 1) mutant was conducted.
Kaeli C. M. Johnson, Jin Zhao, Zhongshou Wu, Charlotte Roth, Volker Lipka, M. Wiermer, Xin Li   +6 more
semanticscholar   +4 more sources

Recent advances in plant NLR structure, function, localization and signaling

Frontiers in Immunology, 2013
Nucleotide-binding domain leucine-rich repeat (NLR) proteins play a central role in the innate immune systems of plants and vertebrates. In plants, NLR proteins function as intracellular receptors that detect pathogen effector proteins directly, or ...
Dong eQi, Roger W Innes
doaj   +1 more source