Results 51 to 60 of about 8,284,629 (305)

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network.

PLoS Biology, 2021
In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can form receptor networks to confer hypersensitive cell death and innate immunity.
Lida Derevnina, Mauricio P Contreras, Hiroaki Adachi, Jessica Upson, Angel Vergara Cruces, Rongrong Xie, Jan Skłenar, Frank L H Menke, Sam T Mugford, Dan MacLean, Wenbo Ma, Saskia A Hogenhout, Aska Goverse, Abbas Maqbool, Chih-Hang Wu, Sophien Kamoun   +15 more
doaj   +1 more source

The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis.

The Plant Cell, 2023
In the presence of pathogenic bacteria, plants close their stomata to prevent pathogen entry. Intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogenic effectors and activate effector-triggered immune responses ...
Hanling Wang, Su-Sheng Song, Shang Gao, Qiangsheng Yu, Haibo Zhang, Xiulin Cui, Jun Fan, Xiufang Xin, Yule Liu, B. Staskawicz, Tiancong Qi   +10 more
semanticscholar   +1 more source

NLR proteins: integral members of innate immunity and mediators of inflammatory diseases [PDF]

Journal of Leukocyte Biology, 2008
AbstractThe innate immune system is the first line of defense against microorganisms and is conserved in plants and animals. The nucleotide-binding domain, leucine rich containing (NLR) protein family is a recent addition to the members of innate immunity effector molecules.
Jeanette M. Wilmanski, Tanja Petnicki-Ocwieja, Koichi S. Kobayashi   +2 more
semanticscholar   +3 more sources

The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition [PDF]

Cell Reports, 2017
NLRP6 is a Nod-like receptor expressed in the intestinal epithelium. Previous studies reported a protective role for NLRP6 against intestinal injury and colitis-associated carcinogenesis via the regulation and establishment of a healthy microbiota. However, these results were not obtained using littermate animals, leaving the possibility that the pro ...
Paul Lemire, Susan J. Robertson, Heather Maughan, Ivan Tattoli, Catherine J. Streutker, Jaye M. Platnich, Daniel A. Muruve, Dana J. Philpott, Stephen E. Girardin   +8 more
openaire   +3 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Wheat Disease Resistance Genes and Their Diversification Through Integrated Domain Fusions

Frontiers in Genetics, 2020
Plants are in a constant evolutionary arms race with their pathogens. At the molecular level, the plant nucleotide-binding leucine-rich repeat receptors (NLRs) family has coevolved with rapidly evolving pathogen effectors.
Ethan J. Andersen, Madhav P. Nepal, Jordan M. Purintun, Dillon Nelson, Glykeria Mermigka, Panagiotis F. Sarris, Panagiotis F. Sarris, Panagiotis F. Sarris   +7 more
doaj   +1 more source

The nucleotide binding domain of NRC-dependent disease resistance proteins is sufficient to activate downstream helper NLR oligomerization and immune signaling

bioRxiv, 2023
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins with pathogen sensor activities have evolved to initiate immune signaling by activating helper NLRs.
Mauricio P. Contreras, Pai Hsuan, Rebecca Thompson, Jules Claeys, Hiroaki Adachi, S. Kamoun   +5 more
semanticscholar   +1 more source

The Ups and Downs of Plant NLR Expression During Pathogen Infection

Frontiers in Plant Science, 2022
Plant Nucleotide binding-Leucine rich repeat (NLR) proteins play a significant role in pathogen detection and the activation of effector-triggered immunity.
Alicia Fick, Alicia Fick, Velushka Swart, Velushka Swart, Noëlani van den Berg, Noëlani van den Berg   +5 more
doaj   +1 more source

Maize ZmFNSI Homologs Interact with an NLR Protein to Modulate Hypersensitive Response [PDF]

International Journal of Molecular Sciences, 2020
Nucleotide binding, leucine-rich-repeat (NLR) proteins are the major class of resistance (R) proteins used by plants to defend against pathogen infection. The recognition between NLRs and their cognate pathogen effectors usually triggers a rapid localized cell death, termed the hypersensitive response (HR).
Yu-Xiu Zhu, Chunxia Ge, Shijun Ma, Xiao-Ying Liu, Mengjie Liu, Yang Sun, Guan-Feng Wang   +6 more
openaire   +2 more sources

Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.

PLoS Pathogens, 2013
Nucleotide-binding domain leucine-rich repeat (NLR) protein complexes sense infections and trigger robust immune responses in plants and humans. Activation of plant NLR resistance (R) proteins by pathogen effectors launches convergent immune responses ...
Xiquan Gao, Xin Chen, Wenwei Lin, Sixue Chen, Dongping Lu, Yajie Niu, Lei Li, Cheng Cheng, Matthew McCormack, Jen Sheen, Libo Shan, Ping He   +11 more
doaj   +1 more source