Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
core +2 more sources
Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. [PDF]
, 2014 Tumor invasion and metastases represent a complex series of molecular events that portends a poor prognosis. The contribution of inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) of innate immunity function as
Chin, Arnold I, Zhang, Hanwei
core +6 more sources
The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition [PDF]
Cell Reports, 2017 NLRP6 is a Nod-like receptor expressed in the intestinal epithelium. Previous studies reported a protective role for NLRP6 against intestinal injury and colitis-associated carcinogenesis via the regulation and establishment of a healthy microbiota. However, these results were not obtained using littermate animals, leaving the possibility that the pro ...
Paul Lemire +8 more
openaire +3 more sources
The Ups and Downs of Plant NLR Expression During Pathogen Infection
Frontiers in Plant Science, 2022 Plant Nucleotide binding-Leucine rich repeat (NLR) proteins play a significant role in pathogen detection and the activation of effector-triggered immunity.
Alicia Fick +5 more
doaj +1 more source
Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results. [PDF]
, 2018 Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements.
Canaud, Bernard +11 more
core +3 more sources
Estradiol and testosterone levels in patients undergoing partial hepatectomy - A possible signal for hepatic regeneration? [PDF]
, 1989 In five adult male patients undergoing a 40-60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively ...
A Francavilla +34 more
core +2 more sources
Frontiers in Plant Science, 2021 Plant intracellular immune receptor NLR (nucleotide-binding leucine-rich repeat) proteins sense the presence of pathogens and trigger strong and robust immune responses.
Leiyun Yang, Zhixue Wang, Jian Hua
doaj +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
An atypical NLR protein modulates the NRC immune receptor network [PDF]
, 2021 ABSTRACTThe NRC immune receptor network has evolved in asterid plants from a pair of linked genes into a genetically dispersed and phylogenetically structured network of sensor and helper NLR (nucleotide-binding domain and leucine-rich repeat-containing) proteins.
Hiroaki Adachi +6 more
openaire +1 more source
NLR network mediates immunity to diverse plant pathogens [PDF]
, 2017 Both plants and animals rely on nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins to respond to invading pathogens and activate immune responses. An emerging concept of NLR function is that “sensor” NLR proteins are paired with “
Ahmed Abd-El-Haliem +12 more
core +1 more source