Results 71 to 80 of about 122,087 (266)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

6 NLR Function in Fungi as Revealed by the Study of Self/Non-self Recognition Systems

, 2020
Plants and animals rely on cytoplasmic immune receptors of the NLR family to cope with a variety of biotic challenges. Proteins homologous to plant and animal NLRs were identified in fungi as part of the study of a non-self recognition and programmed ...
Sven J. Saupe, Dyrka, Witold, Asen Daskalov, Witold Dyrka, Daskalov, Asen, Saupe, Sven J.   +5 more
core   +1 more source

The rice blast resistance gene Ptr encodes an atypical protein required for broad-spectrum disease resistance

Nature Communications, 2018
Genes that confer resistance to plant pathogens such as rice blast disease typically encode NLR-type receptor proteins. Here, Zhao et al. describe a new resistance locus that encodes a non-NLR Armadillo repeat protein required for broad-spectrum ...
Haijun Zhao, Xueyan Wang, Yulin Jia, Bastian Minkenberg, Matthew Wheatley, Jiangbo Fan, Melissa H. Jia, Adam Famoso, Jeremy D. Edwards, Yeshi Wamishe, Barbara Valent, Guo-Liang Wang, Yinong Yang   +12 more
doaj   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Table1_Genome-wide identification and analysis of the NLR gene family in Medicago ruthenica.XLSX

, 2023
Medicago ruthenica, important forage in the legume family, possesses high nutritional value and carries abundant tolerance genes. This study used whole-genome data of M.
Yutong Zhang (4844703), Chunyan Tong (14367153), Fengling Shi (10025705)   +2 more
core   +1 more source

Comparative Genomics and Functional Studies of Wheat BED-NLR Loci

, 2020
Nucleotide-binding leucine-rich-repeat (LRR) receptors (NLRs) with non-canonical integrated domains (NLR-IDs) are widespread in plant genomes. Zinc-finger BED (named after the Drosophila proteins Boundary Element-Associated Factor and DNA Replication ...
Clemence Marchal, Cristobal Uauy, 10+ Wheat Genome Project 10+ Wheat Genome Project, Manuel Spannagl, Georg Haberer   +4 more
core   +2 more sources

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Proteins encoded by NLR genes present at the Yrr2 locus of B. distachyon accession BdTR13k compared with nearest equivalent Bd21 proteins.

, 2018
Proteins encoded by NLR genes present at the Yrr2 locus of B. distachyon accession BdTR13k compared with nearest equivalent Bd21 proteins.
Michael Ayliffe (5801552), Jan Bettgenhaeuser (799591), Robert F. Park (5801549), Davinder Singh (575400), Matthew J. Moscou (212174), Brian Gilbert (5801543), Narayana Upadhyaya (783631), Melanie Soliveres (5801546)   +7 more
core   +1 more source

Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles [PDF]

, 2017
To establish infection, pathogens deploy effectors to modify or remove host proteins. Plant immune receptors with nucleotide-binding, leucine-rich repeat domains (NLRs) detect these modifications and trigger immunity. Plant NLRs thus guard host "guardees.
Sømark, Kenneth, Roux, Milena Edna, Rodriguez Gomes, Eleazar José, Morten Petersen, Petersen, Klaus, Milena Roux, Bressendorff, Simon, Jensen, Michael Krogh, Signe Lolle, Michael Krogh Jensen, Kenneth Sømark, Greeff, Michael Christiaan, Roux, Milena, Petersen, Morten, Simon Bressendorff, Greeff, Christiaan, Rodriguez, Eleazar, Eleazar Rodriguez, Lolle, Signe, John Mundy, Christiaan Greeff, Klaus Petersen, Mundy, John   +22 more
core   +1 more source