Results 71 to 80 of about 8,284,629 (305)

The Nod-like receptor (NLR) family: a tale of similarities and differences. [PDF]

PLoS ONE, 2008
Innate immunity represents an important system with a variety of vital processes at the core of many diseases. In recent years, the central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses ...
Martina Proell, Stefan J Riedl, Jörg H Fritz, Ana M Rojas, Robert Schwarzenbacher   +4 more
doaj   +1 more source

Structure and Function of the TIR Domain from the Grape NLR Protein RPV1 [PDF]

Frontiers in Plant Science, 2016
The N-terminal Toll/interleukin-1 receptor/resistance protein (TIR) domain has been shown to be both necessary and sufficient for defense signaling in the model plants flax and Arabidopsis. In examples from these organisms, TIR domain self-association is required for signaling function, albeit through distinct interfaces.
Simon John Williams, Simon John Williams, Ling YIn, Ling YIn, Ling YIn, Gabriel Foley, Lachlan W Casey, Megan A Outram, Daniel J Ericsson, Jiang Lu, Jiang Lu, Mikael Boden, Ian Dry, Bostjan Kobe   +13 more
openaire   +6 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M. Guthridge, Carla Guthridge, Peter Izmirly, Jill P. Buyon, H. Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'Era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins*

Journal of Biological Chemistry, 2012
Background: Multiple functions have been ascribed to NLRC5 including MHC-I transcription and cytokine responses. Results: We generated Nlrc5−/− mice and showed that Nlrc5 increases classical and nonclassical MHC-I and causes removal of the gene-silencing
G. Robbins, A. Truax, B. Davis, Lu Zhang, W. Brickey, J. Ting   +5 more
semanticscholar   +1 more source

Simulation Framework Development for Helicopter Mission Analysis [PDF]

, 2010
Helicopter mission performance analysis has always been an important topic for the helicopter industry. This topic is now raising even more interest as aspects related to emissions and noise gain more importance for environmental and social impact ...
Mohseni, Martina, Pachidis, Vassilios, Vassilios Pachidis, Goulos, Ioannis, Stevens, J.M.G.F., Martina Mohseni, Roberto D’Ippolito, Ioannis Goulos, Jos Stevens, Mohseni, M., D’Ippolito, Roberto, Pachidis, V., Stevens, Jos, Goulos, I., d'Ippolito, R.   +14 more
core   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Dissection of Two Complex Clusters of Resistance Genes in Lettuce (Lactuca sativa)

Molecular Plant-Microbe Interactions, 2015
Of the over 50 phenotypic resistance genes mapped in lettuce, 25 colocalize to three major resistance clusters (MRC) on chromosomes 1, 2, and 4. Similarly, the majority of candidate resistance genes encoding nucleotide binding-leucine rich repeat (NLR ...
Marilena Christopoulou, Leah K. McHale, Alex Kozik, Sebastian Reyes-Chin Wo, Tadeusz Wroblewski, Richard W. Michelmore   +5 more
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source