Results 61 to 70 of about 8,284,629 (305)
EMBO Journal, 2022 Nucleotide‐binding domain leucine‐rich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity that can function as individual units or as pairs or networks.
Mauricio P. Contreras +12 more
semanticscholar +1 more source
PLoS Biology, 2021 Reference datasets are critical in computational biology. They help define canonical biological features and are essential for benchmarking studies. Here, we describe a comprehensive reference dataset of experimentally validated plant nucleotide-binding ...
Jiorgos Kourelis +3 more
semanticscholar +1 more source
Structural basis for specific flagellin recognition by the NLR protein NAIP5 [PDF]
Cell Research, 2017 The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive.
Yang, Xinru +10 more
openaire +4 more sources
Frontiers in Plant Science, 2021 Plant intracellular immune receptor NLR (nucleotide-binding leucine-rich repeat) proteins sense the presence of pathogens and trigger strong and robust immune responses.
Leiyun Yang, Zhixue Wang, Jian Hua
doaj +1 more source
Inhibition of the inflammasome response by a viral protein that interacts with NLRs
Communicative & Integrative Biology, 2011 Pattern recognition receptors (PRRs) constitute the first line of host defense against bacterial, fungal and viral pathogens. Upon sensing microbial infection, PRRs initiate a cascade of signal transduction and transcriptional events to induce the production of inflammatory cytokines.
Sean M, Gregory, Blossom, Damania
openaire +2 more sources
Conceptual design of Free Flight with airborne separation assurance [PDF]
, 1998 The study described in this paper originally only aimed at studying the human factors problems of airborne separation hi a Free Flight environment. However to define the Free Flight environment with sufficient detail, a concept was designed at NLR.
Gent, R.N.H.W. van +7 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
PlantsNucleotide-binding site-leucine-rich repeat (NLR) proteins are key intracellular immune receptors in plants. Integrated domains (IDs) can occasionally be fused with NLRs, contributing to their functional diversity. However, the diversity and evolutionary
Zhen Zeng +5 more
doaj +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source