Genome-wide identification and analysis of the NLR gene family in Medicago ruthenica
Frontiers in Genetics, 2023 Medicago ruthenica, important forage in the legume family, possesses high nutritional value and carries abundant tolerance genes. This study used whole-genome data of M.
Chunyan Tong +5 more
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The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling. [PDF]
J Biol Chem, 2018 Mammalian Nod-like receptor (NLR) proteins contribute to the regulation and induction of innate and adaptive immunity in mammals, although the function of about half of the currently identified NLR proteins remains poorly characterized.
Ellwanger K +7 more
europepmc +2 more sources
Dancing with the Stars: An Asterid NLR Family.
Trends in Plant Science, 2017 Wu and co-workers show how a network of sensor and helper NOD-like receptor proteins (NLRs) act together to confer robust resistance to diverse plant pathogens.
J. Rathjen, P. Dodds
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NLRC4 (NLR Family, CARD domain containing 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NLRC4 (NLR Family, CARD domain containing 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Y. Kumar, V. Radha, G. Swarup
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NLRC4/IPAF: a CARD carrying member of the NLR family. [PDF]
Clinical Immunology, 2009 The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria.
F. Sutterwala, R. Flavell
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Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member. [PDF]
Journal of Biotechnology, 2012 NOD1 (NLRC1) is a member of the NLR family of innate immunity proteins, which are important cellular sensors of various pathogens. Deregulated NOD1 signaling is involved in various autoimmune, inflammatory, and allergic diseases, making it a potential target for drug discovery.
Nadav Askari +3 more
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The Brassicaceae Family Displays Divergent, Shoot-Skewed NLR Resistance Gene Expression1[OPEN] [PDF]
Plant Physiology, 2017 Nucleotide-binding site leucine-rich repeat resistance genes (NLRs) allow plants to detect microbial effectors. We hypothesized that NLR expression patterns could reflect organ-specific differences in effector challenge and tested this by carrying out a meta-analysis of expression data for 1,235 NLRs from nine plant species.
D. Munch +6 more
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CATERPILLER (NLR) family members as positive and negative regulators of inflammatory responses. [PDF]
Proceedings of the American Thoracic Society, 2007 One of the most important advances in human immunology in the last decade has been the characterization of evolutionarily conserved molecular mediators important in controlling innate immunity. A prime example of this is the discovery of the mammalian Toll-like receptor family.
J. Lich, J. Ting
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Pan-NLR gene family analyses decipher evolutionary dynamics, population diversity, and potential disease resistance genes in cucumber [PDF]
BMC Plant BiologyBackground Cucumber (Cucumis sativus L.) is a globally important crop, yet its production is severely hampered by pathogen attacks, leading to substantial economic losses. Nucleotide-binding site-leucine-rich repeat (NLR) genes are critical components of
Baohui Zhang, Ying Deng
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NLR family member NLRC5 is a transcriptional regulator of MHC class I genes [PDF]
Proceedings of the National Academy of Sciences, 2010 MHC class I plays a critical role in the immune defense against viruses and tumors by presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key regulator of MHC class II gene expression that associates and cooperates with transcription factors in the MHC class II promoter. Although CIITA also transactivates MHC class
T. Meissner +8 more
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