Results 21 to 30 of about 87,795 (274)

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes [PDF]

Proceedings of the National Academy of Sciences, 2010
MHC class I plays a critical role in the immune defense against viruses and tumors by presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key regulator of MHC class II gene expression that associates and cooperates with transcription factors in the MHC class II promoter. Although CIITA also transactivates MHC class
Meissner, T.B., Li, A., Biswas, A., Lee, K.H., Liu, Y.J., Bayir, E., Iliopoulos, D., Elsen, P.J. van den, Kobayashi, K.S.   +8 more
openaire   +5 more sources

Diversity, abundance, and domain architecture of plant NLR proteins in Fabaceae

Heliyon
The resistance (R) gene family in plants is a vital component of the plant defense system, enabling host resistance against pathogens through interactions with pathogen effector proteins.
Vishal Singh Negi, Rajagopalbabu Srinivasan, Bhabesh Dutta   +2 more
doaj   +2 more sources

Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Few studies have investigated the mechanism by which exercise training promotes neural repair during rehabilitation after stroke. In this study, we evaluated the neuroprotective effects of exercise training and pyroptosis-associated factors
Fang Luo, Mingjin Zhu, Kunkun Lv, Di Sun, Guifen Yang, Guoyuan Pan   +5 more
doaj   +1 more source

Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis

Journal of Innate Immunity, 2023
PR domain-containing 1 with zinc finger domain (PRDM1) has been reported as a promoter of inflammation, which is a critical process involved in the pathogenesis of acute gouty arthritis.
Qingsong Zhao, Nan Xia, Jinmei Xu, Yingnan Wang, Luwen Feng, Dihan Su, Zhifeng Cheng   +6 more
doaj   +1 more source

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function [PDF]

Nature Communications
NLR family proteins act as intracellular receptors. Gene duplication amplifies the number of NLR genes, and subsequent mutations occasionally provide modifications to the second gene that benefits immunity.
Yuying Li, Qiong Wang, Huimin Jia, Kazuya Ishikawa, Ken-ichi Kosami, Takahiro Ueba, Atsumi Tsujimoto, Miki Yamanaka, Yasuyuki Yabumoto, Daisuke Miki, Eriko Sasaki, Yoichiro Fukao, Masayuki Fujiwara, Takako Kaneko-Kawano, Li Tan, Chojiro Kojima, Rod A. Wing, Alfino Sebastian, Hideki Nishimura, Fumi Fukada, Qingfeng Niu, Motoki Shimizu, Kentaro Yoshida, Ryohei Terauchi, Ko Shimamoto, Yoji Kawano   +25 more
doaj   +2 more sources

The NLR Gene Family: A Standard Nomenclature [PDF]

Immunity, 2008
Iimmune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, cryopyrin/NALP3 are members of a family characterized by the presence of a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). Members of this gene family encode a protein structure similar to the NB-LRR subgroup of disease-resistance genes in plants and are involved ...
Ting, Jenny P.-Y., Lovering, Ruth C., Alnemri, Emad S., Bertin, John, Boss, Jeremy M., Davis, Beckley K., Flavell, Richard A., Girardin, Stephen E., Godzik, Adam, Harton, Jonathan A., Hoffman, Hal M., Hugot, Jean-Pierre, Inohara, Naohiro, Mackenzie, Alex, Maltais, Lois J., Nunez, Gabriel, Ogura, Yasunori, Otten, Luc A., Philpott, Dana, Reed, John C., Reith, Walter, Schreiber, Stefan, Steimle, Viktor, Ward, Peter A.   +23 more
openaire   +3 more sources

An NLR family member X1 mutation (p.Arg707Cys) suppresses hepatitis B virus infection in hepatocytes and favors the interaction of retinoic acid-inducible gene 1 with mitochondrial antiviral signaling protein [PDF]

Archives of Virology
Qian Jiao, Shu Zhu, Baolin Liao
exaly   +2 more sources

New insights into the structure domain and function of NLR family CARD domain containing 5. [PDF]

Cell Commun Signal
NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central ...
Zhu H, Xiao C, Chen J, Guo B, Wang W, Tang Z, Cao Y, Zhan L, Zhang JH.   +8 more
europepmc   +2 more sources

Corrigendum: Genetic Variations of NLR family genes in Behcet's Disease. [PDF]

Sci Rep, 2016
Li L, Yu H, Jiang Y, Deng B, Bai L, Kijlstra A, Yang P.   +6 more
europepmc   +3 more sources

Regulation of intestinal microbiota by the NLR protein family [PDF]

International Immunology, 2013
Abstract The human intestine harbors a diverse microbial community consisting of a large number of bacteria and other micro-organisms that have co-evolved with the host intestinal immune system. During this process, microbiota and the host immune system shape one another by various mechanisms to achieve a successful symbiotic ...
Amlan, Biswas, Koichi S, Kobayashi
openaire   +2 more sources