Results 41 to 50 of about 90,508 (248)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

CATERPILLER (NLR) Family Members as Positive and Negative Regulators of Inflammatory Responses [PDF]

Proceedings of the American Thoracic Society, 2007
Abstract One of the most important advances in human immunology in the last decade has been the characterization of evolutionarily conserved molecular mediators important in controlling innate immunity. A prime example of this is the discovery of the mammalian Toll-like receptor family.
John D, Lich, Jenny P-Y, Ting
openaire   +2 more sources

Wheat Disease Resistance Genes and Their Diversification Through Integrated Domain Fusions

Frontiers in Genetics, 2020
Plants are in a constant evolutionary arms race with their pathogens. At the molecular level, the plant nucleotide-binding leucine-rich repeat receptors (NLRs) family has coevolved with rapidly evolving pathogen effectors.
Ethan J. Andersen, Madhav P. Nepal, Jordan M. Purintun, Dillon Nelson, Glykeria Mermigka, Panagiotis F. Sarris, Panagiotis F. Sarris, Panagiotis F. Sarris   +7 more
doaj   +1 more source

Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member [PDF]

Journal of Biotechnology, 2012
NOD1 (NLRC1) is a member of the NLR family of innate immunity proteins, which are important cellular sensors of various pathogens. Deregulated NOD1 signaling is involved in various autoimmune, inflammatory, and allergic diseases, making it a potential target for drug discovery.
Nadav, Askari, Ricardo G, Correa, Dayong, Zhai, John C, Reed   +3 more
openaire   +2 more sources

Neutrophil Lymphocyte Ratio (NLR) in COVID-19 Patients Receiving Convalescent Plasma Therapy

Indonesian Journal of Medical Laboratory Science and Technology, 2022
Recently, a new RNA virus from the Coronaviridae family was discovered, known as SARS-Cov-2. This virus causes pneumonia and inflammation in the body.
Desyani Ariza, Andi Maya Kesrianti, Tazya Anggraini Ruslan   +2 more
doaj   +1 more source

Modulation of Nod-like Receptor Expression in the Thymus during Early Pregnancy in Ewes

Vaccines, 2022
Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) are involved in modulating the innate immune responses of the trophoblast and the placenta in normal pregnancy.
Leying Zhang, Yuanjing Li, Zhenyang Zhao, Jiabao Cai, Shuxin Zhao, Ling Yang   +5 more
doaj   +1 more source

Genome-Wide Identification, Characterization, and Comparative Analysis of NLR Resistance Genes in Coffea spp.

Frontiers in Plant Science, 2022
The largest family of disease resistance genes in plants are nucleotide-binding site leucine-rich repeat genes (NLRs). The products of these genes are responsible for recognizing avirulence proteins (Avr) of phytopathogens and triggering specific defense
Mariana de Lima Santos, Mário Lúcio Vilela de Resende, Gabriel Sérgio Costa Alves, Jose Carlos Huguet-Tapia, Márcio Fernando Ribeiro de Júnior Resende, Jeremy Todd Brawner   +5 more
doaj   +1 more source

Jiedutongluotiaogan Formula Improves Pancreatic Dysfunction in db/db Mice through Modulating the Gut Microbiota-Short Chain Fatty Acids-NLR Family, Pyrin Domain–Containing Protein 3 Inflammasome

World Journal of Traditional Chinese Medicine
Objective: Disturbance of gut microbiota plays an essential role in metabolic diseases, such as diabetes. Jiedutongluotiaogan formula (JTTF) was designed to meliorate the symptoms of type 2 diabetes.
Jin-Li Luo, Wen-Qi Jin, Li Wang, Qi Zhang, Yu Wang, Cui Wu, Yue Qu, Yu-Ting Peng, Li-Wei Sun, Chun-Li Piao   +9 more
doaj   +1 more source

Genome-wide Comparative Analyses Reveal the Dynamic Evolution of Nucleotide-Binding Leucine-Rich Repeat Gene Family among Solanaceae Plants

Frontiers in Plant Science, 2016
Plants have evolved an elaborate innate immune system against invading pathogens. Within this system, intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors are known play critical roles in effector-triggered immunity (ETI) plant ...
Eunyoung Seo, Seungill Kim, Seon-In Yeom, Doil Choi   +3 more
doaj   +1 more source

All in the Family: The First Whole-Genome Survey of NLR Genes [PDF]

The Plant Cell, 2019
When The Plant Cell sent an invitation for me to write about an article that had a significant impact on my research, two articles came to mind immediately. One relates to our earlier work on flowering: the 2001 article by Lilac Pnueli and colleagues ([Pnueli et al., 2001][1]), which identified ...
openaire   +3 more sources