Results 111 to 120 of about 26,384,108 (210)

Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A [PDF]

, 2014
Background The BAG6 complex resides in the cytosol and acts as a sorting point to target diverse hydrophobic protein substrates along their appropriate paths, including proteasomal degradation and ER membrane insertion.
Ewelina M Krysztofinska, Krysztofinska, EM, Darby, John F., Arjun Thapaliya, Maria R. Conte (664444), Isaacson Rivka L., Alfano, C, Bishop, David S., Peter J. Simpson (247964), Santiago Martínez-Lumbreras (206438), Conte, Maria R., Martinez-Lumbreras, S, High, S, Newran Sriskandarajah (664440), Leznicki, P, Rivka L. Isaacson (393277), Aline C Simon, Leznicki Pawel, Conte, Maria R; id_orcid, Thapaliya, Arjun, Caterina Alfano, Conte Maria R., Hale, Lisa R, High, Stephen; id_orcid, Simpson, PJ, Caterina Alfano (664443), Hale, Lisa R., Hale Lisa R., Pawel Leznicki (393272), Krysztofinska, Ewelina M, Simon, Aline C, Martínez-Lumbreras, Santiago, Newran Sriskandarajah, Sriskandarajah Newran, Bishop David S., Isaacson, Rivka L, Sriskandarajah, N, Aline C. Simon (664439), Ewelina M. Krysztofinska (393276), Bishop, DS, Simpson Peter J., Maria R Conte, Simpson, Peter J, Leznicki, Pawel, Darby, JF, John F. Darby (664438), David S. Bishop (664441), Thapaliya, A, Alfano Caterina, Hale, LR, Stephen High (20210), Peter J Simpson, Thapaliya Arjun, Conte, Maria R, Stephen High, Isaacson, RL, Arjun Thapaliya (664445), Krysztofinska Ewelina M., Martínez-Lumbreras Santiago, High Stephen, Darby John F., Lisa R Hale, Isaacson, Rivka L; id_orcid, John F Darby, Rivka L Isaacson, Lisa R. Hale (664442), Isaacson, Rivka L., Conte, MR, Simon Aline C., Darby, John F, Pawel Leznicki, Simon, AC, Simon, Aline C., David S Bishop, Santiago Martínez-Lumbreras, Krysztofinska, Ewelina M., Sriskandarajah, Newran, Bishop, David S, High, Stephen, Simpson, Peter J., Alfano, Caterina   +80 more
core   +2 more sources

Medulloblastoma tumor suppressor factor RENKCTD11: structure and function based design and development of new compounds of theraupetical interest. [PDF]

, 2009
Hedgehog (Hh) signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors.
Pirone, Luciano
core   +1 more source

MicroRNA‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh   +11 more
wiley   +1 more source

Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish [PDF]

, 2011
Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Pontarotti, Pnontarotti, P., Lieke M van der Aa, van der Aa Lieke M., Benmansour, Abdenour, Abdenour Benmansour, Jouneau Luc, Benmansour, A., Pontarotti Pierre, Boudinot Pierre, Van Der Aa, Lieke M, Levraud, Jean-Pierre, Birolat, V., Levraud, L. P., Boudinot, Pierre, Du Pasquier Louis, Jouneau, Luc, Louis Du Pasquier, Benmansour Abdenour, Valérie Briolat, Jean-Pierre Levraud, Pasquier, L., du, Briolat Valérie, Aa, L.M., van der, Pontarotti, P., du Pasquier, L., Van der aa, Lieke, Jouneau, L., Levraud, J.P., Pontarotti, Pierre, van der Aa, L.M., Du Pasquier, Louis, Boudinot, P., Briolat, Valérie, Luc Jouneau, Lieke M. van der Aa, Levraud Jean-Pierre, Boudinot, R., Pierre Boudinot, van der Aa, L. M.   +39 more
core   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Effect of Heat Stress on the Expression of Circulating Cyto(chemo)kine and Inflammatory Markers in Broiler Chickens Selected for High- or Low-water Efficiency

Frontiers in Bioscience-Landmark
Background: Water scarcity is a current, significant global concern that will only increase under the pressure of climate change. Improving water efficiency of poultry is a new and promising area to help temper agriculture's future ...
Elizabeth S. Greene, Travis Tabler, Walter G. Bottje, Sara Orlowski, Sami Dridi   +4 more
doaj   +1 more source

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source

Cell Type‐Specific Roles of TBK1 in Steatotic Liver Disease: Evidence for an Inflammatory TBK1+CASP1+ Kupffer Cell State

Liver International, Volume 46, Issue 10, October 2026.
Yin Huang, Joanna Picó, Amalia Tzoumpa, Pedro Zapater, José M. González‐Navajas   +4 more
wiley   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source