Results 61 to 70 of about 18,494 (150)

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6.

PLoS ONE
BackgroundGestational diabetes mellitus is characterized by low-grade systemic inflammation. Placental inflammation in gestation diabetes mellitus has not been extensively investigated yet.ObjectivesAims of this study were to analyze: a) serum levels of ...
Marianna Onori, Giuliana Beneduce, Filomena Colella, Donatella Lucchetti, Caterina Policola, Vincenzo Arena, Fabio Sannino, Alessandro Petrecca, Dario Pitocco, Alfredo Pontecorvi, Alessandro Sgambato, Giovanni Scambia, Nicoletta Di Simone, Tullio Ghi, Chiara Tersigni   +14 more
doaj   +1 more source

Additional file 2 of Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes

Additional file 2. The sequences of siRNAs and the map of the pcDNA3.1 vector.
Chen, FengJuan, Xing, YuFeng, Chen, ZhiJie, Chen, XiaoMan, Li, Jie, Gong, Si, Luo, Fang, Cai, QingXian   +7 more
openaire   +1 more source

DHA Ameliorates Alzheimer’s Disease by Attenuating Microglial Pyroptosis via Regulation of the HOXA9-NLRP3 Pathway

Frontiers in Bioscience-Landmark
Background: Alzheimer’s disease (AD) involves a progressive deterioration of cognitive abilities, memory loss, and persistent brain inflammation.
Jia-Li Xie, Xiao-Hui Hu, Chun-Ling Wu, Qi Jin, Jian-Ping Pan   +4 more
doaj   +1 more source

Mechanical sensing migrasomes attenuated chronic infectious bone destruction via controlling mitochondria DNA dynamics

Nano Research
Mesenchymal stem cells (MSCs), which are mechanosensitive cells, mediate the cells crosstalk in response to mechanical force, thereby playing a crucial role in bone homeostasis.
Meilian Cai, Chenyang Xing, Peng Chen, Shuai Lin, Mingzhao Li, Han Zhang, Hu Zhao, Ruili Yang   +7 more
doaj   +1 more source

USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis

Frontiers in Immunology
Duodenogastric reflux (DGR) has been linked to the onset of gastric cancer (GC), although the precise mechanism is yet obscure. Herein, we aimed to investigate how refluxed bile acids (BAs) and macrophages are involved in gastric carcinogenesis.
Chenye Zhao, Mingchao Mu, Xiaopeng Li, Zepeng Dong, Jiahao Wang, Chengzhi Yao, Jianbao Zheng, Xuejun Sun, Junhui Yu   +8 more
doaj   +1 more source

Effect of Heat Stress on the Expression of Circulating Cyto(chemo)kine and Inflammatory Markers in Broiler Chickens Selected for High- or Low-water Efficiency

Frontiers in Bioscience-Landmark
Background: Water scarcity is a current, significant global concern that will only increase under the pressure of climate change. Improving water efficiency of poultry is a new and promising area to help temper agriculture's future ...
Elizabeth S. Greene, Travis Tabler, Walter G. Bottje, Sara Orlowski, Sami Dridi   +4 more
doaj   +1 more source

The role of inflammasome dysregulation in obstructive and non-obstructive azoospermia: a comparative molecular analysis of blood, tissue, and seminal plasma

Frontiers in Immunology
BackgroundTo address knowledge gaps, this study aimed to investigate the involvement of inflammasomes in the etiology of azoospermia. This study focused on the gene expression of key inflammasome components, including NLR family pyrin domain containing 3
Seyyed AmirHossein Mirghanizadeh Bafghi, Farzaneh Fesahat, Fateme Zare, Maryam Imani, Serajoddin Vahidi, Hossein Ansariniya, Hossein Ansariniya, Ali ZareHoroki, Hossein Hadinedoushan   +8 more
doaj   +1 more source

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

Frontiers in Cell and Developmental Biology
High mobility group box-1 (HMGB1) is a protein released from stressed or damaged cells that triggers immune activation and chronic inflammation.
Lei Yang, Xue Li, Xiaoming Zhu, Futao Ge, Yuantao Wang   +4 more
doaj   +1 more source

Biological Therapies for Urate Lowering and Inflammation Control in Gout Management

Journal of Inflammation Research
Ye Zhou,1,* Hengyan Zhang,2,* Nian Liu,1,3,* Heguo Yan,1 Fanyu Meng,1 Jiangyun Peng1,3 1First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, People’s Republic of China; 2Department of Rheumatology ...
Zhou Y, Zhang H, Liu N, Yan H, Meng F, Peng J   +5 more
doaj  

RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells

Scientific Reports
Gastric cancer (GC) is one of the most common malignancies worldwide, and its development is closely associated with the abnormal expression of numerous genes. RNA - binding protein with multiple splicing 2 (RBPMS2), a member of the RNA - binding protein
Nailin Zhang, Lina Yan, Hua Cao, Nana Zhang, Tong Zhang, Shengjiang Guan, Qiquan Liu   +6 more
doaj   +1 more source